公开(公告)号：US20090023631A1

公开(公告)日：2009-01-22

申请号：US12174769

申请日：2008-07-17

申请人： Z. Paul Lorenc ,  Robert C. Di Luccio

发明人： Z. Paul Lorenc ,  Robert C. Di Luccio

IPC分类号： A61K38/28 ,  A61K38/18

CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K35/28 ,  A61K38/1841 ,  A61K38/28 ,  A61K47/36

摘要： A composition for augmenting soft tissue and drug delivery is provided. The composition includes an active ingredient, a carrier, and a cross-linking agent, wherein the carrier is cross-linked with the cross-linking agent and the active ingredient is combined with the cross-linked carrier into a combination having a therapeutic effect. Techniques are also provided for producing a composition for augmenting soft tissue. Also, techniques are provided for soft tissue augmentation. Additionally, techniques are also provided for delivering a composition.

摘要翻译： 提供了用于增强软组织和药物递送的组合物。 该组合物包括活性成分，载体和交联剂，其中载体与交联剂交联，活性成分与交联载体组合成具有治疗效果的组合。 还提供了用于生产用于增加软组织的组合物的技术。 此外，提供了用于软组织增强的技术。 此外，还提供了用于递送组合物的技术。

公开(公告)号：US4673565A

公开(公告)日：1987-06-16

申请号：US730064

申请日：1985-05-03

申请人： Robert C. Di Luccio ,  Ray B. Duggins ,  Eli Shefter

发明人： Robert C. Di Luccio ,  Ray B. Duggins ,  Eli Shefter

IPC分类号： A61J3/07 ,  A61K9/00 ,  A61K9/22 ,  A61K9/50 ,  A61K9/70

CPC分类号： A61K9/0092 ,  A61K9/70 ,  Y10S514/965

摘要： Pharmaceutical compositions are provided which contain hollow fine tube drug delivery systems. The compositions comprise a pharmaceutically suitable carrier, preferably in the form of a capsule, tablet, suspension, or suppository, and at least one drug delivery system which consists essentially of (1) a polymeric tube having a membrane outer sheath and a hollow core, and (2) at least one drug compound contained within the core, said system contained in the composition in an amount sufficient to deliver a therapeutic amount of the drug contained therein at a predetermined rate over a predetermined period of time. By varying the polymer, the permeability of the outer sheath, the drug, the drug concentration in the hollow core of the tube, the tube diameter, the tube length, the tube core diameter, and the sealing of the tube ends, a wide variety of drug therapeutic amounts, rates and dosing times can be achieved.

摘要翻译： 提供了含有中空细管药物递送系统的药物组合物。 组合物包含药学上合适的载体，优选以胶囊，片剂，悬浮液或栓剂的形式，以及至少一种药物递送系统，其基本上由（1）具有膜外护套和中空芯的聚合物管组成， 和（2）包含在核心内的至少一种药物化合物，所述系统包含在组合物中，其量足以在预定时间内以预定的速率输送治疗量的药物。 通过改变聚合物，外鞘的渗透性，药物，管的中空芯中的药物浓度，管直径，管长度，管芯直径和管末端的密封，种类繁多 的药物治疗量，速率和给药时间可以实现。