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公开(公告)号：US20070224676A1
公开(公告)日：2007-09-27
申请号：US11688491
申请日：2007-03-20
Applicant: Tariq A. Haq
Inventor： Tariq A. Haq
IPC: C12M1/24
Abstract: The present invention provides a roller bottle for cell growth culturing, the roller bottle including a bottom wall; a top wall having an opening formed therethrough; and, a side wall extending between the top and bottom walls, a plurality of corrugations being defined in the side wall. Further, a distance is defined between the top and bottom walls, and the corrugations are selectively deformable to alter the distance. Advantageously, with the present invention, a single roller bottle may be provided with its length being adjustable in response to cell culture size and density.
Abstract translation: 本发明提供一种用于细胞生长培养的滚瓶，所述滚瓶包括底壁; 顶壁，其具有通过其形成的开口; 以及在顶壁和底壁之间延伸的侧壁，在侧壁中限定多个波纹。 此外，在顶壁和底壁之间限定距离，并且波纹可选择性地变形以改变距离。 有利地，通过本发明，可以提供单个辊瓶，其长度可响应于细胞培养物的尺寸和密度而调节。
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公开(公告)号：US20070178589A1
公开(公告)日：2007-08-02
申请号：US11709933
申请日：2007-02-22
Applicant: John Wilson
Inventor： John Wilson
CPC classification number: C12M23/24 , C12M23/26 , C12M23/34 , C12M25/14 , C12M33/04 , C12M41/44 , C12M47/20
Abstract: A disclosure is made of various apparatus and methods for culturing and preserving cells and tissue in ways that minimize contamination potential, direct cells to reside in desired areas, allow uniform cell distribution during seeding, provide optimal growth conditions by controlling the amount of medium residing in proximity of cells, allow desired compounds and molecules to reside in proximity of the cells, allow co-culture, provide for efficient scale up, allow a desired shape of tissue to be created while retaining a closed system, and allow cryopreservation and reconstitution of cell and tissue while retaining a closed system. The apparatus and methods can be combined to prevent the need to remove the tissue from the enclosure at any point during the sterilization, seeding, culturing, cryopreservation, shipping, or restoration process. Also disclosed is an apparatus and method of pipette interface with a container in a manner that blocks contaminants from entering the container.
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公开(公告)号：US07229820B2
公开(公告)日：2007-06-12
申请号：US10460850
申请日：2003-06-13
Applicant: John R. Wilson
Inventor： John R. Wilson
IPC: C12M1/00
CPC classification number: C12M23/24 , C12M23/26 , C12M23/34 , C12M25/14 , C12M33/04 , C12M41/44 , C12M47/20
Abstract: A disclosure is made of various apparatus and methods for culturing and preserving cells and tissue in ways that minimize contamination potential, direct cells to reside in desired areas, allow uniform cell distribution during seeding, provide optimal growth conditions by controlling the amount of medium residing in proximity of cells, allow desired compounds and molecules to reside in proximity of the cells, allow co-culture, provide for efficient scale up, allow a desired shape of tissue to be created while retaining a closed system, and allow cryopreservation and reconstitution of cell and tissue while retaining a closed system. The apparatus and methods can be combined to prevent the need to remove the tissue from the enclosure at any point during the sterilization, seeding, culturing, cryopreservation, shipping, or restoration process. Also disclosed is an apparatus and method of pipette interface with a container in a manner that blocks contaminants from entering the container.
Abstract translation: 公开了用于以最小化污染潜力的方式培养和保存细胞和组织的各种装置和方法，使细胞驻留在期望的区域中，允许在播种期间均匀的细胞分布，通过控制驻留在培养基中的培养基的量来提供最佳的生长条件 接近细胞，使所需的化合物和分子驻留在细胞附近，允许共培养，提供有效的放大，允许在保留封闭系统的同时产生所需形状的组织，并允许冷冻保存和重建细胞 和组织，同时保持封闭系统。 可以组合装置和方法，以防止在灭菌，播种，培养，冷冻保存，运送或恢复过程中的任何时间将组织从外壳中移出。 还公开了以阻止污染物进入容器的方式与容器移液管接口的装置和方法。
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公开(公告)号：US20040229348A1
公开(公告)日：2004-11-18
申请号：US10841029
申请日：2004-05-07
Inventor： Wolfgang Kahlert , Bernd-Ulrich Wilhelm , Rainer Salzmann , Wolfgang Rietschel
IPC: C12M003/00
Abstract: A device and a method for the cultivation of cells is disclosed that utilizes external pneumatic pressure responsive to liquid level sensors to gently recirculate and cause turbulence in cell growth medium to promote cell growth without any shearing action and without a stir motor or mechanical manipulation means.
