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    Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl)ethoxycarbon1]-5-oxazolidine carboxylic acids
    91.
    发明申请
    Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl)ethoxycarbon1]-5-oxazolidine carboxylic acids 失效
    使用3 - [（取代-2-三烷基甲硅烷基）乙氧基羰基] -5-恶唑烷羧酸制备抗癌紫杉烷的方法

    公开(公告)号：US20080064887A1

    公开(公告)日：2008-03-13

    申请号：US11812180

    申请日：2007-06-15

    申请人： Arun Sharma ,  Subrata Sarkar ,  Jyan Mahanty

    发明人： Arun Sharma ,  Subrata Sarkar ,  Jyan Mahanty

    IPC分类号： C07D305/04

    CPC分类号： C07D263/04 ,  C07D305/14 ,  C07D413/12

    摘要： This invention relates to a process for preparation of taxanes comprising subjecting 7,10-diprotected intermediates 7-O-(2-haloacyl)baccatin III 6c or 7,10-O-di-(2-haloacyl)-10-deacetylbaccatin III 6b to a step of coupling with (4S,5R)-3-[(2-alkyl/aryl-2-trialkylsilyl)ethoxy-carbonyl]-4-aryl-2-substituted-1,3-oxazolidine-5-carboxylic acid 1 in the presence of a condensation agent, an activating agent and an aromatic hydrocarbon to obtain 7-O-[2-(haloacyl)]-13-[(4S,5R)-4-aryl-2-substituted-3(2-unsubstituted/substituted-2-trialkylsilyl)-ethoxycarbonyl-1,3-oxazolidinyl-5-carbonyl]baccatin III 7a or 7,10-di-O [2-(haloacyl)]-13-[(4S,5R)-4-aryl-2-substituted-3-(2-unsubstituted/substituted-2-trialkylsilyl)ethoxy-carbonyl-1, 3-oxazolidinyl-5-carbonyl]-10-deacetylbaccatin III 7b; treating the coupled products 7-O-[2-(haloacyl)]-13-[(4S,5R)-4-aryl-2-substituted-3-(2-substituted-2-trialkylsilyl)ethoxy-carbonyl-1, 3-oxazolidinyl-5-carbonyl]baccatin III 7a or 7,10-di-O-[2[(haloacyl)]-13-[(4S,5R)-4-aryl-2-substituted-3-(2-substituted-2-trialkylsilyl)ethoxycarbonyl-1, 3-oxazolidinyl-5-carbonyl-10-deacetylbaccatin III 7b with tetraalkylammonium halide in a haloalkane to obtain free amine of structure 8; treating free amine 8 with acid chloride or acid anhydride in the presence of a base in a heterogeneous phase to obtain the intermediates of structure 9; subjecting the intermediates of compound 9 to the deprotection of 2-haloacyl group under mild alkaline condition at −20 to +40° C. for 6-24 h in the presence of ammonia or aliphatic amines or aromatic amines or their combination to obtain paclitaxel or docetaxel.

    摘要翻译： 本发明涉及一种制备紫杉烷的方法，包括将7,10-双保护的中间体7-O-（2-卤代酰基）浆果赤霉素III 6c或7,10-O-二（2-卤代酰基）-10-脱乙酰基浆果赤霉素III 6b （4S，5R）-3 - [（2-烷基/芳基-2-三烷基甲硅烷基）乙氧基 - 羰基] -4-芳基-2-取代-1,3-唑烷-5-羧酸1 在缩合剂，活化剂和芳烃存在下，得到7-O- [2-（卤代酰基）] - 13 - [（4S，5R）-4-芳基-2-取代-3（2- 未取代的/取代的2-三烷基甲硅烷基） - 乙氧基羰基-1,3-恶唑烷基-5-羰基]浆果赤霉素III 7a或7,10-二-O- [2-（卤代酰基）] - 13 - [（4S，5R）-4 （2-未取代的/取代的2-三烷基甲硅烷基）乙氧基羰基-1,3-恶唑烷基-5-羰基] -10-脱乙酰基浆果赤霉素III 7b; 处理偶联产物7-O- [2-（卤代酰基）] - 13 - [（4S，5R）-4-芳基-2-取代-3-（2-取代-2-三烷基甲硅烷基）乙氧羰基-1 3-恶唑烷基-5-羰基]浆果赤霉素III 7a或7,10-二-O- [2 [（卤代酰基）] - 13 - [（4S，5R）-4-芳基-2-取代-3- 取代的2-三烷基甲硅烷基）乙氧基羰基-1,3-恶唑烷基-5-羰基-10-脱乙酰基浆果赤霉素III 7b与四烷基卤化铵在卤代烷烃中反应，得到结构8的游离胺; 在碱存在下用酰氯或酸酐处理游离胺8，得到结构9的中间体; 使化合物9的中间体在温和碱性条件下在-20至+ 40℃下在氨或脂族胺或芳族胺或其组合的存在下将2-卤代酰基脱保护6-24小时，得到紫杉醇或 多西紫杉醇

