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16 条记录 (耗时 0.016 秒)

    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
    13.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use 有权
    1,4-二氮杂双环[3.2.2]壬基嘧啶衍生物及其医疗用途

    公开(公告)号：US08343960B2

    公开(公告)日：2013-01-01

    申请号：US12742627

    申请日：2008-11-13

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Ostergaard Nielsen ,  Gunnar M. Olsen ,  Tino Dyhring ,  Jeppe Kejser Christensen ,  John Paul Redrobe ,  Jens Damsgaard Mikkelsen

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Ostergaard Nielsen ,  Gunnar M. Olsen ,  Tino Dyhring ,  Jeppe Kejser Christensen ,  John Paul Redrobe ,  Jens Damsgaard Mikkelsen

    IPC分类号： A61P25/00 ,  A61K31/55 ,  C07D471/08

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基嘧啶衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    PEPTIDE AGONISTS OF GLP-1 ACTIVITY
    15.
    发明申请
    PEPTIDE AGONISTS OF GLP-1 ACTIVITY 审中-公开
    GLP-1活性的肽促进剂

    公开(公告)号：US20110245165A1

    公开(公告)日：2011-10-06

    申请号：US12770667

    申请日：2010-04-29

    申请人： Bjarne Due LARSEN ,  Jens Damsgaard Mikkelsen ,  Søren Neve

    发明人： Bjarne Due LARSEN ,  Jens Damsgaard Mikkelsen ,  Søren Neve

    IPC分类号： A61K38/28 ,  A61K38/26 ,  A61P3/10

    CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/26 ,  A61K47/62 ,  C07K14/57563

    摘要： Novel peptide agonists of GLP-1 activity useful for lowering blood glucose levels. The novel peptides comprise variants of the GLP-1 or the exendin-4 polypeptide sequence and are pharmacologically active and stable. These peptides are useful in the treatment of diseases that benefit from regulation of excess levels of blood glucose and/or regulation of gastric emptying, such as diabetes and eating disorders.

    摘要翻译： 用于降低血糖水平的GLP-1活性的新型肽激动剂。 新型肽包含GLP-1或毒蜥外泌肽-4多肽序列的变体，并且具有药理学活性和稳定性。 这些肽可用于治疗受益于调节过量血糖和/或调节胃排空的疾病，例如糖尿病和进食障碍。