公开(公告)号：US09982052B2

公开(公告)日：2018-05-29

申请号：US15272707

申请日：2016-09-22

申请人： MabQuest, SA

发明人： Giuseppe Pantaleo ,  Craig Fenwick

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K2039/507 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6893

摘要： This disclosure relates to binding agents with specificity for programmed cell death 1 (PD-1) and to methods for using the same to treat, prevent and/or ameliorate an infectious disease (e.g., human immunodeficiency virus (HIV)), cancer and/or autoimmunity. In addition, this disclosure identifies a novel binding patch (“P2”) on PD-1 that is linked with a previously unidentified functional activity of PD-1 that is distinct from the interaction site involved with either the PD-L1 or PD-L2 ligands. Furthermore, we demonstrate that antibodies that interact with this region of PD-1 are able to act as antagonists of PD-1 and that this antagonism is further enhanced with the addition of antibodies that act through the blockade of the PD-1/PD-L1/L2 interaction.

公开(公告)号：US20170226210A1

公开(公告)日：2017-08-10

申请号：US15329760

申请日：2015-08-05

申请人： MabQuest SA

发明人： Giuseppe Pantaleo ,  Craig Fenwick

IPC分类号： C07K16/28 ,  G01N33/68 ,  C07K16/10

CPC分类号： C07K16/2818 ,  A61K2039/507 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6893

摘要： This disclosure relates to binding agents with specificity for programmed cell death 1 (PD-1) and to methods for using the same to treat, prevent and/or ameliorate an infectious disease (e.g., human immunodeficiency virus (HIV)), cancer and/or autoimmunity.

公开(公告)号：US20170166642A1

公开(公告)日：2017-06-15

申请号：US15272707

申请日：2016-09-22

申请人： MabQuest SA

发明人： Giuseppe Pantaleo ,  Craig Fenwick

IPC分类号： C07K16/28

CPC分类号： C07K16/2818 ,  A61K2039/507 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6893

摘要： This disclosure relates to binding agents with specificity for programmed cell death 1 (PD-1) and to methods for using the same to treat, prevent and/or ameliorate an infectious disease (e.g., human immunodeficiency virus (HIV)), cancer and/or autoimmunity. In addition, this disclosure identifies a novel binding patch (“P2”) on PD-1 that is linked with a previously unidentified functional activity of PD-1 that is distinct from the interaction site involved with either the PD-L1 or PD-L2 ligands. Furthermore, we demonstrate that antibodies that interact with this region of PD-1 are able to act as antagonists of PD-1 and that this antagonism is further enhanced with the addition of antibodies that act through the blockade of the PD-1/PD-L1/L2 interaction.