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115 条记录 (耗时 0.047 秒)

    Processes for producing coenzyme Q10
    91.
    发明授权
    Processes for producing coenzyme Q10 有权
    生产辅酶Q10的方法

    公开(公告)号：US07910340B2

    公开(公告)日：2011-03-22

    申请号：US11981181

    申请日：2007-10-31

    申请人： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C12P1/00 ,  C12P7/66

    CPC分类号： C12P7/66 ,  C12P7/22

    摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.

    摘要翻译： 本发明涉及还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有不少于70摩尔％的还原型辅酶Q10的微生物细胞，任选地破坏细胞并回收如此生产的还原型辅酶Q10。 本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至 此后氧化由此得到的还原型辅酶Q10。 根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

    Process for production of optically active 2-halogeno-carboxylic acids
    94.
    发明授权
    Process for production of optically active 2-halogeno-carboxylic acids 失效
    光学活性2-卤代羧酸的制备方法

    公开(公告)号：US07473803B2

    公开(公告)日：2009-01-06

    申请号：US10503264

    申请日：2003-02-04

    申请人： Koki Yamashita ,  Toshihiro Takeda ,  Yasuyoshi Ueda

    发明人： Koki Yamashita ,  Toshihiro Takeda ,  Yasuyoshi Ueda

    IPC分类号： C07C53/19 ,  C07B39/00

    CPC分类号： C07C51/412 ,  C07C51/363 ,  C07C51/43 ,  C07C53/19

    摘要： The invention provides processes for producing efficiently optically active 2-halogenocarboxylic acids useful in the preparation of drugs or the like and salts thereof with amines. Specifically, an optically active 2-halogenocarboxylic acid is produced by halogenating an optically active amino acid in water in the presence of a hydrophobic organic solvent and nitrous acid with the configuration retained and with the racemization inhibited through the removal of 2-hydroxy-bromocarboxylic acid formed as a by-product; the obtained optically active 2-halogenocarboxylic acid is transferred to an aqueous phase by converting it into a salt thereof with a base, followed by the removal of the organic phase; and the optically active 2-halogenocarboxylic acid is transferred again to an organic solvent phase, followed by the removal of the aqueous phase, whereby an optically active 2-halogenocarboxylic acid is obtained through the removal of a halogen component. Further, a high-quality salt of an optically active 2-halogenocarboxylic acid with an amine can be obtained by a crystallization method wherein the amine is added over the period of ½ hour or longer either continuously or in portions and/or wherein the crystallization solvent consists of a hydrophobic organic solvent and a hydrophilic organic solvent.

    摘要翻译： 本发明提供了可用于制备药物等的有效光学活性2-卤代羧酸的方法及其与胺的盐。 具体地说，光学活性2-卤代羧酸是通过在疏水性有机溶剂和亚硝酸的存在下在水中卤化光学活性氨基酸而形成的，其中保留了结构，并且通过除去2-羟基 - 溴羧酸，外消旋化被抑制 形成副产品; 将得到的光学活性2-卤代羧酸通过将其转化为其盐与碱反应，然后除去有机相，转移到水相中。 并将光学活性2-卤代羧酸再次转移到有机溶剂相中，然后除去水相，由此通过除去卤素组分获得光学活性的2-卤代羧酸。 此外，光学活性2-卤代羧酸与胺的高品质盐可以通过结晶方法获得，其中胺在连续或部分加入0.5小时或更久的时间内和/或其中结晶溶剂 由疏水性有机溶剂和亲水性有机溶剂构成。

    Method for obtaining optically active epoxide
    95.
    发明授权
    Method for obtaining optically active epoxide 失效
    获得光学活性环氧化物的方法

    公开(公告)号：US07230126B2

    公开(公告)日：2007-06-12

    申请号：US10475122

    申请日：2002-05-10

    申请人： Tadashi Moroshima ,  Yasuyoshi Ueda

    发明人： Tadashi Moroshima ,  Yasuyoshi Ueda

    IPC分类号： C07D301/02

    CPC分类号： C07D301/36 ,  C07D301/32 ,  C07D303/08

    摘要： The present invention provides a method capable of suppressing a decrease in optical purity due to the exposure to heat during distillation of an optically active epoxide to permit an optically active epoxide of high quality to be simply obtained on an industrial scale. In the method, an optically active epoxide is distilled in the presence of a base to suppress a decrease in optical purity.

