Growth hormone releasing peptides
    121.
    发明授权
    Growth hormone releasing peptides 有权
    生长激素释放肽

    公开(公告)号:US07456253B2

    公开(公告)日:2008-11-25

    申请号:US10484473

    申请日:2003-08-08

    申请人: Zheng Xin Dong

    发明人: Zheng Xin Dong

    IPC分类号: A61K38/04 A61K38/00

    摘要: Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R1-A2-A3-A4-A5-R2 (I) or a pharmaceutically acceptable salt thereof, wherein: A1 is Aib, Apc or Inp; A2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A4 is 2Fua, Om, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A5 is Apc, Dab, Dap, Lys, Orn, or deleted; R1 is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-10)acyl; and R2 is OH or NH2; and pharmaceutical compositions and methods of use thereof.

    摘要翻译: 公开了通常根据式(I)的肽和拟肽化合物及其药学上可接受的盐,其可用作GHRP类似物:R 1 -A 2 -O 2 (I)或其药学上可接受的盐,其中:A SUP> 1 是Aib,Apc或Inp; D-Bip,D-Bpa,D-Dip,D-1Nal,D-2Nal,D-Ser(Bzl)或D-Trp; D-Bip,D-Bpa,D-Dip,D-1Nal,D-2Nal,D-Ser(Bzl)或D-Trp; A 4是2Fua,Om,2Pal,3Pal,4Pal,Pff,Phe,Pim,Taz,2Thi,3Thi,Thr(Bzl); Apc,Dab,Dap,Lys,Orn,或缺失; R 1是氢,(C 1-6)烷基,(C 5-14)芳基,(C 1-6)烷基(C 5-14)芳基,(C 3-8)环烷基或(C 2 -C 6) 10)酰基; 且R 2是OH或NH 2; 和药物组合物及其使用方法。

    GLP-1 analogues
    122.
    发明授权
    GLP-1 analogues 失效
    GLP-1类似物

    公开(公告)号:US07368427B1

    公开(公告)日:2008-05-06

    申请号:US09856676

    申请日:1999-12-07

    IPC分类号: A61K38/26 C07K14/605

    摘要: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.

    摘要翻译: 本发明涉及胰高血糖素样肽-1的肽类似物,其药学上可接受的盐,涉及使用这些类似物治疗哺乳动物的方法以及包含所述类似物的药物组合物。

    Method and apparatus for extending memory addressing
    123.
    发明授权
    Method and apparatus for extending memory addressing 失效
    扩展存储器寻址的方法和装置

    公开(公告)号:US07310698B2

    公开(公告)日:2007-12-18

    申请号:US11304099

    申请日:2005-12-14

    IPC分类号: G06F12/00

    CPC分类号: G06F12/0623

    摘要: Techniques for extending memory addressing with more accessing range are disclosed. According to one aspect of the techniques, an apparatus for extending addressing space comprises a plurality of extended memories, each being allocated an unique identifier, a direct addressing memory reserving a data cell as a public identifier cell for receiving the identifier of each of the extended memories to be accessed, a decision unit determining that which one of the extended memories is to be accessed by comparing an identifier received by the public identifier cell with the identifier of each of the extended memories, and a mapping unit mapping one of the extended memories determined by the decision unit to be accessed onto the direct addressing memory so that the one of the extended memories can be indirectly accessed by directly accessing the direct addressing memory.

    摘要翻译: 公开了用于扩展具有更多访问范围的存储器寻址的技术。 根据该技术的一个方面,用于扩展寻址空间的装置包括多个扩展存储器,每个扩展存储器被分配唯一的标识符,将数据单元保留为公共标识符单元的直接寻址存储器,用于接收每个扩展的标识符的标识符 要访问的存储器,决定单元,通过将由公共标识符单元接收到的标识符与每个扩展存储器的标识符进行比较,确定要访问哪个扩展存储器;以及映射单元,映射扩展存储器之一 由决定单元确定要被访问到直接寻址存储器,使得可以通过直接访问直接寻址存储器间接地访问扩展存储器之一。

    Analogues of GLP-1
    124.
    发明授权
    Analogues of GLP-1 失效
    GLP-1的类似物

    公开(公告)号:US07268213B2

    公开(公告)日:2007-09-11

    申请号:US10629261

    申请日:2003-07-28

    申请人: Zheng Xin Dong

    发明人: Zheng Xin Dong

    IPC分类号: C07K14/605

    CPC分类号: C07K14/605 A61K38/00

    摘要: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.

    摘要翻译: 本发明涉及胰高血糖素样肽-1的肽类似物,其药学上可接受的盐,涉及使用这些类似物治疗哺乳动物的方法以及包含所述类似物的药物组合物。

    MINIMAL DIFFERENCE QUERY AND VIEW MATCHING
    125.
    发明申请
    MINIMAL DIFFERENCE QUERY AND VIEW MATCHING 审中-公开
    最小差异查询和查看匹配

    公开(公告)号:US20070192297A1

    公开(公告)日:2007-08-16

    申请号:US11558029

    申请日:2006-11-09

    IPC分类号: G06F17/30

    摘要: The subject disclosure pertains to efficient computation of the difference between queries by exploiting commonality between them. A minimal difference query (MDQ) is generated that roughly corresponds to removal of as many joins as possible while still accurately representing the query difference. The minimal difference can be employed to further substantially the scope of view matching where a query is not wholly subsumed by a view. Additionally, the minimal difference query can be employed as an analytical tool in various contexts.

