公开(公告)号：US4585788A

公开(公告)日：1986-04-29

申请号：US459774

申请日：1974-04-10

申请人： Grover C. Helsley ,  Arthur R. McFadden ,  David Hoffman

发明人： Grover C. Helsley ,  Arthur R. McFadden ,  David Hoffman

IPC分类号： C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  A61K31/335

CPC分类号： C07D313/12 ,  C07C59/70 ,  C07C65/24

摘要： 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula ##STR1## are prepared by multi-step sequences. X is C.dbd.O, CHCl, CHBr, CH.sub.2 or CHOR.sup.4 ; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR.sup.5, CH.sub.2 OR.sup.5, CONR.sub.2.sup.5 or CONHOR.sup.5 ; and R.sup.1 -R.sup.5 are hydrogen or alkyl of 1 to 4 carbon atoms.These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.

摘要翻译： 6,11-二氢二苯并[b，e]氧杂七环素 - 乙酸和具有通式的衍生物通过多步序列制备。 X是C = O，CHCl，CHBr，CH 2或CHOR 4; Y是1至4个碳原子的烷基或烷氧基，卤素或三氟甲基; n为0,1,2或3; Z是COOR5，CH2OR5，CONR25或CONHOR5; 并且R 1 -R 5是氢或1至4个碳原子的烷基。 这些化合物及其生理上可耐受的盐可用作抗炎和止痛剂。