公开(公告)号：US4367338A

公开(公告)日：1983-01-04

申请号：US858554

申请日：1977-12-08

Applicant: David R. Adams ,  Alexander C. Goudie

Inventor： David R. Adams ,  Alexander C. Goudie

IPC: A61K31/41 ,  C07C57/03 ,  C07D249/12

CPC classification number: C07D249/12 ,  C07C309/00 ,  C07C57/03

Abstract: Compounds of formula (I) ##STR1## wherein: n is 1 to 5Y is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--;R.sub.1 is hydrogen or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1-12 carbon atoms;R.sub.2 is hydrogen, C.sub.1-4 alkyl, or phenyl;R.sub.3 is hydroxy or protected hydroxy;R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl --C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl moieties or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or nitro groups;R.sub.5 is hydrogen, C.sub.1-6 alkyl, C.sub.5-8 cycloalkyl, phenyl, phenyl-C.sub.1-6 alkyl or phenyl C.sub.3-6 cycloalkyl, any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups;orR.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and salts thereof are useful for their prostaglandin-like activity.

Abstract translation: 式（I）化合物其中：n为1至5，Y为-CH 2 -CH 2或-CH = CH-; R 1是氢或CO 2 R 1表示其中R 1部分含有1-12个碳原子的酯基; R2是氢，C1-4烷基或苯基; R3是羟基或被保护的羟基; R4是氢，C1-9烷基，C3-8环烷基，C3-8环烷基-C 1-6烷基，苯基，苯基-C 1-6烷基，萘基，萘基C 1-6烷基，任何苯基部分或萘基部​​分可以 被一个或多个卤素，三氟甲基，C 1-6烷基，羟基，C 1-6烷氧基，苯基C 1-6烷氧基或硝基取代; R 5是氢，C 1-6烷基，C 5-8环烷基，苯基，苯基-C 1-6烷基或苯基C 3-6环烷基，其中任何一个苯基部分可以被一个或多个卤素，三氟甲基，C 1-6烷基， C 1-6烷氧基或硝基; 或与其连接的碳原子取代的R 2和R 4表示C 5-8环烷基; 及其盐可用于其前列腺素样活性。