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公开(公告)号:US5292726A
公开(公告)日:1994-03-08
申请号:US885416
申请日:1992-05-19
申请人: Wallace T. Ashton , Conrad P. Dorn , William J. Greenlee , Malcolm MacCoss , Sander G. Mills , Mu T. Wu
发明人: Wallace T. Ashton , Conrad P. Dorn , William J. Greenlee , Malcolm MacCoss , Sander G. Mills , Mu T. Wu
IPC分类号: A01N43/60 , A01N47/16 , A01N47/38 , C07D241/04 , C07D295/215 , C07D403/06 , A61K31/675 , A61K31/495 , C07F9/6509
CPC分类号: C07D295/215 , A01N43/60 , A01N47/16 , A01N47/38 , C07D241/04 , C07D403/06
摘要: Diacylpiperazines of general structure ##STR1## are: angiotensin II (A-II) antagonists selective for the type 2 (AT.sub.2) subtype useful in the treatment of cerebrovascular, cognitive, and CNS disorders; tachykinin receptor antagonists useful in the treatment of inflammatory diseases and pain or migraine; and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
摘要翻译: 一般结构的二酰基哌嗪是一种对可用于治疗脑血管,认知和中枢神经系统疾病的2型(AT2)亚型选择性的血管紧张素II(A-II)拮抗剂; 用于治疗炎性疾病和疼痛或偏头痛的速激肽受体拮抗剂; 和钙通道阻滞剂可用于治疗心血管疾病如心绞痛,高血压或缺血。
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122.Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element 失效
标题翻译: 喹唑啉酮,三唑啉酮和包含取代的苄基元素的嘧啶酮血管紧张素II拮抗剂公开(公告)号:US5264439A
公开(公告)日:1993-11-23
申请号:US744138
申请日:1991-08-13
申请人: William J. Greenlee , David Hangauer , Arthur A. Patchett , Thomas F. Walsh , Kenneth J. Fitch , Daljit S. Dhanoa , Ralph A. Rivero
发明人: William J. Greenlee , David Hangauer , Arthur A. Patchett , Thomas F. Walsh , Kenneth J. Fitch , Daljit S. Dhanoa , Ralph A. Rivero
IPC分类号: C07D235/08 , C07D239/36 , C07D239/91 , C07D249/12 , C07D471/04 , A61K31/505 , C07D239/90
CPC分类号: C07D471/04 , C07D235/08 , C07D239/36 , C07D239/91 , C07D249/12
摘要: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##
摘要翻译: 通过亚甲基桥连接到式I的新的取代的苯基衍生物的取代的杂环可用作血管紧张素II拮抗剂。
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123.
公开(公告)号:US5250521A
公开(公告)日:1993-10-05
申请号:US794533
申请日:1991-11-25
申请人: Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Malcolm MacCoss , Arthur A. Patchett , Thomas F. Walsh
发明人: Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Malcolm MacCoss , Arthur A. Patchett , Thomas F. Walsh
IPC分类号: C07D487/04 , A61K31/505 , A61K31/535 , A61K31/54
CPC分类号: C07D487/04
摘要: Novel substituted pyrazolopyrimidines of formula (I) which are useful as angiotensin II antagonists, are disclosed. ##STR1##
摘要翻译: 公开了用作血管紧张素II拮抗剂的式(I)的新型取代吡唑并嘧啶。 (一)
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124.Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring 失效
标题翻译: 掺入取代吡啶并咪唑环的血管紧张素II拮抗剂公开(公告)号:US5240938A
公开(公告)日:1993-08-31
申请号:US744557
申请日:1991-08-13
申请人: William J. Greenlee , Arthur A. Patchett , David Hangauer , Thomas F. Walsh , Kenneth J. Fitch , Ralph A. Rivero , Daljit S. Dhanoa
发明人: William J. Greenlee , Arthur A. Patchett , David Hangauer , Thomas F. Walsh , Kenneth J. Fitch , Ralph A. Rivero , Daljit S. Dhanoa
IPC分类号: A61K31/44 , C07D471/04 , C07D491/048
CPC分类号: C07D471/04 , A61K31/44
摘要: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##
摘要翻译: 通过亚甲基桥连接到式I的新的取代的苯基衍生物的取代的杂环可用作血管紧张素II拮抗剂。
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公开(公告)号:US5202328A
公开(公告)日:1993-04-13
申请号:US665517
申请日:1991-03-06
IPC分类号: A61K31/505 , A61P9/00 , A61P9/12 , A61P27/02 , A61P43/00 , C07D473/02 , C07D473/26 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07F9/6561
