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公开(公告)号：US08911495B2
公开(公告)日：2014-12-16
申请号：US13257196
申请日：2010-03-16
Applicant: Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
Inventor： Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
IPC: A61F2/14 , A61F9/007 , A61M31/00 , A61L27/50 , A61L27/14 , A61L27/04 , A61M25/01 , A61M25/04 , A61M25/00 , A61F9/00
CPC classification number: A61F9/00772 , A61F9/0017 , A61F2210/0014 , A61L27/04 , A61L27/14 , A61L27/50 , A61L2400/16 , A61L2430/16 , A61M25/00 , A61M25/01 , A61M25/04 , A61M31/002
Abstract: An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.
Abstract translation: 鼻泪管或小管植入物形式的可植入眼科装置（10）被配置用于在鼻泪管排出系统处或附近使用。 在展开状态下，装置（10）可以包括细长主体（25），可操作地连接到细长主体（25）的锚固件（15），设置在细长主体（32）的外圆周上的径向扩张的闭塞特征 ）和凸缘（30）。 细长主体（25）可以限定被配置为接受药物治疗（55）的管腔（35）。 装置（10）由诸如形状记忆聚合物的形状记忆材料制成。
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公开(公告)号：US08685089B2
公开(公告)日：2014-04-01
申请号：US13441754
申请日：2012-04-06
Applicant: Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
Inventor： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
IPC: A61F2/16
CPC classification number: B29D11/023 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2002/16905 , A61F2210/0014 , A61F2210/0019 , A61F2210/0023 , A61L27/16 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29L2011/0016 , C08L33/08 , C08L33/10 , C08F2220/1825 , C08F2222/108 , C08F226/02 , C08F2220/302
Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。
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公开(公告)号：US20130165949A1
公开(公告)日：2013-06-27
申请号：US13635565
申请日：2011-03-17
Applicant: Jeffrey Olson , Bryan Rech , Craig Lanning , Mike Erlanger , Robin Shandas
Inventor： Jeffrey Olson , Bryan Rech , Craig Lanning , Mike Erlanger , Robin Shandas
IPC: A61B17/10
CPC classification number: A61B17/00 , A61B17/064 , A61B17/068 , A61B2017/00867 , A61B2017/00893 , A61B2017/061 , A61B2017/0649 , A61F2/14 , A61F9/007 , A61F2210/0014
Abstract: A soft tissue coaptor and a soft tissue coaptor deployment device are disclosed which deliver a soft tissue coaptor or clip to a desired location for tissue repair. The soft tissue coaptor and soft tissue coaptor deployment device have particular application in surgical and microsurgical settings such as cardiac, vascular, and ophthalmic surgery.
Abstract translation: 公开了一种软组织触管器和软组织触管部署装置，其将软组织触管器或夹子输送到期望的位置用于组织修复。 软组织浸液器和软组织导管装置在手术和显微外科设备中具有特别的应用，例如心脏，血管和眼科手术。
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公开(公告)号：US20130085518A1
公开(公告)日：2013-04-04
申请号：US13516549
申请日：2010-12-15
Applicant: Julie Trommeter , Jeffrey P. Castleberry , William Aldrich , Robin Shandas , Jim Fogelberg , Mike Lyons
Inventor： Julie Trommeter , Jeffrey P. Castleberry , William Aldrich , Robin Shandas , Jim Fogelberg , Mike Lyons
IPC: A61M29/00
CPC classification number: A61M29/00 , A61B17/12022 , A61B17/12113 , A61B17/12172 , A61B2017/00867 , A61B2017/00871 , A61B2017/12054 , A61L31/04 , A61L2400/16 , C08L2201/12
Abstract: A shape memory coiling device (5) for occluding a vessel or other vascular target includes a shape memory polymer material. The shape memory material is formed in a formation state as a plurality of coiled members (10) and then constrained in a pre-deployed state as a plurality of elongate members (10) configured for delivery through a delivery device wherein the plurality of elongate members (10) are aligned axially with respect to each other and the delivery device (20). The shape memory material may be formed in an intra-deployed state such that at least one of the plurality of elongate members (10) will anchor the device (5) before filling the vascular target and becoming a coiled member. The shape memory material is formed in a deployed state as a plurality of coiled members (10). In some embodiments, the vascular target is an aneurysm.
