-
公开(公告)号：US09687163B2
公开(公告)日：2017-06-27
申请号：US14067888
申请日：2013-10-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Yu Han , Wentai Liu , Yue-Loong Hsin
IPC: A61B5/04 , A61B5/0476 , A61B5/048 , A61B5/00
CPC classification number: A61B5/04014 , A61B5/0476 , A61B5/048 , A61B5/4064 , A61B5/4094 , A61B5/7257
Abstract: Epileptogenic source localization methods and systems based on ECoG signals are provided for obtaining spatial and temporal relationships among epileptogenic zones. Seizure detection is based on an Independent Component Analysis (ICA) and temporal and spatial relationships among the detected epileptogenic zones are based on a steepest descent-based source localization method. Embodiments of the invention facilitate the epileptiform activity investigation and seizure dynamics study and further benefit the neurophysiology community in the surgical decision making of neurosurgeons.
-
公开(公告)号：US09682073B2
公开(公告)日：2017-06-20
申请号：US15075375
申请日：2016-03-21
Applicant: Gilrose Pharmaceuticals, LLC
Inventor： Bruce Roseman , Gilla Kaplan
IPC: A61K31/454 , A61K31/4458 , A61K45/06 , A61B5/055 , A61B5/00
CPC classification number: A61K31/4458 , A61B5/055 , A61B5/4064 , A61B5/4803 , A61K31/454 , A61K45/06 , A61K2300/00
Abstract: A methylphenidate, particularly including dextro-threo-methylphenidate, is administered to a subject to treat a speech, gait or limb impairment secondary to a genetically acquired pre-frontal cortex processing disease or disorder, particularly including multiple sclerosis, cerebral palsy, Angelman syndrome, Rett syndrome and Fragile-X syndrome.
-
公开(公告)号：US20170169191A1
公开(公告)日：2017-06-15
申请号：US15400462
申请日：2017-01-06
Applicant: Elwha LLC
Inventor： Jeffrey A. Bowers , Paul Duesterhoft , Daniel Hawkins , Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr.
CPC classification number: G06F19/3481 , A61B3/113 , A61B5/0022 , A61B5/024 , A61B5/0476 , A61B5/117 , A61B5/16 , A61B5/4064 , A61B5/4082 , A61B5/4088 , A61B5/4803 , A61B5/4833 , G06F19/325 , G10L25/66 , G10L25/78 , G16H10/20 , G16H10/60 , G16H15/00 , G16H20/30 , G16H20/70 , G16H40/63 , G16H40/67 , G16H50/70 , G16H80/00 , H04L67/18
Abstract: Methods and systems for monitoring compliance of a patient with a prescribed treatment regimen are described. Patient activity is detected unobtrusively with an activity sensor at the patient location, and activity data is transmitted to a monitoring location. Patient speech detected during use of a communication system such as a mobile telephone by the patient may also be used as an activity signal. Patient activity and/or speech is processed at the patient location or monitoring location to identify activity parameters or patterns that indicate whether the patient has complied with the prescribed treatment regimen. The activity sensor and other components at the patient location may be incorporated into, or associated with, a cell phone, computing system, game system, or vehicle system, for example. The system may provide a report to an interested party, for example a medical care provider or insurance company, regarding patient compliance with the prescribed treatment regimen.
-
公开(公告)号：US20170150907A1
公开(公告)日：2017-06-01
申请号：US15175905
申请日：2016-06-07
Applicant: Cerebral Assessment Systems, LLC
Inventor： Charles Joseph Duffy
CPC classification number: A61B5/1125 , A61B3/0091 , A61B5/1124 , A61B5/12 , A61B5/16 , A61B5/168 , A61B5/4064 , A61B5/4082 , A61B5/4088 , A61B5/411 , A61B5/7435 , A61B5/7475 , G09B7/00 , G09B7/02 , G09B7/06
Abstract: The disclosure provides a method for performing automated visual motor response assessment by receiving motor response input responsive to presenting visual stimulation, the method including: presenting a scene to a subject on a display; modulating contrast of a predetermined section of the scene; moving the predetermined section relative to the scene; providing a manual input device for tracking movement of the predetermined section; receiving tracked movement data from the manual input device; measuring a kinematic parameter of the tracked movement data; quantitatively refining the tracked movement; determining a relationship between at least one of the scene and quantitatively refined tracked movement; adjusting modulated contrast relative to the quantitatively refined tracked movement; and calculating a critical threshold parameter in relation to a subject.
-
135.发明申请
公开(公告)号：US20170135583A1
公开(公告)日：2017-05-18
申请号：US15348397
申请日：2016-11-10
Applicant: The Johns Hopkins University
Inventor： David W. Blodgett , Mark A. Chevillet , Michael P. McLoughlin
CPC classification number: A61B5/0082 , A61B5/0042 , A61B5/0066 , A61B5/0073 , A61B5/14553 , A61B5/4064 , A61B2576/026 , G01B9/02011 , G01B9/0203 , G01B9/02091 , G02B5/3025 , G02B27/10 , G02F2/00 , G03H1/0005 , G03H1/0402 , G03H1/0443 , G03H1/0465 , G03H1/265 , G03H2001/0033 , G03H2001/0436 , G03H2001/0452 , G03H2001/0469 , G03H2222/20 , G03H2225/36 , G03H2226/02 , G03H2226/13
Abstract: A neural imaging system may include an imaging array, an image data processor operably coupled to the imaging array to process image data received from the imaging array, and a beam angle separator disposed between the imaging array and an object being imaged. The beam angle separator may be configured to separate an object beam reflected from the object being imaged into a plurality of reference beams each having different angular separation with respect to the object beam. The image data processor may be configured to generate image data of the object for each one of the reference beams to correspond to a respective different depth within the object.