    摘要翻译: 本发明涉及通过利用它们之间的共性来有效地计算查询之间的差异。 生成最小差异查询(MDQ),大致对应于删除尽可能多的连接,同时仍准确地表示查询差异。 可以使用最小差异来进一步实质地观察视图匹配的范围,其中查询未被完全包含在视图中。 另外,最小差异查询可以用作各种上下文中的分析工具。

    Inventory management system and methods for secure identification document issuance
    126.
    发明授权
    Inventory management system and methods for secure identification document issuance 失效
    库存管理系统和安全识别文件的发布方法

    公开(公告)号:US07131585B2

    公开(公告)日:2006-11-07

    申请号:US11014195

    申请日:2004-12-15

    IPC分类号: G06F19/00 G06Q30/00 G06Q90/00

    CPC分类号: G06Q10/087 G06Q20/203

    摘要: An inventory management system tracks consumables used in creation of secure documents through an identification document issuance process. The system assigns states to card and non-card consumables, and these states are used to track consumables from the vendor's inventory to the issuer's inventory. The system includes functions for managing inventory, shipping and receiving, use management, inventory auditing and secure material destruction. Electronic packing lists are transmitted between vendor and issuer systems to verify shipments. Embedded identification numbers, carried in machine readable codes on consumables, are used to track consumables through the document creation and issuing process.

    摘要翻译: 库存管理系统通过识别文档发布过程跟踪用于创建安全文档的耗材。 系统将状态分配给卡和非卡消耗品,这些状态用于跟踪从供应商的库存到发行人的库存的耗材。 该系统包括管理库存,运输和接收,使用管理,库存审核和安全材料销毁的功能。 供应商和发行者系统之间传送电子装箱单,以验证装运。 通过耗材上的机器可读代码携带的嵌入式识别号码用于通过文档创建和发布过程跟踪耗材。

    Analogs of parathyroid hormone
    127.
    发明授权

    公开(公告)号:US06544949B1

    公开(公告)日:2003-04-08

    申请号:US09399499

    申请日:1999-09-20

    申请人: Zheng Xin Dong

    发明人: Zheng Xin Dong

    IPC分类号: A61K3829

    摘要: The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.

    Analogs of parathyroid hormone
    128.
    发明授权
    Analogs of parathyroid hormone 失效
    甲状旁腺激素类似物

    公开(公告)号:US5969095A

    公开(公告)日:1999-10-19

    申请号:US779768

    申请日:1997-01-07

    申请人: Zheng Xin Dong

    发明人: Zheng Xin Dong

    CPC分类号: C07K14/635 A61K38/00

    摘要: Peptide variants of fragment (1-34) of parathyroid hormone, in which at least one of the amino acid residues at positions 7, 11, 23, 24, 27, 28, and 31 is cyclohexylalanine, or at least one of the amino acid residues at positions 3, 16, 17, 18, 19, and 34 is .alpha.-aminoisobutyric acid; or, alternatively, at least the amino acid residue at position 1 is .alpha.,.beta.-diaminopropionic acid, the amino acid residue at position 27 is homoarginine, or the amino acid residue at position 31 is norleucine.

    摘要翻译: 甲状旁腺激素片段(1-34)的肽变体,其中7,11,23,24,27,28和31位的至少一个氨基酸残基是环己基丙氨酸,或至少一种氨基酸 3,16,17,18,19和34位的残基是α-氨基异丁酸; 或者,至少第1位的氨基酸残基是α,β-二氨基丙酸,27位的氨基酸残基是高精氨酸,或者31位的氨基酸残基是正亮氨酸。

    Method for measuring inside dimensions of shoes and measuring tool therefor

    公开(公告)号:US09700104B2

    公开(公告)日:2017-07-11

    申请号:US15189082

    申请日:2016-06-22

    申请人: Xin Dong

    发明人: Xin Dong

    IPC分类号: A43D1/06 A43D1/02

    CPC分类号: A43D1/06 A43D1/02

    摘要: Disclosed is a method for measuring inside dimensions of shoes. In this method a foot model can be obtained after the processes of a plastic filling material being filled into the shoe, shaping, being taken out from the shoe and being restored; then more accurate data of the inside dimensions of the shoe can be obtained by measuring the foot model. Further disclosed is a measuring tool able to be used in the present measuring method. By using the measuring method and the measuring tool, errors encountered when going shopping for shoes can be reduced to the maximum degree by a simple operation, such that the problem that an ordinary consumer could buy a pair of perfect fitting shoes only if he/she tries them personally can be solved.

    Melanocortin receptor ligands
    130.
    发明授权
    Melanocortin receptor ligands 有权
    黑皮质素受体配体

    公开(公告)号:US09458195B2

    公开(公告)日:2016-10-04

    申请号:US13074565

    申请日:2011-03-29

    摘要: The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.

    摘要翻译: 本发明涉及下列化合物:ƒ€ƒ€ƒ€ƒ€ƒ€ƒAc-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp -Cys)-NH 2及其药学上可接受的盐。 该化合物作为一种或多种黑皮质素受体的配体。 本发明还涉及使用该化合物治疗哺乳动物的方法和包含所述化合物的药物组合物。