CPC分类号: C07D487/04 , C07D473/02 , C07D473/26 , C07D491/04 , C07D495/04 , C07D513/04 , C07F9/6561
摘要: Novel substituted fused pyrimidinones of formula (I), which are useful as angiotensin II antagonists, are disclosed. ##STR1##
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126.Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole 失效
标题翻译: 加入取代的1,3-苯并间二氧杂环戊烯或1,3-苯并二硫杂的血管紧张素II拮抗剂公开(公告)号:US5187159A
公开(公告)日:1993-02-16
申请号:US773070
申请日:1991-10-07
IPC分类号: A61K31/415 , A61K31/4184 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/475 , A61K31/496 , A61K31/52 , A61P9/00 , A61P9/12 , A61P27/02 , A61P43/00 , C07D235/06 , C07D235/08 , C07D235/26 , C07D235/28 , C07D405/06 , C07D409/06 , C07D411/06 , C07D471/04 , C07D473/00
CPC分类号: C07D405/06 , C07D471/04
摘要: 1,3-Benzodioxoles and 1,3-benzodithioles substituted with a 6-fused imidazole of Formula I which are useful as angiotensin II antagonists. ##STR1##
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127.Angiotensin II antagonists incorporating a substituted indole or dihydroindole 失效
标题翻译: ANGIOTENSIN II ANTAGONISTS INCORPORATING替代的吲哚或二氢吲哚公开(公告)号:US5175164A
公开(公告)日:1992-12-29
申请号:US710413
申请日:1991-06-05
IPC分类号: A61K31/41 , A61K31/505 , A61P9/12 , A61P27/02 , A61P43/00 , C07D401/14 , C07D403/06 , C07D403/14 , C07D471/04 , C07F9/6558
CPC分类号: C07D403/06 , C07D403/14 , C07D471/04
摘要: Substituted heterocycles attached through a methylene bridge to novel substituted indole or dihydroindole derivative of the Formula I are useful as angiotensin II antagonists. ##STR1##
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128.Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin II antagonsists 失效
标题翻译: 取代的IMIDAZO-FUSED 5结构环杂交体及其作为ANGIOTENSIN II拮抗剂的使用公开(公告)号:US5164407A
公开(公告)日:1992-11-17
申请号:US516502
申请日:1990-04-25
申请人: William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
发明人: William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
IPC分类号: A61K31/415 , A61K31/42 , A61K31/425 , A61P9/08 , A61P9/10 , A61P9/12 , A61P27/02 , A61P43/00 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D521/00 , C07F9/6561
CPC分类号: C07D487/04 , C07D491/04 , C07D495/04
摘要: There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula: ##STR1##
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129.
公开(公告)号:US5100897A
公开(公告)日:1992-03-31
申请号:US550951
申请日:1990-07-16
申请人: Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Arthur A. Patchett , Thomas F. Walsh
发明人: Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Arthur A. Patchett , Thomas F. Walsh
IPC分类号: A61K31/505 , A61P9/12 , A61P27/02 , C07D239/36 , C07D239/42 , C07D239/52 , C07D403/10 , C07D403/12 , C07F9/46
CPC分类号: C07D239/36 , C07D239/52 , C07D403/10
摘要: Novel substituted pyrimidinones of formula (I) which are useful as angiotensin II antagonists, are disclosed. ##STR1##
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130.
公开(公告)号:US5037807A
公开(公告)日:1991-08-06
申请号:US320681
申请日:1989-03-08
IPC分类号: C07K5/02
CPC分类号: C07K5/0207
摘要: Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.
摘要翻译: 其包含新型元件的肽,其包含基于底物类比替代肾素抑制肽中的Phe(8)-His(9)序列的新元件,其抑制肾素的底物切割作用并具有改善的生物利用度; 含有这些肾素抑制肽的组合物,任选与其它抗高血压药物组合; 以及在使用新型肽的这些问题中治疗高血压或充血性心力衰竭或建立肾素作为致病因素的方法。
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