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12 条记录 (耗时 0.015 秒)

    Method of conducting searches on the internet to obtain selected information on local entities and provide for searching the data in a way that lists local businesses at the top of the results
    11.
    发明授权
    Method of conducting searches on the internet to obtain selected information on local entities and provide for searching the data in a way that lists local businesses at the top of the results 失效
    在互联网上进行搜索以获取关于当地实体的选定信息的方法，并以列出结果顶部的本地企业的方式搜索数据

    公开(公告)号：US08015172B1

    公开(公告)日：2011-09-06

    申请号：US12459517

    申请日：2009-07-03

    申请人： Mark D Cave ,  David Mercer

    发明人： Mark D Cave ,  David Mercer

    IPC分类号： G06F17/30

    CPC分类号： G06F17/3087

    摘要： The invention utilizes local search engines to view a display of local business listings in order of relevance to the user. Relevance to the user depends on a variety of factors whose importance varies by user and business—these factors include distance from user-defined starting location, business size, whether or not the business is local, content provided with listing, and relevance based on user-defined search terms. The system collects and parses business information from Web pages and other sources, stores the information in a format that facilitates searches, provides a simple way for users to initiate searches, analyzes all the factors mentioned above each time a search is performed, retrieves listings in order of factor importance, and displays results to the user in order and formatted to make further inspection and use of the results easy for the user.

    摘要翻译： 本发明利用本地搜索引擎以与用户相关的顺序查看本地商家列表的显示。 用户的相关性取决于用户和业务的重要性各不相同的因素 - 这些因素包括与用户定义的起始位置的距离，业务规模，业务是否为本地，与列表提供的内容以及基于用户的相关性 定义的搜索词。 系统从网页和其他来源收集和分析业务信息，以有助于搜索的格式存储信息，为用户提供搜索提供了一种简单的方式，每次执行搜索时分析上述所有因素，检索列表 重要因素的顺序，并按顺序向用户显示结果并进行格式化，以便对用户进行进一步的检查和使用。

    Animal model having a chimeric human liver
    12.
    发明申请
    Animal model having a chimeric human liver 有权
    具有嵌合人肝脏的动物模型

    公开(公告)号：US20070107069A1

    公开(公告)日：2007-05-10

    申请号：US11517941

    申请日：2006-09-07

    申请人： Norman Kneteman ,  D. Tyrrell ,  David Mercer

    发明人： Norman Kneteman ,  D. Tyrrell ,  David Mercer

    IPC分类号： A01K67/027

    CPC分类号： C12N15/8509 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0337 ,  C07K14/765 ,  C12N9/6424 ,  C12N15/63

    摘要： The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.

    摘要翻译： 本发明的特征在于非人动物模型，其易受人类肝营养性病原体特别是人丙型肝炎病毒（HCV）的感染。 该模型基于具有人 - 小鼠嵌合肝的非人免疫受损转基因动物，其中转基因提供在肝脏中表达尿激酶型纤溶酶原激活物。 本发明还涉及用于鉴定候选治疗剂的方法，例如具有抗HCV感染的抗病毒活性的试剂。 本发明的动物也可用于评估各种药物的毒性，以及药物在降低血脂中的活性。