Abstract translation: 用于封闭容器或其它血管靶的形状记忆卷取装置（5）包括形状记忆聚合物材料。 形状记忆材料形成为多个线圈构件（10）的形成状态，然后被约束为预先展开状态，作为构造成通过输送装置输送的多个细长构件（10），其中多个细长构件 （10）相对于彼此和输送装置（20）轴向对准。 形状记忆材料可以形成为处于展开状态，使得多个细长构件（10）中的至少一个在填充血管目标之前锚定装置（5）并变成线圈构件。 形状记忆材料形成为多个卷绕构件（10）处于展开状态。 在一些实施方案中，血管靶是动脉瘤。
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公开(公告)号：US20100152839A1
公开(公告)日：2010-06-17
申请号：US12608714
申请日：2009-10-29
Applicant: Robin Shandas , Avery Nelson , Bryan Rech , Devatha P. Nair , Michael B. Lyons , Jeffrey Paul Castleberry , Timothy Francis Scott
Inventor： Robin Shandas , Avery Nelson , Bryan Rech , Devatha P. Nair , Michael B. Lyons , Jeffrey Paul Castleberry , Timothy Francis Scott
CPC classification number: A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/2469 , A61F2/2475 , A61F2/88 , A61F2230/0091 , B29C61/0608 , B29L2031/7534 , Y10T156/1031
Abstract: A prosthetic medical device is formed by the combination of a biological tissue a shape memory polymer structure. The biological tissue provides an in-situ physiological function of the device. The shape memory polymer provides a capability for minimizing the device profile during insertion and then deploying after placement into a memory shape that achieves suitable mechanical structure and stability within an anatomical lumen or cavity. This configuration may be applied to form various prosthetic devices including aortic, mitral, and tricuspid valves in the heart; venous valves; anti-reflux valves for the lower esophageal sphincter; and other biological valve structures. Alternatively, an entirely non-biologic implementation using only shape memory polymer-based structures may be used as a prosthetic valve device.
Abstract translation: 假体医疗装置通过生物组织与形状记忆聚合物结构的组合形成。 生物组织提供了该装置的原位生理功能。 形状记忆聚合物提供了在插入期间最小化装置轮廓的能力，然后在放置到在解剖腔或腔内实现合适的机械结构和稳定性的记忆形状之前展开。 这种构造可以应用于形成心脏中的主动脉瓣，二尖瓣和三尖瓣的各种假体装置; 静脉瓣; 用于下食道括约肌的抗回流阀; 和其他生物瓣膜结构。 或者，仅使用形状记忆聚合物基结构的完全非生物学实施方式可以用作假体瓣膜装置。
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16.发明授权
公开(公告)号：US08846777B2
公开(公告)日：2014-09-30
申请号：US12988983
申请日：2009-04-22
Applicant: Christopher Bowman , Neil Cramer , Robin Shandas , Devatha P. Nair
Inventor： Christopher Bowman , Neil Cramer , Robin Shandas , Devatha P. Nair
IPC: C03C25/10 , C08G18/67 , C08J3/28 , C08F2/46 , C08G61/04 , C09D175/16 , C08F290/06 , C08G18/10 , B29C59/16 , C08F2/50 , C08F2/48 , A61L27/50
CPC classification number: C08G18/672 , A61F2/82 , A61L27/18 , A61L27/50 , A61L31/06 , A61L31/14 , A61L2400/16 , B29C59/16 , C08F2/46 , C08F2/48 , C08F2/50 , C08F290/067 , C08G18/10 , C08G18/3206 , C08G18/3876 , C08G18/673 , C08G18/753 , C08G2280/00 , C09D175/16 , C08L75/04
Abstract: A variety of biomedical devices are provided which include thiol-ene or thiol-yne shape memory polymers. The biomedical devices of the invention are capable of exhibiting shape memory behavior at physiological temperatures and may be used in surgical procedures. Methods of making the devices of the invention are also provided.
