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公开(公告)号:US20090175863A1
公开(公告)日:2009-07-09
申请号:US12342285
申请日:2008-12-23
申请人: Elmar Kraus , Christoph Bruecher , Benjamin Daelken , Matthias Germer , Steffen Zeng , Frank Osterroth , Christoph Uherek , Silke Aigner
发明人: Elmar Kraus , Christoph Bruecher , Benjamin Daelken , Matthias Germer , Steffen Zeng , Frank Osterroth , Christoph Uherek , Silke Aigner
IPC分类号: A61K39/395 , C07K16/18 , C12N5/06 , C12N15/11
CPC分类号: C07K16/28 , A61K47/6803 , A61K47/6849 , A61K2039/505 , A61K2039/545 , C07K16/2896 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要: Disclosed is a human murine chimeric antibody which substantially retains the antigen binding region of its murine counterpart and displays improved binding affinities to the antigen and/or more homogenous binding to target cells.
摘要翻译: 公开了一种人鼠嵌合抗体,其基本上保留其鼠对应物的抗原结合区,并显示出与抗原的改善的结合亲和力和/或与靶细胞更均匀的结合。