    Distillation tower baffle
    92.
    发明申请
    Distillation tower baffle 有权
    蒸馏塔挡板

    公开(公告)号：US20070175746A1

    公开(公告)日：2007-08-02

    申请号：US11698099

    申请日：2007-01-26

    申请人： Arun Sharma ,  Theodore Sideropoulos ,  Rutton Patel ,  Brian Albert ,  Alvin Chen

    发明人： Arun Sharma ,  Theodore Sideropoulos ,  Rutton Patel ,  Brian Albert ,  Alvin Chen

    IPC分类号： B01D3/14

    CPC分类号： B01D45/08 ,  B01D1/305 ,  B01D3/32 ,  Y10S159/16

    摘要： An improved de-entrainment device for use in distillation towers, especially vacuum distillation towers used for fractionating petroleum atmospheric resids comprises a baffle which is to be located in the portion of the tower below the feed zone and at the top of the flash zone. The baffle is in the form of an apertured plate above the stripping zone and in its preferred form comprises number of radial fins or blades, resembling a static fan with openings between the fins to permit vapors from the lower portions of the tower to pass upwards through the baffle with a minimal pressure drop. The fins of the baffle are preferably oriented at an angle between 30° and 60° away from the incoming feed so that the incoming feed stream skims over the top edges of the fins.

    摘要翻译： 用于蒸馏塔，特别是用于分馏石油常压渣油的真空蒸馏塔的改进的去夹装置包括挡板，其位于进料区下方和闪蒸区顶部的塔的部分。 挡板是在汽提区上方的多孔板的形式，并且其优选形式包括数量的径向翅片或叶片，类似于在翅片之间具有开口的静态风扇，以允许来自塔的下部的蒸汽向上通过 挡板具有最小的压降。 挡板的翅片优选地与进料相比以30°和60°之间的角度取向，使得进入的进料流在翅片的顶部边缘上滑动。

    Adaptive vibration control for servo systems in data storage devices
    94.
    发明授权
    Adaptive vibration control for servo systems in data storage devices 失效
    数据存储设备伺服系统的自适应振动控制

    公开(公告)号：US06549349B2

    公开(公告)日：2003-04-15

    申请号：US09955391

    申请日：2001-09-18

    申请人： Sri Muthuthamby Sri-Jayantha ,  Arun Sharma ,  Hien Phu Dang ,  Naoyuki Kagami ,  Yuzo Nakagawa ,  Akira Tokizono ,  Isao Yoneda

    发明人： Sri Muthuthamby Sri-Jayantha ,  Arun Sharma ,  Hien Phu Dang ,  Naoyuki Kagami ,  Yuzo Nakagawa ,  Akira Tokizono ,  Isao Yoneda

    IPC分类号： G11B2736

    CPC分类号： G11B21/106 ,  G11B5/59611

    摘要： Methods and systems for detecting and correcting for undesirable vibrations impacting the servo systems in data storage devices. A detection technique is provided wherein a detection filter is configured to scan a position signal of the servo system across a range of frequencies, and, at each respective scanned frequency, record an amplitude associated therewith. The recorded amplitudes are examined to determine whether any exceed a threshold, thereby locating a peak frequency of the vibration. Using the detected peak frequency of the vibration, a corrective filter is configured to operate about the peak frequency of vibration, thereby reducing its impact on the position signal in the servo system. Optimum detection and correction filter structures are disclosed, as are techniques for addressing filter state vectors as initial conditions as the corrective filters are repeatedly engaged during successive settle-out and track follow cycles (between seeks), as are continuous adaptation techniques for changing vibration environments.

    摘要翻译： 用于检测和校正影响数据存储设备中的伺服系统的不期望的振动的方法和系统。 提供了一种检测技术，其中检测滤波器被配置为扫描频率范围内的伺服系统的位置信号，并且在每个相应的扫描频率处记录与之相关联的振幅。 检查记录的振幅以确定是否有超过阈值，从而定位振动的峰值频率。 使用检测到的振动峰值频率，校正滤波器被配置为围绕振动的峰值频率运行，从而减小其对伺服系统中位置信号的影响。 公开了最佳检测和校正滤波器结构，作为用于将滤波器状态向量寻址作为初始条件的技术，校正滤波器在连续的稳定和跟踪周期（寻找之间）期间重复接合），以及用于改变振动环境的连续自适应技术 。

    Increased and randomized output sampling to reduce positioning noise in a data storage system
    95.
    发明授权
    Increased and randomized output sampling to reduce positioning noise in a data storage system 失效
    增加和随机输出采样，以减少数据存储系统中的定位噪声

    公开(公告)号：US06181507B2

    公开(公告)日：2001-01-30

    申请号：US08692164

    申请日：1996-08-05

    申请人： Nobuyuki Kitazaki ,  Kiyoshi Satoh ,  Arun Sharma ,  Sri Muthuthamby Sri-Jayantha ,  Isao Yoneda

