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11.
公开(公告)号:US08198456B2
公开(公告)日:2012-06-12
申请号:US11955777
申请日:2007-12-13
申请人: Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
发明人: Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
IPC分类号: C07D401/04
CPC分类号: C07D401/04 , C07D211/90 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/14 , C07D471/04
摘要: This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
摘要翻译: 本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物,其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。
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公开(公告)号:US20060247213A1
公开(公告)日:2006-11-02
申请号:US10508169
申请日:2003-03-21
申请人: Brad Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
发明人: Brad Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
IPC分类号: A61K31/66 , C07D211/26 , C07F9/22 , C07F9/28 , A61K31/445
CPC分类号: C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要: Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式(I)的化合物,例如:(1)其中R 1,R 2,R 3和R 3, 本文描述的这些化合物可用作血浆羧肽酶B的抑制剂。本文还描述了含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。
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公开(公告)号:US08008325B2
公开(公告)日:2011-08-30
申请号:US12332619
申请日:2008-12-11
申请人: Brad O. Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
发明人: Brad O. Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
IPC分类号: A61K31/445 , C07D211/00
CPC分类号: C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要: Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下列通式(I)的化合物,其中R1,R2,R3和R4如本文所述,可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂和方法 用于合成这些化合物也在本文中描述。
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公开(公告)号:US20090093520A1
公开(公告)日:2009-04-09
申请号:US12332619
申请日:2008-12-11
申请人: Brad BUCKMAN , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendon Yuan
发明人: Brad BUCKMAN , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendon Yuan
IPC分类号: A61K31/445 , C07D211/60 , A61P7/02
CPC分类号: C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要: Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下列通式(I)的化合物,其中R1,R2,R3和R4如本文所述,可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂和方法 用于合成这些化合物也在本文中描述。
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公开(公告)号:US07084142B2
公开(公告)日:2006-08-01
申请号:US11331621
申请日:2006-01-12
申请人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号: A61K31/496 , C07D401/12
CPC分类号: C07D405/12 , C07D215/48 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of the following formula: where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式的化合物:其中m,n,R 1,R 2,R 3,R 4, 和R 6 6在本文中描述,可用作血小板二磷酸腺苷的抑制剂。 本文还描述了含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。
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公开(公告)号:US20060135532A1
公开(公告)日:2006-06-22
申请号:US11347768
申请日:2006-02-02
申请人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号: C07D241/04 , A61K31/495
CPC分类号: C07D295/205 , C07D215/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要: Compounds of the following formula (I): where A, a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式(I)的化合物:其中A,a,b,R 1,R 2,R 3,R 3, 4和4本文描述的,可用作血小板二磷酸腺苷的抑制剂。 本文还描述了含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。
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