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公开(公告)号：US10966968B2
公开(公告)日：2021-04-06
申请号：US14298673
申请日：2014-06-06
发明人： Rene Braeckman , William Stirtan , Paresh Soni
IPC分类号： A61K31/4439 , A61K31/557 , A61K31/202
摘要： In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing triglycerides in a subject on rosiglitazone therapy, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
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112.发明申请公开(公告)号：US20210085629A1
公开(公告)日：2021-03-25
申请号：US17074505
申请日：2020-10-19
IPC分类号： A61K31/202 , A61K31/40
摘要： In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing or preventing sdLDL oxidation in a subject, the method comprising administering to the subject a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
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公开(公告)号：US10888539B2
公开(公告)日：2021-01-12
申请号：US15703782
申请日：2017-09-13
发明人： Joseph S. Zakrzewski
IPC分类号： A61K31/232 , A61K31/202 , A61K45/06
摘要： In various embodiments, the present invention provides methods of treating and/or preventing prostate cancer and, in particular, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
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公开(公告)号：US10881632B2
公开(公告)日：2021-01-05
申请号：US16894567
申请日：2020-06-05
发明人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
IPC分类号： A61K31/202 , A61K9/48 , A61P3/06 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/00 , A61K31/232 , A61K45/06
摘要： The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
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115.发明授权公开(公告)号：US10851374B2
公开(公告)日：2020-12-01
申请号：US16189151
申请日：2018-11-13
发明人： Joseph S. Zakrzewski
IPC分类号： C12N15/113 , A61K31/232 , A61K31/7125 , A61K9/00 , A61K9/08 , A61K31/202
摘要： The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
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公开(公告)号：US10792267B2
公开(公告)日：2020-10-06
申请号：US16389317
申请日：2019-04-19
发明人： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
IPC分类号： A61K31/202 , A61K45/06 , A61K31/222 , A61K31/232 , A61K31/40 , A61K31/505 , A61K9/48 , A61K47/22 , A61K47/26 , A61K47/34 , A61K31/74 , A61P3/06
摘要： The present disclosure relates to, inter alia, methods of treating cardiovascular-related disease.
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117.发明授权公开(公告)号：US10555924B2
公开(公告)日：2020-02-11
申请号：US16502621
申请日：2019-07-03
发明人： Paresh Soni
IPC分类号： A61K31/232 , A61K45/06 , A61K31/397
摘要： In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
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118.发明授权公开(公告)号：US10314803B2
公开(公告)日：2019-06-11
申请号：US13705990
申请日：2012-12-05
发明人： Mehar Manku
IPC分类号： A61K31/202 , A61K31/232 , A61K45/06 , A61K31/455
摘要： The present invention relates to, inter alia, pharmaceutical compositions comprising eicosapentaenoic acid and/or derivatives thereof and nicotinic acid, to methods of manufacturing such compositions, and to therapeutic methods for treating carious diseases and disorders.
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公开(公告)号：US09918955B2
公开(公告)日：2018-03-20
申请号：US15607084
申请日：2017-05-26
发明人： Paresh Soni
IPC分类号： A61K31/232 , A61K31/397 , A61K45/06
CPC分类号： A61K31/232 , A61K31/397 , A61K45/06 , A61K2300/00
摘要： In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
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公开(公告)号：US20140275252A1
公开(公告)日：2014-09-18
申请号：US14210836
申请日：2014-03-14
发明人： Joseph S. Zakrzewski
IPC分类号： A61K31/232 , A61K31/202
CPC分类号： A61K31/232 , A61K31/202 , A61K2300/00
摘要： The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent traumatic brain injuries.
摘要翻译： 本发明尤其涉及包含多不饱和脂肪酸的药物组合物及其使用方法来治疗或预防创伤性脑损伤。
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