Abstract translation: 提供了各种生物医学装置，包括硫醇烯或硫醇阴形状记忆聚合物。 本发明的生物医学装置能够在生理温度下表现出形状记忆行为，并可用于外科手术。 还提供了制造本发明的装置的方法。
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公开(公告)号：US20140172094A1
公开(公告)日：2014-06-19
申请号：US14026832
申请日：2013-09-13
Applicant: Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech , Michael D. Lowery , Daniel Urbaniak
Inventor： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech , Michael D. Lowery , Daniel Urbaniak
CPC classification number: A61L27/16 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2/1659 , A61F9/007 , A61F2002/1683 , A61F2002/169 , A61F2002/169053 , A61F2002/1696 , A61F2002/16965 , A61F2210/0014 , A61F2240/001 , A61L27/26 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29D11/023 , B29K2995/0037 , B29L2011/0016 , B29L2031/7532 , C08L33/08 , C08L33/10
Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45
Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值
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18.发明申请DIRECT ECHO PARTICLE IMAGE VELOCIMETRY FLOW VECTOR MAPPING ON ULTRASOUND DICOM IMAGES 审中-公开直接ECHO颗粒图像速度矢量图在超声DICOM图像上映射
公开(公告)号：US20140147013A1
公开(公告)日：2014-05-29
申请号：US13879006
申请日：2011-10-11
Applicant: Robin Shandas , Fuxing Zhang , Jiusheng Chen , Luciano A. Mazzaro
Inventor： Robin Shandas , Fuxing Zhang , Jiusheng Chen , Luciano A. Mazzaro
CPC classification number: A61B8/14 , A61B8/481 , A61B8/5207 , A61B8/5246 , G01S15/8981 , G01S15/8984 , G06T7/0016
Abstract: An Echo PIV analysis process, apparatus and algorithm are developed to reduce noise and analyze DICOM images representing a fluid flow of a plurality of particles. A plurality of DICOM images representing sequential image pairs of a plurality of particles is received. The plurality of DICOM sequential image pairs are grouped. The sequential image pairs are correlated to create N cross correlation maps. An average cross-correlation transformation is applied to each cross correlation map to create an image pair vector map for each image pair. A maximizing operation is applied to one or more of the N adjacent image pair vector maps to create a modified image pair vector map for the one or more of the N image pairs. The maps are combined to create a corresponding temporary vector map that are averaged to obtain a mean velocity vector field of the sequential image pairs.
Abstract translation: 开发了回波PIV分析过程，装置和算法以减少噪声并分析表示多个粒子的流体流的DICOM图像。 接收表示多个粒子的连续图像对的多个DICOM图像。 多个DICOM顺序图像对被分组。 顺序图像对被相关以产生N个互相关图。 将平均互相关变换应用于每个互相关图以为每个图像对创建图像对矢量图。 将最大化操作应用于N个相邻图像对矢量图中的一个或多个，以创建N个图像对中的一个或多个的修改图像对矢量图。 将地图组合以产生平均以获得顺序图像对的平均速度矢量场的相应临时矢量图。
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公开(公告)号：US20130277890A1
公开(公告)日：2013-10-24
申请号：US13820601
申请日：2011-11-04
Applicant: Christopher Bowman , Devatha Nair , Neil Cramer , Robin Shandas
Inventor： Christopher Bowman , Devatha Nair , Neil Cramer , Robin Shandas
IPC: C08L81/02
CPC classification number: C08L81/02 , A61L27/14 , A61L27/50 , A61L2400/16 , C08F2/00 , C08F2/48 , C08G75/23 , C08G2280/00 , C08J3/243 , C08J3/244 , C08J3/28 , C08J2333/14 , C08L75/16 , G02B1/043
Abstract: The present invention includes compositions that are useful to prepare dual-cure shape memory polymer systems. The present invention further provides methods of generating a shape memory polymer, optical device, polymer pad with an imprint, or suture anchor system.
Abstract translation: 本发明包括可用于制备双重固化形状记忆聚合物体系的组合物。 本发明还提供了产生形状记忆聚合物，光学装置，具有印记的聚合物垫或缝线锚定系统的方法。
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公开(公告)号：US20120232651A1
公开(公告)日：2012-09-13
申请号：US13441754
申请日：2012-04-06
Applicant: Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
Inventor： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
IPC: A61F2/16
CPC classification number: B29D11/023 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2002/16905 , A61F2210/0014 , A61F2210/0019 , A61F2210/0023 , A61L27/16 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29L2011/0016 , C08L33/08 , C08L33/10 , C08F2220/1825 , C08F2222/108 , C08F226/02 , C08F2220/302
Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。
