公开(公告)号：US5429825A

公开(公告)日：1995-07-04

申请号：US904940

申请日：1992-06-26

申请人： Joseph P. Reo ,  Edward J. Roche

发明人： Joseph P. Reo ,  Edward J. Roche

IPC分类号： A61K9/16 ,  B01J2/14 ,  B01J2/16

CPC分类号： B01J2/16 ,  A61K9/1694 ,  B01J2/14

摘要： A process for producing granules by rotomelt granulation comprising mixing at least one powdered pharmaceutically active material and a powdered excipient material within a zone wherein both powdered materials are maintained in a fluidized state by a rising stream of gas in an apparatus having a rapidly rotating horizontal-disk located within a vertical vessel wherein said gas is at a temperature sufficient to cause at least one powdered material to at least partially melt thereby causing said powdered materials to aggregate and form granules.

摘要翻译： 一种通过滚筒造粒生产颗粒的方法，包括将至少一种粉末状药物活性物质和粉状赋形剂材料混合在一个区域内，其中两种粉末状材料在具有快速旋转水平 - 其中所述气体处于足以使至少一种粉末材料至少部分熔融的温度，从而使所述粉末材料聚集并形成颗粒。