    摘要翻译： 本发明提供了一种能够抑制光学活性环氧化物蒸馏期间暴露于热量时光学纯度降低的方法，以便以工业规模简单地获得高质量的光学活性环氧化物。 在该方法中，在碱的存在下蒸发光学活性环氧化物以抑制光学纯度的降低。

    Method of stabilizing reduced coenzyme Q10 and method of acidic crystallization
    97.
    发明授权
    Method of stabilizing reduced coenzyme Q10 and method of acidic crystallization 有权
    稳定还原型辅酶Q10的方法和酸性结晶方法

    公开(公告)号：US07169590B2

    公开(公告)日：2007-01-30

    申请号：US10484227

    申请日：2002-07-15

    申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C12N9/96

    CPC分类号： C07C41/40 ,  C07C41/46 ,  C07C43/23

    摘要： The present invention relates to a method of efficiently producing reduced coenzyme Q10 having excellent qualities which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. This method is suitable for industrial production thereof.It is possible to handle reduced coenzyme Q10 in state of being protected from oxidation by molecular oxygen by bringing the reduced coenzyme Q10 in contact with a solvent containing a strong acid. Furthermore, when reduced coenzyme Q10 is crystallized in the presence of a strong acid, crystallization can be carried out while the formation of oxidized coenzyme Q10 as a by product is minimized, and, then high-quality crystals thereof can be produced.

    摘要翻译： 本发明涉及一种有效生产具有优良品质的还原型辅酶Q 10的方法，其可用作食品，功能性营养食品，特定保健食品，营养补充剂，营养物，动物药物，饮料中的成分 ，饲料，化妆品，药​​品，补救措施，预防药品等。该方法适用于工业生产。 可以通过使还原型辅酶Q 10与含有强酸的溶剂接触来处理被分子氧氧化的状态下的还原型辅酶Q 10。 此外，当还原型辅酶Q 10在强酸存在下结晶时，可以进行结晶，同时作为副产物形成氧化型辅酶Q 10被最小化 ，然后可以制造其高质量的晶体。

    Optically active 3,3'-dithiobis(2-amino-2methylpropionic acid) derivative and process for producing optically active 2-amino-3-mercapto-2-methylpropionic acid derivative
    98.
    发明申请
    Optically active 3,3'-dithiobis(2-amino-2methylpropionic acid) derivative and process for producing optically active 2-amino-3-mercapto-2-methylpropionic acid derivative 审中-公开
    光活性的3,3'-二硫代双（2-氨基-2-甲基丙酸）衍生物和光学活性2-氨基-3-巯基-2-甲基丙酸衍生物的制备方法

    公开(公告)号：US20070010689A1

    公开(公告)日：2007-01-11

    申请号：US10570791

    申请日：2004-08-18

    申请人： Shingo Matsumoto ,  Hiroshi Murao ,  Takao Yamaguchi ,  Masashi Izumida ,  Yasuyoshi Ueda

    发明人： Shingo Matsumoto ,  Hiroshi Murao ,  Takao Yamaguchi ,  Masashi Izumida ,  Yasuyoshi Ueda

    IPC分类号： C07C323/50

    CPC分类号： C07D403/12 ,  C07B2200/07 ,  C07C319/06 ,  C07C323/58 ,  C07D233/76 ,  C12P7/52 ,  C12P11/00 ,  C12P41/002

    摘要： The present invention provides a useful novel intermediate and a novel synthetic process that can highly prevent contamination by various impurities to an optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof useful as an intermediate for pharmaceuticals and the like and provides a process for easily and efficiently producing a high purity optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof on an industrial production scale. A process of producing a high purity 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof includes reductively cleaving a sulfur-sulfur bond of an intermediate, which is a high purity optically active 3,3′-dithiobis(2-amino-2-methylpropionic acid) derivative substantially free of impurities. Thus, a resulting optically active 2-amino-3-mercapto-2-methylpropionic acid derivative can be produced without generating impurities as by-products which are difficult to remove.

