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公开(公告)号:US20040242568A1
公开(公告)日:2004-12-02
申请号:US10809636
申请日:2004-03-24
申请人: Syrrx, Inc.
发明人: Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号: A61K031/549 , A61K031/513 , C07D417/02
CPC分类号: C07D471/04 , C07D401/04 , C07D403/04 , C07D473/18 , C07D487/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising the formula: 1 wherein Q is selected from the group consisting of CO, SO, SO2, or CnullNR9; and R1, R2, R3 and R4 are as defined herein.
摘要翻译: 提供化合物,药物,试剂盒和方法用于DPP-IV和其它S9蛋白酶,其包含下式的化合物:其中Q选自CO,SO,SO 2或C = NR 9; 并且R 1,R 2,R 3和R 4如本文所定义。
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公开(公告)号:US20050153966A1
公开(公告)日:2005-07-14
申请号:US11015348
申请日:2004-12-17
IPC分类号: A61K31/519 , A61K31/53 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/02 , C07D513/04
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D471/04 , C07D513/04
摘要: The invention relates to compounds of the following formula that may be used to inhibits kinases, as well as compositions of matter and kits comprising these compounds. The present invention also relates to methods for inhibiting kinases, as well as treatment methods using compounds according to the present invention.
摘要翻译: 本发明涉及可用于抑制激酶的下式的化合物,以及包含这些化合物的物质组合物和试剂盒。 本发明还涉及抑制激酶的方法,以及使用根据本发明的化合物的治疗方法。
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13.
公开(公告)号:US06916372B2
公开(公告)日:2005-07-12
申请号:US10060418
申请日:2002-01-29
申请人: Peter R. David
发明人: Peter R. David
CPC分类号: C30B7/00 , B01J2219/00274 , B33Y80/00 , C30B29/58 , G01N25/147 , Y10T117/1004
摘要: A microfluidic device comprising: a substrate shaped so as to provide the device with an axis of rotation about which the device may be rotated; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume that is in fluid communication with the first submicrovolume when the device is rotated, the plurality of microvolumes being arranged in the device such that fluid in the first submicrovolumes of multiple of the microvolumes is transported to the second submicrovolumes of the associated microvolumes when the device is rotated about the rotational axis.
摘要翻译: 一种微流体装置,包括:基板,其被成形为为所述装置提供所述装置可旋转的旋转轴线; 以及由所述衬底至少部分地限定的多个微卷,每个微体积包括第一亚微体积和第二亚微体积,所述第一亚微体积和所述第二亚微体积在所述装置旋转时与所述第一亚微体积流体连通,所述多个微量体积被布置在所述装置中, 当装置围绕旋转轴线旋转时,多个微体积的第一微量体积被传送到相关联的微卷的第二亚微体积。
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公开(公告)号:US20050137234A1
公开(公告)日:2005-06-23
申请号:US11013234
申请日:2004-12-14
申请人: Jerome Bressi , Anthony Gangloff , Andrew Jennings
发明人: Jerome Bressi , Anthony Gangloff , Andrew Jennings
IPC分类号: A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/4155 , A61K31/416 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/443 , A61K31/4436 , A61K31/4525 , A61K31/454 , A61K31/4709 , A61K31/497 , C07D235/18 , C07D307/85 , C07D333/70 , C07D401/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , A61K31/4439 , A61K31/343 , A61K31/405 , A61K31/427
CPC分类号: C07D401/04 , C07D235/18 , C07D307/85 , C07D333/70 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: Histone deacetylase inhibitors and uses thereof are provided that have the general formula: Z-L-M wherein Z, L and M are as defined herein.
摘要翻译: 提供组蛋白脱乙酰酶抑制剂及其用途,其具有以下通式:<?in-line-formula description =“In-line Formulas”end =“lead”?> ZLM <?in-line-formula description =“In-line 式“end =”tail“?>其中Z,L和M如本文所定义。
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公开(公告)号:US20050070531A1
公开(公告)日:2005-03-31
申请号:US10918186
申请日:2004-08-12
申请人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号: A61K9/08 , A61K9/20 , A61K31/506 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D239/02 , C07D239/36 , C07D239/46 , C07D239/52 , C07D285/16 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04 , A61K31/549 , A61K31/513
CPC分类号: C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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公开(公告)号:US20050065148A1
公开(公告)日:2005-03-24
申请号:US10918318
申请日:2004-08-12
申请人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号: A61K9/08 , A61K9/20 , A61K31/506 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D239/02 , C07D239/36 , C07D239/46 , C07D239/52 , C07D285/16 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04 , C07D273/04 , A61K31/539
CPC分类号: C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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公开(公告)号:US20050004117A1
公开(公告)日:2005-01-06
申请号:US10809635
申请日:2004-03-24
申请人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号: A61K20060101 , A61K6/00 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/5395 , A61K31/549 , C07D239/95 , C07D285/16 , C07D401/04 , C07D403/04 , C07D417/02 , C07D471/04 , C07D473/18 , C07D487/04
CPC分类号: C07D471/04 , C07D401/04 , C07D403/04 , C07D473/18 , C07D487/04
摘要: Compounds, pharmaceuticals, kits, and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C═NR9; and R1, R2, R3 and R4 are as defined herein.
摘要翻译: 提供化合物,药物,试剂盒和方法用于DPP-IV和其它S9蛋白酶,其包含下式的化合物:其中Q选自CO,SO,SO 2或C = NR 9; 并且R 1,R 2,R 3和R 4如本文所定义。
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公开(公告)号:US06994749B2
公开(公告)日:2006-02-07
申请号:US10061080
申请日:2002-01-29
申请人: Peter R. David
发明人: Peter R. David
IPC分类号: C30B7/14
CPC分类号: C30B7/00 , B01J2219/00274 , B33Y80/00 , C30B29/58 , G01N25/147 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要: A microfluidic device is provided that comprises: a substrate; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume in fluid communication with the first submicrovolume when the device is rotated about a first rotational axis; wherein rotation of the device about the first rotational axis causes a fixed volume to be transported to each of the second submicrovolumes.
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公开(公告)号:US20050137232A1
公开(公告)日:2005-06-23
申请号:US10803580
申请日:2004-03-17
申请人: Jerome Bressi , Jason Brown , Sheldon Cao , Anthony Gangloff , Andrew Jennings , Jeffrey Stafford , Phong Vu , Xiao-Yi Xiao
发明人: Jerome Bressi , Jason Brown , Sheldon Cao , Anthony Gangloff , Andrew Jennings , Jeffrey Stafford , Phong Vu , Xiao-Yi Xiao
IPC分类号: A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/535 , C07D235/18 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号: C07D235/18 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/10
摘要: Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.
摘要翻译: 可用于抑制组氨酸脱乙酰酶的化合物,其具有式<?in-line-formula description =“In-line Formulas”end =“lead”?> ZQLM或ZLM <?in-line-formula description =“In-line 式“end =”tail“?>其中M是能够与脱乙酰酶催化部位和/或金属离子络合的取代基; L是在M取代基和化合物的其余部分之间分离0-10个原子之间的取代基; Z和Q如本文所定义。
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公开(公告)号:US20050075330A1
公开(公告)日:2005-04-07
申请号:US10918327
申请日:2004-08-12
申请人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号: A61K9/08 , A61K9/20 , A61K31/506 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D239/02 , C07D239/36 , C07D239/46 , C07D239/52 , C07D285/16 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04 , A61K31/513 , A61K31/549 , C07D43/04
CPC分类号: C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
摘要翻译: 提供化合物,药物,试剂盒和方法用于包含式I的DPP-IV抑制剂:其中取代基如本文所述。
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