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    Pancreatic Cancer Biomarkers and Uses Thereof
    91.
    发明申请
    Pancreatic Cancer Biomarkers and Uses Thereof 审中-公开
    胰腺癌生物标志物及其用途

    公开(公告)号：US20140073522A1

    公开(公告)日：2014-03-13

    申请号：US14020334

    申请日：2013-09-06

    申请人： SomaLogic, Inc.

    发明人： Stephen Alaric Williams ,  Michael Riel-Mehan ,  Rachel M. Ostroff

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N33/57438 ,  G16B20/00

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or pancreatic cancer specifically. In another aspect, methods are provided for diagnosing pancreatic cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having pancreatic cancer, or the likelihood of the individual having pancreatic cancer is determined, based on the at least one biomarker value. In a further aspect, methods are provided for diagnosing cancer generally in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer generally, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本公开内容包括用于癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒，特别是胰腺癌。 在一个方面，本公开提供可以单独使用或以各种组合使用的生物标志物，以特异性诊断癌症或胰腺癌。 在另一方面，提供了用于诊断个体中的胰腺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值 ，其中基于所述至少一种生物标志物值将所述个体分类为具有胰腺癌或确定具有胰腺癌的个体的可能性。 在另一方面，提供了用于一般在个体中诊断癌症的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于至少一种选自表中提供的生物标志物的生物标志物的生物标记值 19，其中，基于所述至少一种生物标记值，将所述个体一般分类为具有癌症或确定患有癌症的个体的可能性。

    Selection of Preferred Sample Handling and Processing Protocol for Identification of Disease Biomarkers and Sample Quality Assessment
    92.
    发明申请
    Selection of Preferred Sample Handling and Processing Protocol for Identification of Disease Biomarkers and Sample Quality Assessment 审中-公开
    选择优选的样品处理和鉴定疾病生物标志物的处理方案和样品质量评估

    公开(公告)号：US20130103321A1

    公开(公告)日：2013-04-25

    申请号：US13659755

    申请日：2012-10-24

    申请人： SomaLogic, Inc.

    发明人： Michael Riel-Mehan ,  Alex A.E. Stewart ,  Glenn Sanders ,  Rachel M. Ostroff ,  Stephen Alaric Williams ,  Edward N. Brody

    IPC分类号： G06F19/00

    CPC分类号： G06F19/34 ,  G16H10/40

    摘要： The subject invention relates to methods for obtaining biological samples of improved quality. It encompasses the identification of markers or proteins in biological samples that are altered due to variations in sample collection, handling and processing. They are also useful for correcting variations in measured results for disease biomarkers. Further, they can permit the rejection of samples or groups of samples as necessary if it is determined that their collection method was not in accordance with the predetermined protocol. Other advantages useful to the skilled artisan are described herein.

    摘要翻译： 本发明涉及获得质量提高的生物样品的方法。 它包括由于样品收集，处理和处理的变化而改变的生物样品中的标记物或蛋白质的鉴定。 它们也可用于校正疾病生物标志物的测量结果的变化。 此外，如果确定它们的收集方法不符合预定的方案，它们可以允许拒绝样品或样品组。 本文描述了对本领域技术人员有用的其它优点。

    Multiplexed Analyses of Test Samples
    96.
    发明申请
    Multiplexed Analyses of Test Samples 有权
    测试样本的多路复用分析

    公开(公告)号：US20100317120A1

    公开(公告)日：2010-12-16

    申请号：US12859930

    申请日：2010-08-20

    申请人： James R. Heil ,  Daniel J. Schneider ,  Daniel T. Nieuwlandt ,  Sheri K. Wilcox ,  Dominic Zichi ,  Todd Gander ,  Bruce Eaton ,  Larry Gold

    发明人： James R. Heil ,  Daniel J. Schneider ,  Daniel T. Nieuwlandt ,  Sheri K. Wilcox ,  Dominic Zichi ,  Todd Gander ,  Bruce Eaton ,  Larry Gold

    IPC分类号： G01N33/68

    CPC分类号： G01N33/54306 ,  C07B2200/11 ,  C12Q1/6832 ,  C12Q1/6834 ,  C12Q1/6837 ,  C40B40/00 ,  G01N33/58 ,  C12Q2537/101 ,  C12Q2525/205 ,  C12Q2523/313 ,  C12Q2525/161 ,  C12Q2565/514 ,  C12Q2565/101 ,  C12Q2541/101

    摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).