Abstract translation: 公开了一种用于培养细胞的装置和方法，其利用响应于液位传感器的外部气动压力轻轻地再循环并引起细胞生长培养基中的湍流，以促进细胞生长而没有任何剪切作用，而不需要搅拌马达或机械操纵装置。
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公开(公告)号：US06391638B1
公开(公告)日：2002-05-21
申请号：US09246600
申请日：1999-02-08
Applicant: Yoseph Shaaltiel
Inventor： Yoseph Shaaltiel
IPC: C12N500
Abstract: A disposable device and method for axenically culturing and harvesting cells and/or tissue in consecutive cycles. The device consists of a sterilisable disposable container which may be partially filled with a suitable sterile biological cell and/or tissue culture medium. The container has means for removing excess air and/or waste gases therefrom, and means for introducing inoculant and/or culture medium and/or additives therein. A reusable harvesting means enables harvesting of at least a portion of the medium containing cells and/or tissue when desired, thereby enabling the device to be used continuously for at least one subsequent consecutive culturing/harvesting cycle. The portion of medium containing cells and/or tissue remaining from a previously harvested cycle may serve as inoculant for a next culture and harvest cycle.
Abstract translation: 一种用于在连续循环中进行细胞和/或组织的细胞培养和收获的一次性装置和方法。 该装置由可灭菌的一次性容器组成，其可以部分地填充有合适的无菌生物细胞和/或组织培养基。 容器具有用于从其中除去多余的空气和/或废气的装置，以及用于在其中引入孕育剂和/或培养基和/或添加剂的装置。 可重复使用的收获装置能够在需要时收集含有细胞和/或组织的至少一部分培养基，从而使得该装置能够连续使用至少一个随后的连续培养/收获循环。 从先前收获的循环中残留的含有细胞和/或组织的培养基的部分可以用作下一个培养和收获循环的接种剂。
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公开(公告)号：US5104803A
公开(公告)日：1992-04-14
申请号：US163800
申请日：1988-03-03
Applicant: Jacques Delente
Inventor： Jacques Delente
IPC: C12M1/00
Abstract: The present invention relates to a photobioreactor for the cultivation of photosynthetic micoorganisms having at least one light bank substantially totally immersible in the liquid microbial culture contained in the photobioreactor so that substantially all of the emitted light is absorbed in the culture. The light bank comprises a plurality of light tubes in substantially close proximity to each other, electrical leads extending from the light tubes to a source of electric power and an enclosure means enclosing at least the portions of the electrical leads into the lead tubes to render such points impervious to the liquid microbial culture. The light bank serves as a light source as well as may be arranged to form channels for the circulation of the liquid culture within the photobioreactor.
Abstract translation: 本发明涉及一种用于培养光合微生物的光生物反应器，其具有基本上完全浸没在光生物反应器中的液体微生物培养物中的至少一个光组，使得基本上所有的发射光在培养物中被吸收。 光库包括彼此基本上非常接近的多个光管，从光管延伸到电源的电引线以及将电引线的至少一部分包围到引线管中的外壳装置， 不渗透液体微生物培养的点。 光库用作光源，并且可以被布置成形成用于光生物反应器内的液体培养物循环的通道。
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107.发明授权Apparatus for measuring the approximate number of aerobic bacteria in water and other fluids 失效用于测量水和其他液体中需氧细菌近似数量的装置
公开(公告)号：US4263405A
公开(公告)日：1981-04-21
申请号：US57237
申请日：1979-07-13
Applicant: Joseph L. Melnick , Craig Wallis
Inventor： Joseph L. Melnick , Craig Wallis
IPC: C12M1/34
CPC classification number: C12M41/36 , C12M41/40 , C12M41/44 , Y10S435/807
Abstract: A simple and functional apparatus is disclosed for use in the home, field and other places in which water or other fluids can be evaluated for the presence of bacteria. Also disclosed is a convenient tablet reagent for use with liquid peroxide with the apparatus.
