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公开(公告)号：US20120145394A1
公开(公告)日：2012-06-14
申请号：US13316239
申请日：2011-12-09
申请人： Michael Jensen , Ruben Martinez
发明人： Michael Jensen , Ruben Martinez
摘要： A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated. This is particularly advantageous where cutting is to be applied to downhole metal based obstructions.
摘要翻译： 一种可旋转的井下切割工具，其配置为在低功率环境下提高驱动一致性。 该工具配备有适用于有线部署的液压轴向驱动执行器。 致动器本身包括具有滚珠丝杠的往复式活塞，该滚珠丝杠与滚珠螺母螺纹接合，以阻尼由活塞施加的轴向驱动。 因此，即使液压驱动通常在大约10马力以下，基本上消除了轴向驱动中的反弹。 这对于应用于井下金属的障碍物的切割是特别有利的。
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公开(公告)号：US20120061096A1
公开(公告)日：2012-03-15
申请号：US13129939
申请日：2009-11-18
IPC分类号： E21B29/00
CPC分类号： E21B29/02
摘要： The present invention provides a practical method capable of substantially removing downhole equipment by dissolving it with a chemical. The method comprises introducing an equipment dissolution mixture comprising one or more chemicals and/or materials suitable for the substantial dissolution of the downhole equipment.
摘要翻译： 本发明提供了一种实用的方法，其能够通过用化学品溶解来基本上去除井下设备。 该方法包括引入包含一种或多种适用于井下设备基本溶解的化学物和/或材料的设备溶解混合物。
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公开(公告)号：US20110223129A1
公开(公告)日：2011-09-15
申请号：US13046518
申请日：2011-03-11
申请人： Michael Jensen
发明人： Michael Jensen
CPC分类号： A61K38/2086 , A61K35/17 , A61K38/1774 , C07H21/04 , C07K14/5437 , C07K14/7051 , C07K14/70514 , C07K14/7155 , C07K16/46 , C07K19/00 , C07K2319/00 , C07K2319/30 , C12N5/0636 , C12N15/63
摘要： The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targeting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.
摘要翻译： 本发明涉及由跨膜结构域组成的嵌合跨膜免疫受体，其包含与能够将细胞外结构域连接至细胞表面的支持区连接的可溶性受体配体，跨膜区和细胞内信号结构域。 当在T淋巴细胞表面上表达时，Zetakines将T细胞活性直接导向表达可溶性受体配体特异性受体的那些特异性细胞。 替扎林嵌合免疫受体代表了用于重定向T细胞的抗原特异性的抗体型免疫受体的新型延伸，应用于各种癌症的治疗，特别是通过人类恶性利用的自身免疫/旁分泌细胞因子系统。 在一个优选的实施方案中是包含与IgG的Fc区连接的IL-13Rα2特异性IL-13突变体IL-13（E13Y）的细胞外靶向结构域的人胶质瘤特异性免疫受体，人CD4的跨膜结构域和人 CD3ζ链。
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94.发明授权Seasoning and method for seasoning a food product while reducing dietary sodium intake 有权调味食品的调味方法，同时减少饮食中的钠摄入量公开(公告)号：US07923047B2
公开(公告)日：2011-04-12
申请号：US11708667
申请日：2007-02-20
IPC分类号： A23L1/22
CPC分类号： A23L13/428 , A23L7/174 , A23L27/40 , A23L27/86 , A23V2002/00 , A23V2200/254 , A23V2250/1614
摘要： A seasoning for reducing dietary sodium intake is disclosed. The portion of seasoning has a mean particle size of less than or equal to 20 microns. In one embodiment, the invention is a seasoning comprising a first seasoning component including a salt and a second seasoning component selected for at least one of complementing and reducing the amount of the first seasoning component required for flavoring a food product.
摘要翻译： 披露了减少膳食钠摄入的调味料。 调料的部分平均粒度小于或等于20微米。 在一个实施方案中，本发明是一种调味料，其包括第一调味成分，其包含盐和第二调味成分，所述第二调味成分选自补充和减少调味食品所需的第一调味成分的量中的至少一种。
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公开(公告)号：US20090257994A1
公开(公告)日：2009-10-15
申请号：US12314195
申请日：2008-12-05
申请人： Michael Jensen
发明人： Michael Jensen
CPC分类号： A61K38/2086 , A61K35/17 , A61K38/1774 , C07H21/04 , C07K14/5437 , C07K14/7051 , C07K14/70514 , C07K14/7155 , C07K16/46 , C07K19/00 , C07K2319/00 , C07K2319/30 , C12N5/0636 , C12N15/63
摘要： The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human malignancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targetting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.
