公开(公告)号：US08755858B2

公开(公告)日：2014-06-17

申请号：US12866308

申请日：2009-02-06

申请人： Masahiro Kitagawa ,  Masaki Fujiwara ,  Keisuke Matsumura

发明人： Masahiro Kitagawa ,  Masaki Fujiwara ,  Keisuke Matsumura

IPC分类号： A61B5/05

CPC分类号： A61B5/441 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/6843

摘要： Provided are a blood sensor that is highly reliable and does not contaminate the interior of the main body of the device, a blood testing device and a blood analysis method. The blood sensor is provided with a plate-shaped base, a blood storage part set roughly in the center of the base, a supply path, one end of which is connected to the storage part and the other end of which is connected to an air pore, multiple detecting electrodes laid on one surface of the supply path connecting electrodes, each coming out of these detection electrodes, and skin detection electrodes in the storage part or near the storage part. The blood detecting device is provided with a skin detecting circuit that detects skin contact by measuring sensor conduction or impedance changes.

摘要翻译： 提供一种高度可靠的血液传感器，并且不会污染装置的主体内部，血液检查装置和血液分析方法。 血液传感器设置有板状基部，大致位于基部的中心的血液存储部，供给路径，其一端与存储部连接，另一端与空气连接 放置在供应路径连接电极的一个表面上的多个检测电极，每个检测电极都从这些检测电极出来，以及皮肤检测电极在存储部分或存储部分附近。 血液检测装置设置有皮肤检测电路，其通过测量传感器传导或阻抗变化来检测皮肤接触。

公开(公告)号：US08540864B2

公开(公告)日：2013-09-24

申请号：US12829077

申请日：2010-07-01

申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

IPC分类号： G01N27/327

CPC分类号： G01N27/3274 ,  C12Q1/001 ,  C12Q1/006 ,  G01N33/66 ,  G01N33/728

摘要： The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The sensor for measuring a component in blood has a first analysis portion and a second analysis portion. The first analysis portion has a first electrode system (11,12) and a reagent layer (14), and the reagent layer (14) has an oxidoreductase that acts on the component and a mediator. In the first analysis portion, the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and detecting a redox current caused when a voltage is applied by the first electrode (11,12). The second analysis portion has a working electrode and a counter electrode, and a mediator is provided on the counter electrode but not on the working electrode. In the second analysis portion, a Hct value of the blood is measured by supplying the blood to the electrode system, applying a voltage to cause a current to flow, and detecting a value of the current. Using this Hct value, the amount of the component is corrected.

摘要翻译： 本发明提供了一种测量血液中的成分的方法，通过以高精度和高可靠性测量血液的血细胞比容（Hct）值，能够精确地校正成分的量，并且还提供了该方法中使用的传感器 。 用于测量血液中成分的传感器具有第一分析部分和第二分析部分。 第一分析部分具有第一电极系统（11,12）和试剂层（14），并且试剂层（14）具有作用于组分的氧化还原酶和介体。 在第一分析部分中，通过在介体存在下引起组分与氧化还原酶的氧化还原反应并检测当通过第一电极（11,12）施加电压时引起的氧化还原电流来测量血液中的组分， 。 第二分析部分具有工作电极和对电极，并且在对电极上而不是在工作电极上设置介体。 在第二分析部分中，通过将血液供给到电极系统，施加电压以使电流流动并检测电流的值来测量血液的Hct值。 使用此Hct值，校正组件的数量。

公开(公告)号：US08480867B2

公开(公告)日：2013-07-09

申请号：US13135848

申请日：2011-07-15

申请人： Shoji Miyazaki ,  Masaki Fujiwara ,  Yoshinobu Tokuno

发明人： Shoji Miyazaki ,  Masaki Fujiwara ,  Yoshinobu Tokuno

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

摘要： Apparatus are disclosed for measuring substrate content present in a specimen that is applied to a biosensor, where the apparatus include an input for receiving an electrical signal from the biosensor; and a circuit coupled to the input to detect the electrical signal to determine whether an amount of the specimen needed for specimen detection has been supplied to the biosensor; where the apparatus measures the substrate content included in the specimen when the circuit determines that an amount of the specimen needed for specimen detection has been supplied to the biosensor, and the apparatus is prevented from measuring the substrate content included in the specimen when the circuit determines that the specimen has not been sufficiently supplied to the biosensor.