    发明人： Nobuyuki Kitazaki ,  Kiyoshi Satoh ,  Arun Sharma ,  Sri Muthuthamby Sri-Jayantha ,  Isao Yoneda

    IPC分类号： G11B5596

    CPC分类号： G11B5/59605 ,  G11B5/59627 ,  G11B5/5965

    摘要： A method and system for reducing positioning noise in a data storage system are provided. An access device is positioned over a data storage medium using a stream of bursts stored on the medium. The bursts are sensed at a frequency determined by the rate at which the medium is moved relative to a sensing device. Output positioning values are provided to position the access device at a frequency higher than the frequency at which the positioning bursts are sensed, and/or at random times. The random times may be calculated as random advances or delays from time points occurring at a fixed frequency.

    摘要翻译： 提供了一种用于降低数据存储系统中的定位噪声的方法和系统。 访问设备使用存储在介质上的突发流来定位在数据存储介质上。 以由介质相对于感测装置移动的速率确定的频率感测脉冲串。 提供输出定位值以将访问设备定位在高于感测定位脉冲串的频率的频率处和/或随机时间。 随机时间可以被计算为在固定频率发生的时间点的随机前进或延迟。

    Data center cooling method
    97.
    发明授权
    Data center cooling method 有权
    数据中心冷却方式

    公开(公告)号：US09107327B2

    公开(公告)日：2015-08-11

    申请号：US13551929

    申请日：2012-07-18

    申请人： Timothy J. Chainer ,  Hien P. Dang ,  Pritish R. Parida ,  Mark D. Schultz ,  Arun Sharma

    发明人： Timothy J. Chainer ,  Hien P. Dang ,  Pritish R. Parida ,  Mark D. Schultz ,  Arun Sharma

    IPC分类号： G05D23/00 ,  H05K7/20 ,  G06F1/20

    CPC分类号： H05K7/20836 ,  G06F1/206

    摘要： A method aspect for removing heat from a data center may use liquid coolant cooled without vapor compression refrigeration on a liquid cooled information technology equipment rack. The method may also include regulating liquid coolant flow to the data center through a range of liquid coolant flow values with a controller-apparatus based upon information technology equipment temperature threshold of the data center.

    摘要翻译： 从数据中心去除热量的方法方面可以使用液体冷却剂冷却而不进行蒸气压缩制冷在液冷信息技术设备机架上。 该方法还可以包括通过使用基于数据中心的信息技术设备温度阈值的控制器装置通过一定范围的液体冷却剂流量来调节流向数据中心的液体冷却剂流。

    Characterizing thermomechanical properties of an organic substrate using finite element analysis
    99.
    发明授权
    Characterizing thermomechanical properties of an organic substrate using finite element analysis 有权
    使用有限元分析表征有机基质的热机械性能

    公开(公告)号：US08345955B2

    公开(公告)日：2013-01-01

    申请号：US12260693

    申请日：2008-10-29

    申请人： Hien Phu Dang ,  Arun Sharma ,  Sri M. Sri-Jayantha

    发明人： Hien Phu Dang ,  Arun Sharma ,  Sri M. Sri-Jayantha

    IPC分类号： G06K9/00

    CPC分类号： G06F17/5018 ,  G06F2217/80

    摘要： A method for characterizing thermomechanical properties of an organic substrate is provided. The method includes the steps of: receiving an image of the organic substrate, the image including a geometric description of the plurality of circuit layers of the substrate; selecting a given one of the plurality of circuit layers for processing; converting the image to a two-dimensional finite element model (FEM) image of the given one of the circuit layers; determining at least one of a coefficient of thermal expansion (CTE), modulus and Poisson's ratio of the FEM image of the given one of the circuit layers; repeating the steps of selecting a given one of the plurality of circuit layers, converting the image to a two-dimensional FEM image, and determining at least one of a CTE, modulus and Poisson's ratio of the FEM image for all of the plurality of circuit layers corresponding to at least a portion of the organic substrate; and constructing a three-dimensional representation of at least a portion of the organic substrate including the plurality of circuit layers as a function of at least one of the CTE, modulus and Poisson's ratio of each of the plurality of circuit layers.

    摘要翻译： 提供了表征有机基板的热机械性能的方法。 该方法包括以下步骤：接收有机衬底的图像，该图像包括衬底的多个电路层的几何描述; 选择所述多个电路层中的给定一个以进行处理; 将图像转换成给定的一个电路层的二维有限元模型（FEM）图像; 确定给定一个电路层的FEM图像的热膨胀系数（CTE），模数和泊松比中的至少一个; 重复选择多个电路层中的给定的一个电路层的步骤，将图像转换为二维有机图像，以及确定所有多个电路中的有限元图像的CTE，模数和泊松比中的至少一个 对应于有机基材的至少一部分的层; 以及构成包括所述多个电路层的所述有机衬底的至少一部分的三维表示作为所述多个电路层中的每一个的CTE，模数和泊松比中的至少一个的函数。