公开(公告)号：US4080450A

公开(公告)日：1978-03-21

申请号：US819280

申请日：1977-07-27

Applicant: Paul Croisier ,  Ludovic Rodriguez

Inventor： Paul Croisier ,  Ludovic Rodriguez

IPC: A61K31/395 ,  A61K31/535 ,  A61P25/28 ,  C07D223/16 ,  A61K31/55 ,  C07D413/06

CPC classification number: C07D223/16

Abstract: New physiologically active 2-carbamoyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-ones having the general formula ##STR1## wherein R.sub.1 is hydrogen or phenyl, R.sub.2 is morpholino or amino mono- or di-substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl or phenyl, R.sub.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.5 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.7 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkoxy, R.sub.8 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkyl, processes for the preparation thereof and pharmaceutical compositions containing the same. In particular, the compounds of this invention are useful in the treatment of memory disorders.

Abstract translation: 具有通式“IMAGE”的新的生理活性2-氨基甲酰基-1,2,4,5-四氢-3H-2-苯并吖庚因-3-酮其中R 1为氢或苯基，R 2为吗啉代或氨基单 - 或二 - 被C 1 -C 4 - 烷基，C 5 -C 6 - 环烷基或苯基取代，R 4是氢或C 1 -C 4 - 烷基，R 5是氢或C 1 -C 4烷基，R 7是氢，卤素或C 1 -C 4烷氧基，R 8是 氢，卤素或C 1 -C 4烷基，其制备方法和含有它们的药物组合物。 特别地，本发明的化合物可用于记忆障碍的治疗。