    摘要翻译： 本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。 在一个实施方案中，将测试样品与包含标签的适体接触并对靶分子具有特异性亲和力。 允许形成包含与其靶分子结合的适体的适体亲和复合体。 如果测试样品含有目标分子，通常将在测试样品中形成适体亲和复合体。 适体亲和复合物任选地转化为适体共价复合物，其包括与其靶分子共价结合的适体。 然后可以使用本领域技术人员已知的各种方法中的任一种检测和/或定量适体亲和复合物（或任选的适体共价复合物），包括使用固体支持物，使用质谱法和使用定量聚合酶链反应 （Q-PCR）。

    Ovarian Cancer Biomarkers and Uses Thereof
    97.
    发明申请
    Ovarian Cancer Biomarkers and Uses Thereof 审中-公开
    卵巢癌生物标志物及其用途

    公开(公告)号：US20100221752A2

    公开(公告)日：2010-09-02

    申请号：US12574341

    申请日：2009-10-06

    申请人： Larry Gold ,  Marty Stanton ,  Edward Brody ,  Rachel Ostroff ,  Dominic Zichi ,  Alex Stewart

    发明人： Larry Gold ,  Marty Stanton ,  Edward Brody ,  Rachel Ostroff ,  Dominic Zichi ,  Alex Stewart

    IPC分类号： G01N33/567 ,  G01N33/53 ,  G06F19/00 ,  G06F17/18

    CPC分类号： G01N33/57449 ,  G06F19/24 ,  Y10T436/143333

    摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign or malignant. In another aspect, methods are provided for diagnosing ovarian cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having ovarian cancer, or the likelihood of the individual having ovarian cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本申请包括用于卵巢癌的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 一方面，本申请提供可以单独使用或以各种组合使用以诊断卵巢癌或允许骨盆块的鉴别诊断为良性或恶性的生物标志物。 在另一方面，提供了用于诊断个体中的卵巢癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值 ，其中基于所述至少一种生物标志物值将所述个体分类为具有卵巢癌或确定具有卵巢癌的个体的可能性。

    Multiplexed Analyses of Test Samples
    98.
    发明申请
    Multiplexed Analyses of Test Samples 有权
    测试样本的多路复用分析

    公开(公告)号：US20090042206A1

    公开(公告)日：2009-02-12

    申请号：US12175446

    申请日：2008-07-17

    申请人： Daniel J. Schneider ,  Dan Nieuwlandt ,  Bruce Eaton ,  Marty Stanton ,  Shashi Gupta ,  Stephan Kraemer ,  Dominic Zichi ,  Larry Gold

    发明人： Daniel J. Schneider ,  Dan Nieuwlandt ,  Bruce Eaton ,  Marty Stanton ,  Shashi Gupta ,  Stephan Kraemer ,  Dominic Zichi ,  Larry Gold

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/5308 ,  C12Q1/6832 ,  C12Q1/6834 ,  C12Q2537/101 ,  C12Q2525/205 ,  C12Q2523/313 ,  C12Q2525/161

    摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

    摘要翻译： 本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。 所描述的方法，装置，试剂盒和试剂通过检测和定量核酸（即，适体）促进了测试样品中非核酸靶标（例如，蛋白质靶标）的检测和定量。 所描述的方法为非核酸靶产生了核酸替代物，从而允许将广泛种类的核酸技术（包括扩增）应用于更广泛的期望目标，特别是蛋白质靶标。 本公开进一步描述了适于在各种分析检测应用中促进适配体使用的适体构建体。

    Methods and Reagents for Detecting Target Binding by Nucleic Acid Ligands
    100.
    发明申请
    Methods and Reagents for Detecting Target Binding by Nucleic Acid Ligands 有权
    用于检测核酸配体靶标结合的方法和试剂

    公开(公告)号：US20080160535A1

    公开(公告)日：2008-07-03

    申请号：US12030024

    申请日：2008-02-12

    申请人： Larry Gold ,  Jonathan Drew Smith ,  Dominic Zichi ,  Daniel J. Schneider ,  Chad Greef

    发明人： Larry Gold ,  Jonathan Drew Smith ,  Dominic Zichi ,  Daniel J. Schneider ,  Chad Greef

    IPC分类号： C12Q1/68 ,  C40B60/10 ,  C07H21/04

    CPC分类号： C12N15/115 ,  G01N33/58

    摘要： The present invention provides novel methods and reagents for detecting the binding of protein targets to nucleic acid ligands. Using Universal Protein Stains (UPS), proteins bound by nucleic acid ligands may be labeled with a detectable moiety. The methods and reagents are particularly useful for the detection of protein targets bound to multiplexed arrays of nucleic acid ligands. The present invention also provides novel methods for the multiplexed evaluation of photocrosslinking nucleic acid ligands. The methods allow one simultaneously to: (1) evaluate the performance (dynamic range) of a plurality of photocrosslinking nucleic acid ligands; and (2) assess the specificity of each photocrosslinking nucleic acid ligand for its cognate target protein. Photocrosslinking nucleic acid ligands with the most desirable properties can then be selected for use in diagnostic and prognostic medical assays. The present invention also provides a photocrosslinking nucleic acid ligand that binds specifically to HIV gp120MN.

    摘要翻译： 本发明提供用于检测蛋白质靶标与核酸配体的结合的新型方法和试剂。 使用通用蛋白污渍（UPS），可以用可检测的部分标记由核酸配体结合的蛋白质。 所述方法和试剂对于检测与核酸配体复合阵列结合的蛋白质靶标特别有用。 本发明还提供了用于光交联核酸配体的多重评价的新方法。 该方法同时允许：（1）评估多个光交联核酸配体的性能（动态范围）; 和（2）评估每个光交联核酸配体对其同源靶蛋白的特异性。 然后可以选择具有最理想特性的光交联核酸配体用于诊断和预后医学测定。 本发明还提供了与HIV gp120MN特异性结合的光交联核酸配体。