公开(公告)号：US06649763B1

公开(公告)日：2003-11-18

申请号：US09979644

申请日：2001-11-16

Applicant: Sung June Yoon ,  Yong Ho Chung ,  Chi Woo Lee ,  Jin Soo Lee ,  Nam Doo Kim ,  Yoon Ho Jin ,  Wan Jin Song ,  Ik Hoe Kim ,  Wang Yong Yang ,  Dong Rack Choi ,  Jung Han Shin

Inventor： Sung June Yoon ,  Yong Ho Chung ,  Chi Woo Lee ,  Jin Soo Lee ,  Nam Doo Kim ,  Yoon Ho Jin ,  Wan Jin Song ,  Ik Hoe Kim ,  Wang Yong Yang ,  Dong Rack Choi ,  Jung Han Shin

IPC: C07D215233

CPC classification number: C07D401/04 ,  C07D471/04 ,  C07D487/10

Abstract: The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active quinoline carboxylic acid derivatives containing 4-aminomethyl-4-methyl-3-(Z)-alkoxyirninopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.

Abstract translation: 本发明涉及光学活性喹啉羧酸衍生物，其药学上可接受的盐，其溶剂合物及其制备方法。 更具体地说，本发明涉及含有4-氨基甲基-4-甲基-3-（Z） - 烷氧基亚氨基吡咯烷基取代基的喹啉羧酸衍生物，其在喹诺酮核的7-位引起光学活性。 由于本发明的化合物对其对映异构体，它们的外消旋体和常规抗菌剂具有优异的抗菌活性和药代动力学特性，几乎没有光毒性，所以本发明的化合物可用于抗菌剂。

公开(公告)号：US20080029479A1

公开(公告)日：2008-02-07

申请号：US11782949

申请日：2007-07-25

Applicant: Bong Hwan Kim ,  Bum Jin Park ,  Jong Bok Kim ,  Chi Woo Lee

Inventor： Bong Hwan Kim ,  Bum Jin Park ,  Jong Bok Kim ,  Chi Woo Lee

IPC: B44C1/22

CPC classification number: G01R3/00 ,  G01R1/06727

Abstract: A method for manufacturing a probe structure is wherein a disclosed. In accordance with method, two semiconductor substrates having different crystal directions are bonded and selectively etched utilizing an etch selectivity due to the different crystal directions to form a probe tip region and a probe beam region. A cantilever structure for a probe card is formed by filling the probe tip region and the probe beam region with a conductive material.

Abstract translation: 一种探针结构的制造方法，其中公开的。 根据方法，由于不同的晶体方向，使用具有不同晶体方向的两个半导体衬底被结合并选择性地蚀刻，以形成探针尖端区域和探针光束区域。 通过用导电材料填充探针尖端区域和探针束区域来形成用于探针卡的悬臂结构。

公开(公告)号：US5496947A

公开(公告)日：1996-03-05

申请号：US193475

申请日：1994-02-08

Applicant: Sung-June Yoon ,  Young-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Dong-Rack Choi ,  Nam-Doo Kim

Inventor： Sung-June Yoon ,  Young-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Dong-Rack Choi ,  Nam-Doo Kim

IPC: A61K31/47 ,  A61K31/495 ,  A61P31/04 ,  C07D401/04 ,  C07D401/14 ,  C07D471/04

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D471/04

Abstract: The present invention relates to the novel quinolone carboxylic acid derivatives of the following formula (I) and their pharmaceutically acceptable salts and their hydrates. ##STR1## wherein X is a hydrocarbon, fluorocarbon or nitrogen atom,Y is a hydrogen or methyl group,R.sup.1 is a hydrogen or alkyl group having 1 to 5 carbon atom,R.sup.2 is ##STR2## wherein A and B is a fluorocarbon or nitrogen atom, provided that, if A.dbd.CF, B.dbd.N and if A.dbd.N, B.dbd.CF) andR.sup.3 is ##STR3## (wherein R.sup.4 is an amino group which makes a racemate or (S)-enantiomer) or ##STR4## (wherein R.sup.5, R.sup.6 and R.sup.7 are respectively hydrogen or alkyl group having 1 to 3 carbon atom.).The compounds according to the present invention are used as antibacterial agents.

Abstract translation: 本发明涉及下式（I）的新型喹诺酮羧酸衍生物及其药学上可接受的盐及其水合物。 （I）其中X是烃，碳氟化合物或氮原子，Y是氢或甲基，R 1是氢或具有1至5个碳原子的烷基，R 2是其中A和B是 碳原子或氮原子，条件是如果A = CF，B = N，如果A = N，B = CF），并且R 3是（其中R 4是制备外消旋体或（S） - 对映异构体的氨基） 或者其中R5，R6和R7分别是氢或具有1-3个碳原子的烷基。 根据本发明的化合物用作抗菌剂。