    摘要翻译： 本发明提供了一种有用的新型中间体和新型合成方法，其可以高度防止各种杂质污染2-氨基-3-巯基-2-甲基丙酸衍生物的光学活性R或S异构体或其盐，其用作 药物等的中间体，并且以工业生产规模提供容易且有效地制备2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的高纯度光学活性R或S异构体的方法。 制备高纯度2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的方法包括还原性地裂解作为高纯度光学活性3,3'-二硫代双（2）的中间体的硫 - 硫键 - 氨基-2-甲基丙酸）衍生物。 因此，得到的光学活性2-氨基-3-巯基-2-甲基丙酸衍生物可以不产生作为难以除去的副产物的杂质。

    Process for the production of optically active compounds having substituents at the 2-position
    99.
    发明申请
    Process for the production of optically active compounds having substituents at the 2-position 审中-公开
    用于制备在2-位具有取代基的光学活性化合物的方法

    公开(公告)号：US20060247458A1

    公开(公告)日：2006-11-02

    申请号：US10546823

    申请日：2004-02-25

    申请人： Shogo Yamamoto ,  Toshihiro Takeda ,  Yoshihide Fuse ,  Yasuyoshi Ueda

    发明人： Shogo Yamamoto ,  Toshihiro Takeda ,  Yoshihide Fuse ,  Yasuyoshi Ueda

    IPC分类号： C07C319/02

    CPC分类号： C07B53/00 ,  C07B2200/07 ,  C07C51/363 ,  C07C319/14 ,  C07C57/58 ,  C07C323/56

    摘要： The present invention provides a process for producing an optically active compound having a thio group at the 2-position important for manufacturing medicines. An optically active compound having a hydroxyl group at the 2-position is chlorinated with inversion of the configuration at the 2-position, and the resultant optically active compound having a chlorine atom at the 2-position is reacted with a metal thiolate to introduce a thio group with inversion of the configuration at the 2-position. This process is capable of minimizing racemization and producing an optically active compound having a thio group at the 2-position at low cost in high yield. When the optically active compound having a chlorine atom at the 2-position is reacted with the metal thiolate in coexistence with water in the reaction system, the optically active compound having a thio group at the 2-position with higher optical purity can be produced in higher yield. An optically active carboxylic acid having a thio group at the 2-position is crystallized in the presence of an aliphatic hydrocarbon solvent and/or a sulfur-containing solvent to effectively remove coexistent impurities such as an optical isomer and the like, thereby producing crystals of an optically active carboxylic acid having a thio group at the 2-position with higher purity.

    摘要翻译： 本发明提供了制造药物重要的2位具有硫基的光学活性化合物的方法。 在2-位上具有羟基的光学活性化合物用2-位反转形式进行氯化，所得2-位上具有氯原子的光学活性化合物与金属硫醇盐反应，引入 硫基与2-位配位反转。 该方法能够使外消旋化最小化，并以高产率以低成本制备在2-位具有硫基的光学活性化合物。 当反应体系中2-位上具有氯原子的光学活性化合物与金属硫醇盐在水中共存时，具有较高光学纯度的2位具有硫基的光学活性化合物可以在 更高的产量。 在脂肪族烃溶剂和/或含硫溶剂的存在下，在2-位具有硫基的光学活性羧酸结晶化，以有效除去共同的杂质如旋光异构体等，从而产生 在2-位具有较高纯度的具有硫基的光学活性羧酸。