-
公开(公告)号：US20170128738A1
公开(公告)日：2017-05-11
申请号：US15343755
申请日：2016-11-04
Applicant: Weinberg Medical Physics, Inc.
Inventor： Irving N. WEINBERG
CPC classification number: A61N2/006 , A61B5/0035 , A61B5/0515 , A61B5/055 , A61B5/4064 , A61B18/04 , A61B2018/00577 , A61B2090/365 , A61B2090/374 , A61B2576/00 , A61N1/3605 , A61N1/40 , A61N5/0622
Abstract: An apparatus and method for stimulating one or more cells within a subject's brain by one or more magnetizable particles under the influence of at least one coil, wherein the coil is located outside the body of the subject, and is used to visualize and move the one or more magnetizable particles and to visualize the subject's underlying anatomy containing the one or more cells.
-
公开(公告)号：US09636239B2
公开(公告)日：2017-05-02
申请号：US12860500
申请日：2010-08-20
Applicant: Dominique M. Durand , Brian Wodlinger
Inventor： Dominique M. Durand , Brian Wodlinger
CPC classification number: A61B5/04001 , A61B5/4041 , A61B5/4064 , A61F2/72 , A61N1/0551 , A61N1/36003 , G06F17/5009
Abstract: Systems and methods are provided for controlling an entity in response to activity in a peripheral nerve comprising a plurality of fascicles. A multicontact electrode assembly is configured to record activity from the peripheral nerve. A processing component includes a sensor mapping component configured to quantify activity associated with a proper subset of the plurality of fascicles, an evaluation component configured to determine an adjustment of the status of the controlled entity from the quantified activity of the proper subset of the plurality of fascicles, and a controller configured to provide a control signal, representing the adjustment of the status of the controlled entity, to the controlled entity.
-
公开(公告)号：US20170113046A1
公开(公告)日：2017-04-27
申请号：US15317319
申请日：2015-06-09
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Itzhak FRIED , Dejan MARKOVIC , Nanthia SUTHANA
CPC classification number: A61N1/36082 , A61B5/0476 , A61B5/0478 , A61B5/055 , A61B5/4064 , A61B5/4094 , A61B5/4836 , A61B5/6868 , A61N1/025 , A61N1/0531 , A61N1/0534 , A61N1/36092 , A61N1/36125 , A61N1/36139 , A61N1/37229 , G06F19/3481 , G16H50/50
Abstract: Systems and methods for restoring cognitive function are disclosed. In some implementations, a method includes, at a computing device, separately stimulating one or more of lateral and medial entorhinal afferents and other structures connecting to a hippocampus of an animal subject in accordance with a plurality of predefined stimulation patterns, thereby attempting to restore object-specific memories and location-specific memories; collecting a plurality of one or more of macro- and micro-recordings of the stimulation of hippocampalentorhinal cortical (HEC) system; and refining the computational model for restoring individual memories in accordance with a portion of the plurality of one or more of macro- and micro-recordings.
-
139.发明申请
公开(公告)号：US20170105631A1
公开(公告)日：2017-04-20
申请号：US15296150
申请日：2016-10-18
Applicant: COVIDIEN LP
Inventor： Paul Stanley Addison , James N. Watson , Dean Montgomery
IPC: A61B5/0205 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/021 , A61B5/026
CPC classification number: A61B5/0205 , A61B5/0059 , A61B5/02028 , A61B5/021 , A61B5/026 , A61B5/0261 , A61B5/031 , A61B5/14546 , A61B5/14553 , A61B5/4064 , A61B5/7246 , A61B5/742 , A61B5/7425 , A61B5/743 , G16H40/63 , G16H50/20 , G16H50/30
Abstract: A method for monitoring autoregulation includes, using a processor, using a processor to execute one or more routines on a memory. The one or more routines include receiving one or more physiological signals from a patient, determining a correlation-based measure indicative of the patient's autoregulation based on the one or more physiological signals, and generating an autoregulation profile of the patient based on autoregulation index values of the correlation-based measure. The autoregulation profile includes the autoregulation index values sorted into bins corresponding to different blood pressure ranges. The one or more routines also include designating a blood pressure range encompassing one or more of the bins as a blood pressure safe zone indicative of intact regulation and providing a signal to a display to display the autoregulation profile and a first indicator of the blood pressure safe zone.
-
140.发明授权
公开(公告)号：US09622671B2
公开(公告)日：2017-04-18
申请号：US13843023
申请日：2013-03-15
Inventor： Douglas Weber , Robert Gaunt , Timothy Bruns
CPC classification number: A61N1/36139 , A61B5/04001 , A61B5/1107 , A61B5/112 , A61B5/202 , A61B5/205 , A61B5/4064 , A61B5/4255 , A61B5/4393 , A61B5/4519 , A61B5/4824 , A61B5/4836 , A61B5/7246 , A61B2560/0223 , A61B2562/0209 , A61B2562/028 , A61B2562/04 , A61M5/1723 , A61N1/025 , A61N1/0551 , A61N1/36003 , A61N1/36007 , A61N1/3606 , A61N1/36071 , A61N1/36082 , A61N1/36107
Abstract: Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for monitoring or controlling bladder function in a patient.
