公开(公告)号：US20140030255A1

公开(公告)日：2014-01-30

申请号：US13883485

申请日：2011-11-02

申请人： Andrey Loboda ,  Michael Nebozhyn ,  Hongyue Dai

发明人： Andrey Loboda ,  Michael Nebozhyn ,  Hongyue Dai

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： In one aspect, methods, markers, and expression signatures are disclosed for assessing the degree to which a cell sample has epithelial cell-like properties or mesenchymal cell-like properties. In another aspect, methods are provided for predicting whether a subject with cancer will respond to treatment with an agent, based on whether the cancer is classified as having a high or low EMT Signature Score.

摘要翻译： 一方面，公开了用于评估细胞样品具有上皮细胞样特性或间充质细胞样特性的程度的方法，标记和表达特征。 在另一方面，提供了用于基于癌症是否被分类为具有高或低EMT签名积分来预测癌症受试者是否将对药物治疗反应的方法。

公开(公告)号：US20110015869A1

公开(公告)日：2011-01-20

申请号：US12933936

申请日：2009-03-19

申请人： James Watters ,  Andrey Loboda ,  Michael Nebozhyn

发明人： James Watters ,  Andrey Loboda ,  Michael Nebozhyn

IPC分类号： G06F19/00

CPC分类号： G06F19/24 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G06F19/20

摘要： Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of growth factor pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating growth factor pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated growth factor signaling pathway; determining whether an agent modulates the growth factor signaling pathway in sample; predicting response of a subject to an agent that modulates the growth factor signaling pathway; assigning treatment to a subject; and predicting evaluating the pharmacodynamic effects of cancer therapies designed to regulate growth factor pathway signaling.

摘要翻译： 公开了用于评估细胞样品或受试者中生长因子途径信号传导的调节状态的方法，生物标志物和表达特征。 更具体地，本发明的几个方面提供了一组基因，其可以用作用于评估样品中生长因子途径去调节状态的生物标志物和基因特征; 将细胞样品分类为具有失调或调节的生长因子信号传导途径; 确定试剂是否调节样品中的生长因子信号通路; 预测受试者对调节生长因子信号通路的药剂的反应; 为受试者分配治疗; 并预测评估设计用于调节生长因子途径信号传导的癌症疗法的药效学作用。