摘要翻译： 本发明涉及由跨膜结构域组成的嵌合跨膜免疫受体，其包含与能够将细胞外结构域连接至细胞表面的支持区连接的可溶性受体配体，跨膜区和细胞内信号结构域。 当在T淋巴细胞表面上表达时，Zetakines将T细胞活性直接导向表达可溶性受体配体特异性受体的那些特异性细胞。 Zetakine嵌合免疫受体代表了用于重定向T细胞的抗原特异性的基于抗体的免疫受体的新的延伸，其应用于治疗多种癌症，特别是通过人类恶性肿瘤使用的自身免疫/旁分泌细胞因子系统。 在一个优选的实施方案中是包含与IgG的Fc区连接的IL-13Ralpha2特异性IL-13突变体IL-13（E13Y）的细胞外靶向结构域的人胶质瘤特异性免疫受体，人CD4的跨膜结构域和人 CD3ζ链。
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96.发明申请公开(公告)号：US20090048436A1
公开(公告)日：2009-02-19
申请号：US11893614
申请日：2007-08-15
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The present invention provides a method of synthesizing phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linker has the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleaves to produce 5′ and 3′ ends that are fully biologically compatible, (iii) cleaves completely under conditions that are already used in cleavage/deprotection processes so it is fully compatible with conditions that are common in laboratories and does not require additives that necessitate further purification after cleavage, (iv) integrates easily onto commercially available synthesizers because it is compatible with standard coupling chemistry, and (v) is compatible with DNA, RNA, forward, reverse, and LNA, synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art.
摘要翻译： 本发明提供了一种合成亚磷酰胺接头的方法，其可用于串联合成两种或多种寡核苷酸。 本发明的接头具有以下所需的性质：（i）与先前公开的接头相比，提高了对碱性条件的稳定性，（ii）切割产生完全生物相容的5'和3'末端，（iii）在条件下完全切割 已经用于裂解/去保护过程，因此它与实验室常见的条件完全相容，并且不需要在裂解后需要进一步纯化的添加剂，（iv）容易地与市售合成仪整合，因为它与标准偶联化学相容，并且 （v）与DNA，RNA，正向，反向和LNA的合成化学物质相容。 此外，本发明的接头可以连接到固体支持物。 因此，本发明的接头提供了现有技术的显着进步。
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公开(公告)号：US07427930B2
公开(公告)日：2008-09-23
申请号：US10744686
申请日：2003-12-23
申请人： David V. Arnold , Logan Harris , Michael Jensen , Thomas William Karlinsey , Ryan Smith , Jonathan L. Waite , John B. Dougall, Jr.
发明人： David V. Arnold , Logan Harris , Michael Jensen , Thomas William Karlinsey , Ryan Smith , Jonathan L. Waite , John B. Dougall, Jr.
CPC分类号： H01Q21/0006 , G01S7/032 , G01S7/352 , G01S13/04 , G01S13/34 , G08G1/042 , H01Q13/106 , H01Q21/08
摘要： A vehicle traffic sensor for detecting and monitoring vehicular targets is presented. The sensor employs a planar design resulting in a reduced profile sensor. The sensor includes a multi-layer radio frequency board with RF components on one of the sides and both isolation and planar array antennas on the opposing side. The antennas are preferably tapered planar array antennas which include one transmit antenna and one receive antenna. The sensor also includes at least one logic or signal processing board populated with components on a first side and a ground plane on a second side positioned toward the RF componentry of the RF board to form an RF shield. The boards are housed within a housing that is permeable, at least on the side through which the antenna structures propagate.
