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    Polypeptide of protein P140 and DNAS encoding it
    12.
    发明授权
    Polypeptide of protein P140 and DNAS encoding it 失效
    蛋白质P140的多肽和编码它的DNAS

    公开(公告)号：US5804411A

    公开(公告)日：1998-09-08

    申请号：US571785

    申请日：1995-12-13

    申请人： Hisao Tajima ,  Koichiro Kitagawa ,  Hiroyuki Ohno

    发明人： Hisao Tajima ,  Koichiro Kitagawa ,  Hiroyuki Ohno

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12N15/12 ,  C12P21/08 ,  C12P21/02 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improve the diabetes-derived hypoglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).

    摘要翻译： 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽， 制备方法 编码所述多肽的DNA; 载体衍生所述DNA; 宿主细胞转化所述载体; 所述多肽的抗体; 含有所述肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法，其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药剂，用于预防和/或治疗糖尿病的药剂，其特征在于含有可以将蛋白质p140的酪氨酸磷酸化的化合物作为活性成分，以及所述预防和/ 或治疗剂。 蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。 基于本发明的蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可改善糖尿病衍生的低血糖状况，而且可用于治疗和/或预防糖尿病，特别是非胰​​岛素依赖性 糖尿病（NIDDM）。

    Prolinal derivatives and pharmaceutical compositions thereof
    14.
    发明授权
    Prolinal derivatives and pharmaceutical compositions thereof 失效
    脯氨酸衍生物及其药物组合物

    公开(公告)号：US5262431A

    公开(公告)日：1993-11-16

    申请号：US836971

    申请日：1992-02-19

    申请人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

    发明人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

    IPC分类号： C07D207/08 ,  A61K31/40 ,  C07D213/24

    CPC分类号： C07D207/08

    摘要： A novel prolinal derivative of general formula: ##STR1## [wherein A represents a group of the general formula: ##STR2## (wherein one of R.sup.1 and R.sup.2 represents hydrogen atom and the other represents alkyl group of from 2 to 5 carbon atoms, alkoxy group of from 1 to 5 carbon atom(s), phenyl group, benzyl group, cycloalkyl group of from 4 to 6 carbon atoms or (cycloalkyl group of from 4 to 6 carbon atoms)--methyl group or R.sup.1 and R.sup.2 each represents, same or different, alkyl group of from 1 to 4 carbon atom(s).) or a group of the general formula: ##STR3## (wherein m represents an integer of from 3 to 6.) n represents an integer of from 3 to 10.D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, nitro group, trifluoromethyl group, alkyl or alkoxy group of from 1 to 4 carbon atom(s).]possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.

    摘要翻译： 一种新型的通式为：其中A表示通式为：IMA的基团（其中R 1和R 2中的一个表示氢原子，另一个表示2至5个碳原子的烷基） 原子，1〜5个碳原子的烷氧基，苯基，苄基，4〜6个碳原子的环烷基或（4〜6个碳原子的环烷基） - 甲基或者R 1和R 2各自 表示相同或不同的1至4个碳原子的烷基）或下列通式的基团：其中m表示3至6的整数。n表示从 D表示未被取代或被1至3个卤素原子，硝基，三氟甲基，1至4个碳原子的烷基或烷氧基取代的碳环或杂环]具有对脯氨酰内肽酶的抑制活性 ，因此可用于治疗和/或预防健忘症药物。

    Prolinal derivatives
    16.
    发明授权
    Prolinal derivatives 失效
    乳制品

    公开(公告)号：US5091406A

    公开(公告)日：1992-02-25

    申请号：US479493

    申请日：1990-02-07

    申请人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

    发明人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

    IPC分类号： C07D207/08

    CPC分类号： C07D207/08

    摘要： A prolinal derivative of general formula: ##STR1## [wherein A represents alkylene group of from 1 to 4 carbon atom(s) or saturated hydrocarbon ring of from 3 to 7 carbon atoms,n represents a number 2, 3 or 4,D represents carbocyclic or heterocyclic ring unsubstituted orsubstituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluoromethyl group.]. possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.

