公开(公告)号：US07621948B2

公开(公告)日：2009-11-24

申请号：US10565142

申请日：2004-07-20

申请人： Howard C Herrmann ,  Nilesh Mankame ,  Suresh G. K. Ananthasuresh

发明人： Howard C Herrmann ,  Nilesh Mankame ,  Suresh G. K. Ananthasuresh

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/243 ,  Y10S623/904

摘要： A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design. The heart valve may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.

摘要翻译： 经皮插入的双稳态心脏瓣膜假体折叠在导管内，用于经血管输送到患者的心脏用于植入。 心脏瓣膜具有环形环，主体部件具有多个腿部，每个腿部在一端连接到环形环，通过施加外力从第一位置到第二位置可调节的爪，以允许进入 周围的心脏组织进入第二位置的爪，以及连接到环形环，身体构件和/或腿的小叶膜，小叶膜具有用于阻止血液流过的第一位置和用于允许血液流动的第二位置 通过。 心脏瓣膜被设计成使得当去除外力时，爪弹性地回复到第一位置，以便夹紧位于爪内的心脏组织，从而将心脏瓣膜保持在适当位置。 主体构件和爪可以集成成一体式设计。 心脏瓣膜可用作二尖瓣，主动脉瓣，肺动脉瓣或三尖瓣的假体，通过使环形圈适应于心脏的相应二尖瓣，主动脉，肺或三尖瓣开口。

公开(公告)号：US20080208328A1

公开(公告)日：2008-08-28

申请号：US11870001

申请日：2007-10-10

申请人： Joseph D. Antocci ,  David G. Lamphere ,  Salvatore Castro ,  Gregorio Ramon M. Abesames ,  Howard C. Herrmann

发明人： Joseph D. Antocci ,  David G. Lamphere ,  Salvatore Castro ,  Gregorio Ramon M. Abesames ,  Howard C. Herrmann

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2439

摘要： Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus. The second elongate element may be manipulated to remotely advance the valve prosthesis into the anatomical annulus to assume a position for supporting post-implantation function of the valve prosthesis in situ. The first elongate element may be further manipulated to remotely rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus and to thereby maintain the post-implantation position of the valve prosthesis in situ. Methods for valve prosthesis deployment are also provided.

摘要翻译： 提供了用于放置这种瓣膜假体的瓣膜假体系统和方法/系统，其有助于有效，可靠和微创的递送方式。 放置系统和方法允许瓣膜假体的远程操作和定位，使得可以实现相对于解剖结构（例如心脏环）的期望的放置。 瓣膜假体包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。 递送系统包括终止于瓣膜假体处的第一细长元件，并且可由操作者操纵以相对于柔性环远程旋转定位元件。 第二细长元件终止在瓣膜假体处，并且可由操作者操纵以将瓣膜假体向下远进地推进到解剖环形中。 第二细长元件可以被操纵以将瓣膜假体远程地推进到解剖环空中，以呈现用于在原位支撑瓣膜假体的植入后功能的位置。 可以进一步操作第一细长元件以相对于柔性环远程旋转定位元件，以使得定位元件接合与解剖学环带相关联的组织，并由此原位维持瓣膜假体的植入后位置。 还提供了用于瓣膜假体部署的方法。