公开(公告)号：US20170240973A1

公开(公告)日：2017-08-24

申请号：US15442993

申请日：2017-02-27

Applicant: Guardant Health, Inc.

Inventor： Helmy ELTOUKHY ,  AmirAli TALASAZ ,  Darya CHUDOVA ,  Diana ABDUEVA

IPC: C12Q1/68 ,  G06F19/22

CPC classification number: C12Q1/6886 ,  C12Q1/6809 ,  C12Q1/6874 ,  G16B30/00 ,  G16B99/00 ,  C12Q2535/122 ,  C12Q2537/165

Abstract: Methods are provided herein to improve automatic detection of copy number variation in nucleic acid samples. These methods provide improved approaches for determining baseline copy number of genetic loci within a sample, reduce variation due to features of genetic loci, sample preparation, and probe exhaustion.