摘要翻译： 公开了用于测量施加到生物传感器的样本中存在的底物含量的装置，其中装置包括用于从生物传感器接收电信号的输入端; 以及电路，其耦合到所述输入端以检测所述电信号，以确定是否向所述生物传感器提供了所述样本检测所需的样本量; 其中当电路确定样本检测所需的样本量已被提供给生物传感器时，该装置测量包含在样本中的基底含量，并且当电路确定时检测装置被测量包含在样本中的基底含量 样品没有被充分供应给生物传感器。

公开(公告)号：US08475646B2

公开(公告)日：2013-07-02

申请号：US13135816

申请日：2011-07-15

申请人： Shoji Miyazaki ,  Masaki Fujiwara ,  Yoshinobu Tokuno

发明人： Shoji Miyazaki ,  Masaki Fujiwara ,  Yoshinobu Tokuno

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

摘要： Methods are disclosed for measuring substrate content in a specimen using a biosensor that includes two pairs of electrodes in a specimen supply path, where the methods include the steps of: (a) a first detecting step for detecting an electrical change in the first pair of electrodes; (b) a second detecting step for detecting an electrical change in the second pair of electrodes after the first detecting step; (c) a judging step for judging a shortage of specimen amount that is needed for measurement, when an electrical change is not detected in the second detecting step within a prescribed period of time after the first detecting step; (d) an indicating step for indicating a shortage of the specimen amount; and (e) a stopping step for stopping measurement of substrate content in the specimen once the shortage of specimen amount is indicated in the indicating step.

摘要翻译： 公开了用于使用在样本供应路径中包括两对电极的生物传感器来测量样品中的基底含量的方法，其中所述方法包括以下步骤：（a）第一检测步骤，用于检测第一对中的电变化 电极 （b）第二检测步骤，用于在第一检测步骤之后检测第二对电极中的电变化; （c）当在第一检测步骤之后的规定时间内没有在第二检测步骤中检测到电变化时，判断测量所需的试样量的不足的判断步骤; （d）指示样本量不足的指示步骤; 和（e）一旦在指示步骤中指示了样本量不足，则停止步骤，用于停止测量样本中的基底含量。

公开(公告)号：US08469881B2

公开(公告)日：2013-06-25

申请号：US13133258

申请日：2009-10-15

申请人： Masaki Fujiwara ,  Yohei Hashimoto

发明人： Masaki Fujiwara ,  Yohei Hashimoto

IPC分类号： A61B5/15

CPC分类号： A61B5/150099 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150198 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15117 ,  A61B5/15136 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157

摘要： Provided are a decompression mechanism capable of performing a desired pressure reduction by simple operation and having improved operability, a puncture device, a blood analysis device, and a sensor mounting mechanism. A needle puncturing device (100) is provided with: a piston (121) having at one end thereof an end part (121a) for forming a part of a sensor mounting mechanism (130) and at the other end an end part (121b) for slidably supporting a rod (112) of a lancet section (111); a cylinder (122) for slidably containing therein the end section (121b) of the piston (121); and packing (125) mounted to the inner periphery of the end part (121b) of the piston (121) and maintaining the air-tightness of the outer periphery of the rod (112). When the piston (121) is moved in the direction toward the cylinder (122) with a skin contact part (131) in contact with the skin, the volumes of an internal space (140) and a pressure reduction chamber (150) which are sealed by packing (123, 124) are increased to produce a reduced pressure.

