Pharmaceutical compositions containing fatty acid amide derivatives
    92.
    发明授权
    Pharmaceutical compositions containing fatty acid amide derivatives 失效
    含有脂肪酸酰胺衍生物的药物组合物

    公开(公告)号:US3995059A

    公开(公告)日:1976-11-30

    申请号:US174149

    申请日:1971-08-23

    摘要: A pharmaceutical composition consisting essentially of pharmaceutically effective amount of an N-substituted fatty acid amide of the formula, ##EQU1## wherein R is a C.sub.13 - C.sub.25 aliphatic hydrocarbon chain or a C.sub.13 - C.sub.25 hydroxylated aliphatic hydrocarbon chain and RCO-- is other than isostearoyl; R' is d- or l-.alpha.-C.sub.1 - C.sub.4 alkylbenzyl, racemic-, d- or l-.alpha.-C.sub.1 - C.sub.4 alkylbenzyl substituted in the benzene ring with one or two substituents selected from the group consisting of C.sub.1 - C.sub.4 alkyl, C.sub.1 - C.sub.4 alkoxy, halogen and nitro, or racemic-, d- or l-.alpha.-benzylbenzyl; R" is hydrogen; or R' and R" together are cyclohexyl; and when RCO-- is isotearoyl R' is alkyl, alkenyl, cycloalkyl, alkylcycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, alkylphenyl, hydroxyphenyl, alkoxyphenyl, halogenophenyl, halogen-alkyl-substituted phenyl, halogenoalkyl- and halogen-substituted phenyl, alkoxy- and halogen-substituted phenyl, benzyl, racemic-, d- or l-.alpha.-C.sub.1 - C.sub.4 alkylbenzyl, benzyl substituted in the benzene ring with lower alkyl or lower alkoxy, racemic-, d- or l-.alpha.-benzylbenzyl or hydroxybenzyl, and R" is hydrogen or any one of the groups represented by R', and a pharmaceutically acceptable carrier, which is useful for lowering elevated levels of cholesterol in the blood.

    摘要翻译: 基本上由药学有效量的式R'R-CO-N ANGLE R“的N-取代脂肪酸酰胺组成的药物组合物,其中R是C 13 -C 25脂族烃链或C 13 -C 25羟基化脂族烃 链和RCO-不是异硬脂酰基; R'是在苯环中被一个或两个选自C 1 -C 4烷基,C 1 -C 4烷基,C 1 -C 4烷基,C 1 -C 4烷基, C 1 -C 4烷氧基,卤素和硝基,或外消旋 - ,d-或1-α-苄基苄基; R“是氢; 或R'和R“一起为环己基; 当RCO-为异月桂酰基R'为烷基,烯基,环烷基,烷基环烷基,羟基环烷基,烷氧基环烷基,烷基苯基,羟基苯基,烷氧基苯基,卤代苯基,卤代 - 烷基取代的苯基,卤代烷基 - 和卤素取代的苯基,烷氧基 - 和卤素取代 苯基,苄基,外消旋 - ,d-或1-α-C 1 -C 4烷基苄基,在苯环中被低级烷基或低级烷氧基取代的苄基,外消旋 - ,d-或1-α-苄基苄基或羟基苄基,R“ 是氢或由R'表示的基团中的任何一个,以及可用于降低血液中胆固醇升高的药学上可接受的载体。