公开(公告)号：US20200096516A1

公开(公告)日：2020-03-26

申请号：US16469082

申请日：2017-12-28

Applicant: THE METHODIST HOSPITAL, dba HOUSTON METHODIST

Inventor： Ye Hu ,  Jia Fan ,  Kai Liang ,  Fei Liu ,  Dali Sun

IPC: G01N33/574 ,  G01N33/543

Abstract: A rapid, ultrasensitive and inexpensive nanoplasmon-enhanced scattering (nPES) assay that directly quantifies tumor-derived EVs from as little as 1 μ{umlaut over ({acute over (ι)})}, of plasma is described herein. This assay uses binding of gold nanospheres and nanorods with EV- and tumor-derived EV-specificities to produce a local plasmon effect that enhances tumor-derived EV detection sensitivity and specificity. This nPES approach is also a non-invasive method for assessing pancreatic cancer stage and treatment response that can be easily refined for clinical use, and is readily adapted for diagnosis and monitoring of other conditions with disease-specific EV proteins.

公开(公告)号：US20190064178A1

公开(公告)日：2019-02-28

申请号：US16119100

申请日：2018-08-31

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  HOUSTON METHODIST

Inventor： Ye Hu ,  Yang Bu

IPC: G01N33/68 ,  C01G23/053 ,  C01G23/08

Abstract: Certain embodiments of the invention provide TiO2 nanoshell particles, methods of fabricating TiO2 nanoshell particles, and methods of enriching peptides in a sample using TiO2 nanoshell particles.