公开(公告)号：US06555136B2

公开(公告)日：2003-04-29

申请号：US09992353

申请日：2001-11-13

申请人： Kamal K. Midha

发明人： Kamal K. Midha

IPC分类号： A61K926

CPC分类号： A61K31/485 ,  A61K9/1676 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2081 ,  A61K9/2853 ,  A61K9/4808 ,  A61K9/5078 ,  A61K9/5084 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4458 ,  A61K45/06 ,  A61K2300/00

摘要： Novel pharmaceutical dosage forms provide for pulsatile delivery of methylphenidate, i.e., release encapsulated drug in spaced apart “pulses.” The dosage forms are comprised of first, second and optionally third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads or particles, or may comprise a single tablet with the first, second and optionally third dosage units each representing an integral and discrete segment thereof. Methods of treatment using the pharmaceutical dosage forms are provided as well.

公开(公告)号：US06340476B1

公开(公告)日：2002-01-22

申请号：US09544732

申请日：2000-04-06

申请人： Kamal K. Midha ,  Theodore L. Iorio ,  Shubha Chungi

发明人： Kamal K. Midha ,  Theodore L. Iorio ,  Shubha Chungi

IPC分类号： A61K926

CPC分类号： A61K31/485 ,  A61K9/1676 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2081 ,  A61K9/2853 ,  A61K9/4808 ,  A61K9/5078 ,  A61K9/5084 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4458 ,  A61K45/06 ,  A61K2300/00

摘要： Novel pharmaceutical dosage forms provide for pulsatile delivery of methylphenidate, i.e., release encapsulated drug in spaced apart “pulses.” The dosage forms are comprised of first, second and optionally third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads or particles, or may comprise a single tablet with the first, second and optionally third dosage units each representing an integral and discrete segment thereof. Methods of treatment using the pharmaceutical dosage forms are provided as well.

公开(公告)号：US06312716B1

公开(公告)日：2001-11-06

申请号：US09562178

申请日：2000-05-02

申请人： Kamal K. Midha ,  Hans E. Junginger ,  Mark Hirsh

发明人： Kamal K. Midha ,  Hans E. Junginger ,  Mark Hirsh

IPC分类号： A61F1302

CPC分类号： A61K47/14 ,  A61K9/7023 ,  A61K31/137 ,  A61K47/12 ,  A61K47/22

摘要： The invention includes a patch and method for transdermal delivery of bupropion base. In the method of this invention, a patient is administered a bupropion base in an amount effective to alleviate withdrawal symptoms and to prevent or reduce craving of nicotine in said patient. Alternatively, an effective amount of bupropion base is delivered to alleviate depression in a patient or to treat obesity. A transdermal patch includes a bupropion base. The bupropion base can be mixed with an acceptable pharmaceutical carrier.

摘要翻译： 本发明包括用于安非他酮碱的透皮递送的贴剂和方法。 在本发明的方法中，患者以有效减轻戒断症状的量并且预防或减少所述患者中的尼古丁的渴望量施用安非他酮碱。 或者，递送有效量的安非他酮碱以缓解患者的抑郁症或治疗肥胖症。 透皮贴剂包括安非他酮碱。 安非他酮碱可与可接受的药物载体混合。