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公开(公告)号:US20090062147A1
公开(公告)日:2009-03-05
申请号:US11906939
申请日:2007-10-04
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
IPC分类号: C40B50/06
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译: 本发明提供合成包含编码寡核苷酸标签的分子文库的方法。
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公开(公告)号:US20050158765A1
公开(公告)日:2005-07-21
申请号:US11015458
申请日:2004-12-17
申请人: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
发明人: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译: 本发明提供合成包含编码寡核苷酸标签的分子文库的方法。
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13.METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS 有权
标题翻译: 使用FUCOSE模拟抑制蛋白质纤维蛋白的方法公开(公告)号:US20130129784A1
公开(公告)日:2013-05-23
申请号:US13814083
申请日:2011-08-05
申请人: Peter Senter , Stephen Alley , Dennis Benjamin
发明人: Peter Senter , Stephen Alley , Dennis Benjamin
IPC分类号: A61K31/7004 , A61K31/7048 , A61K31/7024
CPC分类号: A61K31/7004 , A61K9/0053 , A61K31/7024 , A61K31/7042 , A61K31/7048 , A61K31/706 , A61K39/0011 , A61K45/06 , A61K2039/5152 , A61K2039/545 , C07K16/00 , C07K16/18 , C07K2317/41 , Y02A50/386 , Y02A50/388 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/484
摘要: The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.
摘要翻译: 本发明提供通过施用岩藻糖类似物在体内抑制蛋白质包括抗体的岩藻糖基化的方法和组合物。
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公开(公告)号:US20120294853A1
公开(公告)日:2012-11-22
申请号:US13530074
申请日:2012-06-21
申请人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans Peter Gerber , Leigh Francisco
发明人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans Peter Gerber , Leigh Francisco
IPC分类号: A61K39/395 , A61P35/02 , A61P35/00
CPC分类号: A61K47/6803 , A61K38/05 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/423
摘要: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
摘要翻译: 本发明尤其涉及CD19结合剂和使用这种CD19结合剂来治疗疾病的方法。
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公开(公告)号:US08242252B2
公开(公告)日:2012-08-14
申请号:US13109957
申请日:2011-05-17
申请人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans Peter Gerber , Leigh Francisco
发明人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans Peter Gerber , Leigh Francisco
IPC分类号: C07H21/04
CPC分类号: A61K47/6803 , A61K38/05 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/423
摘要: This invention relates to CD 19 binding agents and methods of using such CD 19 binding agents for treating disease.
摘要翻译: 本发明涉及CD19结合剂和使用这种CD19结合剂治疗疾病的方法。
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16.
公开(公告)号:US20100330107A1
公开(公告)日:2010-12-30
申请号:US12718902
申请日:2010-03-05
申请人: Jean Gudas , Aya Jakobovits , Zili An , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Dennis Benjamin , Ruth Moser , Peter Senter
发明人: Jean Gudas , Aya Jakobovits , Zili An , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Dennis Benjamin , Ruth Moser , Peter Senter
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00
CPC分类号: C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6863 , A61K2039/505 , C07K16/3046
摘要: Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译: 本文描述了结合24P4C12蛋白及其变体的抗体药物偶联物(ADC)。 24P4C12在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,本发明的ADC提供了用于治疗癌症的治疗组合物。
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17.
公开(公告)号:US20070224607A1
公开(公告)日:2007-09-27
申请号:US11584880
申请日:2006-10-23
申请人: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
发明人: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
CPC分类号: C12N15/1068 , C07H21/00
摘要: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译: 本发明提供了通过筛选包括编码寡核苷酸标签的分子文库来鉴定感兴趣的化合物的方法。
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18.Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis 失效
标题翻译: 用于鉴别,评估,预防和治疗子宫内膜异位症的成分,试剂盒和方法公开(公告)号:US20050130182A1
公开(公告)日:2005-06-16
申请号:US10887775
申请日:2004-07-09
申请人: Jeffrey Messer , Dennis Benjamin , James Vath , Eric Sigel
发明人: Jeffrey Messer , Dennis Benjamin , James Vath , Eric Sigel
IPC分类号: C07K14/47 , C07K14/575 , C07K14/75 , C12Q1/68 , G01N33/48 , G01N33/53 , G01N33/567 , G01N33/574 , G01N33/68
CPC分类号: G01N33/57442 , C07K14/472 , C07K14/57581 , C07K14/75 , G01N33/689 , G01N2500/00 , G01N2800/364
摘要: The invention relates to newly discovered marker polypeptides associated with endometriosis. Compositions, kits, and methods for detecting, characterizing, preventing, and treating endometriosis are provided.
摘要翻译: 本发明涉及与子宫内膜异位症相关的新发现的标记多肽。 提供了用于检测,表征,预防和治疗子宫内膜异位症的组合物,试剂盒和方法。
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19.
公开(公告)号:US08309093B2
公开(公告)日:2012-11-13
申请号:US12718902
申请日:2010-03-05
申请人: Jean Gudas , Aya Jakobovits , Zili An , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Dennis Benjamin , Ruth Moser , Peter Senter
发明人: Jean Gudas , Aya Jakobovits , Zili An , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Dennis Benjamin , Ruth Moser , Peter Senter
IPC分类号: A61K39/395
CPC分类号: C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6863 , A61K2039/505 , C07K16/3046
摘要: Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译: 本文描述了结合24P4C12蛋白及其变体的抗体药物偶联物(ADC)。 24P4C12在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号:US20110312088A1
公开(公告)日:2011-12-22
申请号:US13109957
申请日:2011-05-17
申请人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans Peter Gerber , Leigh Francisco
发明人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans Peter Gerber , Leigh Francisco
CPC分类号: A61K47/6803 , A61K38/05 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/423
摘要: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
摘要翻译: 本发明尤其涉及CD19结合剂和使用这种CD19结合剂来治疗疾病的方法。
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