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12 条记录 (耗时 0.015 秒)

    Thioxanthine Derivatives and Their Use as Inhibitors of MPO
    11.
    发明申请
    Thioxanthine Derivatives and Their Use as Inhibitors of MPO 失效
    硫代黄嘌呤衍生物及其作为MPO抑制剂的用途

    公开(公告)号：US20090149475A1

    公开(公告)日：2009-06-11

    申请号：US12295306

    申请日：2007-04-12

    申请人： Anna-Karin Tiden ,  Jenny Viklund

    发明人： Anna-Karin Tiden ,  Jenny Viklund

    IPC分类号： A61K31/52 ,  C07D473/02 ,  A61P11/00 ,  A61P9/10 ,  A61P25/00

    CPC分类号： C07D473/20 ,  C07D473/22

    摘要： There are disclosed novel compounds of Formula (I) wherein L, R1, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio- and cerebrovascular atherosclerotic disorders and peripheral artery disease and respiratory disorders.

    摘要翻译： 公开了式（I）的新化合物，其中L，R 1，X和Y如说明书中所定义，及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是MPO酶的抑制剂，因此特别可用于治疗或预防神经炎症性疾病，心脑血管动脉粥样硬化性疾病和外周动脉疾病和呼吸系统疾病。

    Novel Use
    12.
    发明申请
    Novel Use 审中-公开
    小说使用

    公开(公告)号：US20080096929A1

    公开(公告)日：2008-04-24

    申请号：US11577833

    申请日：2005-10-24

    申请人： Anna-Karin Tiden ,  Dominika Turek ,  Jenny Viklund

    发明人： Anna-Karin Tiden ,  Dominika Turek ,  Jenny Viklund

    IPC分类号： A61K31/4196 ,  A61K31/4439 ,  A61P29/00 ,  C07D249/10 ,  C07D401/06

    CPC分类号： C07D401/06 ,  C07D249/12 ,  C07D401/14 ,  C07D405/04

    摘要： There is disclosed the use of a compound of formula (I), (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (I) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.

    摘要翻译： 公开了在制备用于治疗或预防的药物中使用式（I），（I）的化合物，其中X，Y，W和Q如说明书中所定义，及其药学上可接受的盐， 的抑制酶髓过氧化物酶（MPO）的疾病或病症是有益的。 公开了某些新的式（I）化合物及其药学上可接受的盐及其制备方法。 式（I）化合物是MPO抑制剂，因此特别可用于治疗或预防神经炎症性疾病。