摘要翻译： 提出了一种用于检测和监控车辆目标的车辆交通传感器。 该传感器采用平面设计，从而减少轮廓传感器。 该传感器包括在其一侧具有RF部件的多层射频板以及相对侧的隔离和平面阵列天线。 天线优选是包括一个发射天线和一个接收天线的锥形平面阵列天线。 该传感器还包括至少一个逻辑或信号处理板，其填充有第一侧上的部件和位于RF板的RF部件的第二侧上的接地平面，以形成RF屏蔽。 板被容纳在可透气的壳体内，至少在天线结构传播的一侧。
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98.发明申请Methods and compositions for modification of the human glucocorticoid receptor locus 有权用于修饰人类糖皮质激素受体位点的方法和组合物公开(公告)号：US20080188000A1
公开(公告)日：2008-08-07
申请号：US11983888
申请日：2007-11-13
CPC分类号： C12N15/86 , C07K14/721 , C12N9/22 , C12N15/62 , C12N2710/10043 , C12N2740/15043 , G01N33/743 , G01N2333/723
摘要： Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
摘要翻译： 本文公开了通过靶向切割编码GR的基因组DNA来灭活人类糖皮质激素受体（GR）基因的方法和组合物。 这些方法和组合物可用于例如在糖皮质激素治疗期间需要保留免疫功能的治疗应用中。
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99.发明申请公开(公告)号：US20080075813A1
公开(公告)日：2008-03-27
申请号：US11904554
申请日：2007-09-27
申请人： Gordon Smith , Michael Jensen
发明人： Gordon Smith , Michael Jensen
摘要： An encapsulated seasoning and method for seasoning for preserving, seasoning, enhancing, and potentiating flavor in a variety of foods and beverages is disclosed. The encapsulated seasoning may include shell and a core, the core comprising at least one seasoning particle having a particle size less than 25 microns and a non-aqueous composition. The encapsulated seasoning particle may include sodium chloride, as a seasoning, and a hydrophobic shell. Encapsulated small sodium chloride may be more effective in delivering taste impact than larger sized sodium chloride. Therefore, less sodium chloride may be required for the same taste effect resulting in less dietary sodium intake.
摘要翻译： 公开了一种用于调味，调味，增强和增强各种食品和饮料中的风味的调味料的封装调味料和方法。 包封的调味料可以包括壳和芯，芯包含至少一种粒度小于25微米的调味颗粒和非水组合物。 包封的调味颗粒可以包括氯化钠，调味料和疏水壳。 与较大尺寸的氯化钠相比，包封的小氯化钠可能更有效地提供味觉冲击。 因此，对于相同的味道效果可能需要较少的氯化钠，导致较少的膳食钠摄入量。
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公开(公告)号：US20070234020A1
公开(公告)日：2007-10-04
申请号：US11567290
申请日：2006-12-06
申请人： Michael Jensen
发明人： Michael Jensen
IPC分类号： G06F9/48
CPC分类号： G06F9/462 , G06F9/30018 , G06F9/3004 , G06F9/30101 , G06F9/30185 , G06F9/4812
摘要： An instruction encoding architecture is provided for a microprocessor to allow atomic modification of privileged architecture registers. The instructions include an opcode that designates to the microprocessor that the instructions are to execute in privileged (kernel) state only, and that the instructions are to communicate with privileged control registers, a field for designating which of a plurality of privileged architecture registers is to be modified, a field for designating which bit fields within the designated privileged architecture register is to be modified, and a field to designate whether the whether the designated bit fields are to be set or cleared. The instruction encoding allows a single instruction to atomically set or clear bit fields within privileged architecture registers, without reading the privileged architecture registers into a general purpose register. In addition, the instruction encoding allows a programmer to specify whether the previous content of a privileged architecture register is to be saved to a general purpose register during the atomic modification.
摘要翻译： 为微处理器提供指令编码架构，以允许对特权架构寄存器进行原子修改。 指令包括指定给微处理器的操作码，指令仅在特权（内核）状态下执行，并且指令将与特权控制寄存器进行通信，该字段用于指定多个特权体系结构寄存器中的哪一个到 被修改，用于指定要修改指定的特权体系结构寄存器中的哪些位字段的字段以及用于指定是否要设置或清除指定位字段的字段。 指令编码允许单个指令在特权体系结构寄存器中原子地设置或清除位字段，而不将特权体系结构寄存器读入通用寄存器。 此外，指令编码允许程序员指定在原子修改期间是否将特权架构寄存器的先前内容保存到通用寄存器。
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