Abstract translation: 公开了用于家庭，场地和其他水或其它流体可以评价细菌存在的地方的简单且功能性的设备。 还公开了与该装置一起用于与液体过氧化物一起使用的方便的片剂试剂。
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公开(公告)号：US3594277A
公开(公告)日：1971-07-20
申请号：US3594277D
申请日：1968-04-23
Applicant: ATLANTIC RICHFIELD CO
Inventor： MAKO PETER F
CPC classification number: C12M27/06 , C12M27/22 , C12M41/12 , C12M41/44 , Y10S435/804
Abstract: A FERMENTOR COMPRISING A NORMALLY HORIZONTAL CYLINDRICAL CHAMBER HAVING CLOSED ENDS AND INCLUDING A PLURALITY OF APERTURED DISCS ROTATABLY MOUNTED IN THE CYLINDER, INLET CONDUITS FOR BIOLOGBICAL NUTRIENTS AND AIR ONE END OF THE CLOSED CYLINDER AND CONDUITS FOR REMOVING AIR, SPENT NUTRIENTS AND BIOLOGICAL PRODUCTS AT THE OTHER END OF THE CYLINDER, THE DISCS BEING ADAPTED FOR CONTINUOUSLY ROTATABLY CARRYING PORTIONS OF LIQUID NUTRIENT FROM THE
BOTTOM OF THE CYLINDER INTO A GAS PHASE AT THE TOP OF THE CYLINDER, IS DISCLOSED.
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公开(公告)号：US20240301335A1
公开(公告)日：2024-09-12
申请号：US18180702
申请日：2023-03-08
Applicant: Lillianah Technologies Inc.
Inventor： Benjamin Sidney Slotnick , Tarynn Daye Brewer
CPC classification number: C12M21/02 , A01G33/00 , C12M31/10 , C12M41/06 , C12M41/36 , C12M41/44 , C12M41/48 , C12N1/12
Abstract: A photobioreactor system includes a frame, a reflective wall coupled to the frame such that the reflective wall defines and circumferentially surrounds an interior chamber, and multiple light sources coupled to the reflective wall such that the multiple light sources circumferentially surround the interior chamber. The interior chamber is configured to receive a container that holds and supports growth of a desired organism.
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公开(公告)号：US20240191204A1
公开(公告)日：2024-06-13
申请号：US18391053
申请日：2023-12-20
Applicant: Cellino Biotech, Inc.
Inventor： Matthias WAGNER , Suvi AIVIO , Mariangela AMENDUNI , Catherine PILSMAKER , Arnaldo PEREIRA , Ananya ZUTSHI , Anthia TOURE , Steven NAGLE , Ozge WHITING , George HARB , Matthew SULLIVAN , Maya BERLIN-UDI , Stefanie MORGAN , Nick SEAY , Sang LEE , Scott LURO
IPC: C12N5/074 , B01L3/00 , B01L9/00 , C12M1/00 , C12M1/06 , C12M1/12 , C12M1/26 , C12M1/34 , C12M1/36 , C12M3/00 , C12N5/00 , G01N15/10 , G01N15/14 , G01N15/1429 , G01N15/1433 , G01N15/1434 , G06T7/00
CPC classification number: C12N5/0696 , B01L3/502715 , B01L3/502761 , B01L9/52 , C12M23/14 , C12M23/22 , C12M23/26 , C12M23/28 , C12M23/42 , C12M23/44 , C12M23/48 , C12M25/06 , C12M27/02 , C12M29/02 , C12M31/02 , C12M33/00 , C12M33/12 , C12M41/12 , C12M41/26 , C12M41/44 , C12M41/46 , C12M41/48 , C12M47/04 , C12N5/0081 , G01N15/1023 , G01N15/1429 , G01N15/1433 , G01N15/1434 , G06T7/0012 , G06T7/0016 , B01L2200/18 , B01L2300/0663 , B01L2300/0877 , C12M41/36 , G01N2015/1006 , G01N2015/1452 , G01N2015/1454 , G01N2015/1486 , G06T2207/10056 , G06T2207/10064 , G06T2207/20081 , G06T2207/30024 , G06T2207/30072
Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