    Novel prolinal derivatives
    17.
    发明授权
    Novel prolinal derivatives 失效
    新颖的流涎衍生物

    公开(公告)号：US4977180A

    公开(公告)日：1990-12-11

    申请号：US151862

    申请日：1988-02-03

    申请人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

    发明人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

    IPC分类号： C07D207/08

    CPC分类号： C07D207/08

    摘要： A novel prolinal derivative of general formula: ##STR1## wherein A represents alkylene group of from 1 to 4 carbon atom(s) or saturated hydrocarbon ring of from 3 to 7 carbon atoms, n represents a number 2, 3 or 4, D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluromethyl group posses inhibitory activity on prolyl endopeptidase, and therefore are useful for treating and/or preventing agent for amnesia.

    Slip detection and traction control for a vehicle
    19.
    发明申请
    Slip detection and traction control for a vehicle 有权
    车辆的滑移检测和牵引力控制

    公开(公告)号：US20090228183A1

    公开(公告)日：2009-09-10

    申请号：US12074726

    申请日：2008-03-05

    申请人： Satoru Watabe ,  Hiroyuki Ohno

    发明人： Satoru Watabe ,  Hiroyuki Ohno

    IPC分类号： B60W40/12

    CPC分类号： B60K28/16 ,  B60T8/1706 ,  B60T8/175 ,  B60W2510/0638 ,  B60W2510/0652 ,  B60W2510/1005 ,  B60W2520/10 ,  B60W2710/0616 ,  B60W2710/0666 ,  Y10T477/755

    摘要： A slip detection system for a vehicle comprises an engine speed detector configured to detect an engine speed of an engine mounted in the vehicle, an engine speed increase rate detector configured to detect an increase rate in a predetermined time of the engine speed detected by the engine speed detector, and a slip determiner configured to integrate values of increase rates in respective predetermined times, from when the increase rate detected by the engine speed increase rate detector becomes larger than a first threshold until the increase rate becomes smaller than the first threshold, and to determine that a drive wheel of the vehicle is in a slip-state when an integrated value resulting from integration of the values of the increase rates becomes larger than a second threshold.

    摘要翻译： 一种用于车辆的滑动检测系统包括：发动机速度检测器，被配置为检测安装在车辆中的发动机的发动机转速;发动机速度增加率检测器，被配置为检测在发动机检测到的发动机转速的预定时间内的增加率 速度检测器和滑动判定器，其被配置为在从发动机速度增加率检测器检测到的增加率变得大于第一阈值直到增加速率变得小于第一阈值时，在各个预定时间内积分增加率的值，以及 当由增加率的值的积分导致的积分值变得大于第二阈值时，确定车辆的驱动轮处于滑动状态。

    Cytotoxic protein and utilization thereof
    20.
    发明授权
    Cytotoxic protein and utilization thereof 失效
    细胞毒性蛋白及其利用

    公开(公告)号：US07385035B2

    公开(公告)日：2008-06-10

    申请号：US10496384

    申请日：2002-12-05

    申请人： Hiroyuki Ohno ,  Hiromitsu Saisho ,  Hideki Tanzawa

    发明人： Hiroyuki Ohno ,  Hiromitsu Saisho ,  Hideki Tanzawa

    IPC分类号： C07K5/10

    CPC分类号： C07K14/205 ,  A61K38/164 ,  C07K16/121 ,  C12P21/02 ,  G01N2333/205 ,  Y10S435/81

    摘要： This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced by Helicobacter pylori and the use.This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.

    摘要翻译： 本发明涉及由幽门螺杆菌产生的新的细胞毒素蛋白（M毒素，粘液层破坏性毒素）及其用途。 本发明提供由幽门螺杆菌，部分肽和含有细胞毒性蛋白质的抗肿瘤剂产生的细胞毒性蛋白（M毒素）。 通过培养用含有编码细胞毒素蛋白的DNA的重组载体转化的转化体获得蛋白质。 本发明进一步提供了蛋白质的用途。