摘要翻译： 提供一种减压机构，其能够通过简单的操作和具有改进的可操作性，穿刺装置，血液分析装置和传感器安装机构来执行所需的压力降低。 针刺装置（100）具有：活塞（121），其一端具有用于形成传感器安装机构（130）的一部分的端部（121a），在另一端具有端部（121b） 用于可滑动地支撑柳叶刀部分（111）的杆（112）; 用于可滑动地容纳活塞（121）的端部（121b）的缸体（122）; 以及安装到所述活塞（121）的端部（121b）的内周并且保持所述杆（112）的外周的气密性的密封件（125）。 当活塞（121）沿着与皮肤接触的皮肤接触部分（131）朝向气缸（122）的方向移动时，内部空间（140）和减压室（150）的体积是 通过包装（123,124）密封，以产生减压。

公开(公告)号：US08349157B2

公开(公告)日：2013-01-08

申请号：US13490553

申请日：2012-06-07

申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

摘要： A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.

公开(公告)号：US08222448B2

公开(公告)日：2012-07-17

申请号：US13223605

申请日：2011-09-01

申请人： Jonathan Joachim Jodry ,  Masashi Nagamori ,  Yuji Hagiwara ,  Masaki Fujiwara ,  Satoru Narizuka

发明人： Jonathan Joachim Jodry ,  Masashi Nagamori ,  Yuji Hagiwara ,  Masaki Fujiwara ,  Satoru Narizuka

IPC分类号： C07C69/54

CPC分类号： C07C309/17 ,  C07C29/147 ,  C07C67/08 ,  C07C67/14 ,  C07C303/32 ,  C07C309/08 ,  C07C309/12 ,  C07C313/04 ,  C07C381/12 ,  C07C2602/42 ,  C07C2603/74 ,  G03F7/0045 ,  G03F7/0046 ,  C07C31/34 ,  C07C69/653 ,  C07C69/63 ,  C07C69/753

摘要： Disclosed is a process for producing 2-bromo-2,2-difluoroethanol, which comprises reducing a bromodifluoroacetic acid derivative represented by the formula [1] by using an ate hydride complex as a reducing agent. 2-Bromo-2,2-difluoroethanol thus produced can be used as the starting material to carry out the esterification step, the sulfination step and the oxidation step in this order, thereby producing a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid salt, wherein A represents a substituted or unsubstituted linear, branched or cyclic alkoxy group having 1 to 20 carbon atoms, a substituted or unsubstituted aryloxy group having 6 to 15 carbon atoms, a heteroaryloxy group having 4 to 15 carbon atoms, or a halogen atom.

摘要翻译： 公开了一种2-溴-2,2-二氟乙醇的制备方法，其包括使用氢化物​​络合物作为还原剂还原式[1]表示的溴二氟乙酸衍生物。 可以使用如此制备的2-溴-2,2-二氟乙醇作为起始原料，依次进行酯化步骤，硫化步骤和氧化步骤，由此制备2-烷基羰基氧基-1,1-二氟乙磺酸盐 其中A表示取代或未取代的具有1至20个碳原子的直链，支链或环状烷氧基，取代或未取代的碳原子数6〜15的芳氧基，碳原子数4〜15的杂芳氧基或卤素原子。

公开(公告)号：US08221336B2

公开(公告)日：2012-07-17

申请号：US12441638

申请日：2007-09-19

申请人： Masaki Fujiwara ,  Toshihiro Akiyama ,  Kenichi Hamanaka

发明人： Masaki Fujiwara ,  Toshihiro Akiyama ,  Kenichi Hamanaka

IPC分类号： A61B5/00 ,  A61B5/05 ,  B65D81/00

CPC分类号： G01N33/66 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150954 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15136 ,  A61B5/1519 ,  A61B5/157 ,  G01N27/3272

摘要： A blood sensor comprises a substrate, a spacer attached to the top of the substrate, a cover attached to the top of the spacer. A blood reservoir defined by a substrate hole formed in the substrate. A part of a spacer hole in the spacer and connected to the substrate hole, and a cover hole formed in the cover is connected to the spacer hole. A supply passage is defined by another part of the spacer hole that communicates with the blood reservoir portion, and detection electrodes are formed in the supply passage. The cover projects from the supply passage toward the inside of the blood reservoir portion farther than the substrate and the spacer.

