公开(公告)号：US07138530B2

公开(公告)日：2006-11-21

申请号：US10515554

申请日：2003-05-28

Applicant: Nalin Subasinghe ,  Ehab Khalil ,  Kristi A. Leonard ,  Farah Ali ,  Heather Hufnagel ,  Jeremy M. Travins ,  Shelley K. Ballentine ,  Kenneth T. Wilson ,  Maxwell D. Cummings ,  Wenxi Pan ,  Joan Gushue ,  Sanath Meegalla ,  Mark Wall ,  Jinsheng Chen ,  Jonathan M. Rudolph ,  Hui Huang

Inventor： Nalin Subasinghe ,  Ehab Khalil ,  Kristi A. Leonard ,  Farah Ali ,  Heather Hufnagel ,  Jeremy M. Travins ,  Shelley K. Ballentine ,  Kenneth T. Wilson ,  Maxwell D. Cummings ,  Wenxi Pan ,  Joan Gushue ,  Sanath Meegalla ,  Mark Wall ,  Jinsheng Chen ,  Jonathan M. Rudolph ,  Hui Huang

IPC: C07D333/32 ,  A61K31/38

CPC classification number: C07D417/12 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D495/04 ,  C07F7/0812 ,  C07F9/655345

Abstract: Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.

Abstract translation: 公开了一种治疗由补体级联的经典途径介导的急性或慢性病症症状的方法，包括向需要这种治疗的哺乳动物施用治疗有效量的式（I）化合物或溶剂合物， 水合物或其药学上可接受的盐; 其中R 1，R 2，R 3，R 4和R 7， 在本说明书中定义，Z是SO或SO 2，Ar是如本文所定义的芳族或杂芳族基团。