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公开(公告)号:US20090326245A1
公开(公告)日:2009-12-31
申请号:US12428399
申请日:2009-04-22
申请人: Eric J. HAGEN , Kevin Halloran
发明人: Eric J. HAGEN , Kevin Halloran
IPC分类号: C07D209/52
CPC分类号: A61K31/403 , C07D209/52 , C07D209/94
摘要: The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph form C, where polymorph form A is more thermodynamically stable than the other forms, methods for preparing and using such polymorph forms and pharmaceutical compositions containing such polymorph forms.
摘要翻译: 本发明提供称为多晶型A,多晶型B和多晶型C的(+) - 1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷的酸加成盐的多晶型,其中多晶型 形式A比其他形式更热力学稳定,制备和使用这种多晶型形式的方法和含有这种多晶型形式的药物组合物。
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公开(公告)号:US20110275695A1
公开(公告)日:2011-11-10
申请号:US12997499
申请日:2009-06-11
CPC分类号: C07D337/14
摘要: The invention relates to crystalline forms of zotepine hydrochloride, including the crystalline hydrochloride salt of zotepine and two cocrystals of zotepine hydrochloride with benzoic acid. The preparation and characterization of these crystalline forms of zotepine hydrochloride is described. The invention also relates to the therapeutic use of the crystalline forms of zotepine hydrochloride to treat central nervous system disorders and to pharmaceutical compositions containing them.
摘要翻译: 本发明涉及盐酸妥洛司定的结晶形式,包括zotepine的盐酸盐结晶盐酸盐和盐酸妥替托盐酸盐与苯甲酸两种共晶体。 描述了盐酸替罗定的这些晶型的制备和表征。 本发明还涉及盐酸替罗他宾的结晶形式治疗中枢神经系统疾病和含有它们的药物组合物的治疗用途。
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