摘要翻译： 血液传感器包括衬底，附着到衬底的顶部的间隔件，附接到间隔件的顶部的盖。 由在衬底中形成的衬底孔限定的血液储存器。 隔离件中的间隔孔的一部分连接到基板孔，并且形成在盖中的盖孔连接到间隔孔。 供给通道由与储血部连通的间隔孔的另一部分限定，检测电极形成在供给通道中。 所述盖从所述供给路径朝向所述血液存储部的内侧突出为比所述基板和所述间隔物更远。

公开(公告)号：US08110711B2

公开(公告)日：2012-02-07

申请号：US12678223

申请日：2008-09-05

申请人： Jonathan Joachim Jodry ,  Masashi Nagamori ,  Yuji Hagiwara ,  Masaki Fujiwara ,  Satoru Narizuka

发明人： Jonathan Joachim Jodry ,  Masashi Nagamori ,  Yuji Hagiwara ,  Masaki Fujiwara ,  Satoru Narizuka

IPC分类号： C07C29/143 ,  C07C67/16 ,  C07C309/08 ,  C07C309/10

CPC分类号： C07C309/17 ,  C07C29/147 ,  C07C67/08 ,  C07C67/14 ,  C07C303/32 ,  C07C309/08 ,  C07C309/12 ,  C07C313/04 ,  C07C381/12 ,  C07C2602/42 ,  C07C2603/74 ,  G03F7/0045 ,  G03F7/0046 ,  C07C31/34 ,  C07C69/653 ,  C07C69/63 ,  C07C69/753

摘要： Disclosed is a process for producing 2-bromo-2,2-difluoroethanol, which comprises reducing a bromodifluoroacetic acid derivative represented by the formula [1] by using an ate hydride complex as a reducing agent. 2-Bromo-2,2-difluoroethanol thus produced can be used as the starting material to carry out the esterification step, the sulfination step and the oxidation step in this order, thereby producing a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid salt, wherein A represents a substituted or unsubstituted linear, branched or cyclic alkoxy group having 1 to 20 carbon atoms, a substituted or unsubstituted aryloxy group having 6 to 15 carbon atoms, a heteroaryloxy group having 4 to 15 carbon atoms, or a halogen atom.

摘要翻译： 公开了一种2-溴-2,2-二氟乙醇的制备方法，其包括使用氢化物​​络合物作为还原剂还原式[1]表示的溴二氟乙酸衍生物。 可以使用如此制备的2-溴-2,2-二氟乙醇作为起始原料，依次进行酯化步骤，硫化步骤和氧化步骤，由此制备2-烷基羰基氧基-1,1-二氟乙磺酸盐 其中A表示取代或未取代的具有1至20个碳原子的直链，支链或环状烷氧基，取代或未取代的碳原子数6〜15的芳氧基，碳原子数4〜15的杂芳氧基或卤素原子。

公开(公告)号：US20120010486A1

公开(公告)日：2012-01-12

申请号：US13258641

申请日：2010-03-17

申请人： Masaki Fujiwara

发明人： Masaki Fujiwara

IPC分类号： A61B5/157 ,  G01N27/403 ,  G01N27/416

CPC分类号： G01N27/307 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150183 ,  A61B5/150213 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/15113 ,  A61B5/15134 ,  A61B5/15138 ,  A61B5/15174 ,  A61B5/157 ,  G01N27/26 ,  G01N27/283 ,  G01N27/3272 ,  G01N27/4166 ,  G01N33/49 ,  G01N35/1016 ,  G01N2035/1062 ,  G01N2400/00

摘要： This sensor chip (11) comprises a substrate (15) in the form of a flat board, a sample inlet (20) that is provided in the thickness direction of the substrate (15) and into which flows the blood (3) used for measurement, a supply path (21) that communicates with this sample inlet (20), and detection electrodes (17, 18, 19) provided to this supply path (21), wherein the substrate (15) is provided with a surplus blood reservoir (25) that draws in surplus blood (3a) and holds this drawn surplus blood (3a).

摘要翻译： 该传感器芯片（11）包括平板形式的基板（15），在基板（15）的厚度方向上设置的样品入口（20），并且将用于 测量，与该样品入口（20）连通的供给路径（21）以及设置在该供给路径（21）上的检测电极（17,18,19），其中，所述基板（15）设置有多余的血液储存器 （25）抽取剩余血液（3a）并持有该抽取的剩余血液（3a）。