公开(公告)号：US20100285040A1

公开(公告)日：2010-11-11

申请号：US11985871

申请日：2007-11-16

Applicant: Iacob Mathiesen ,  Torunn Elisabeth Tjelle ,  Rune Kjeken ,  Dietmar Paul Rabussay ,  Feng Lin

Inventor： Iacob Mathiesen ,  Torunn Elisabeth Tjelle ,  Rune Kjeken ,  Dietmar Paul Rabussay ,  Feng Lin

IPC: A61K39/00 ,  A61K31/7088 ,  A61P37/04

CPC classification number: A61K39/00 ,  A61K2039/545

Abstract: Disclosed are methods of enhancing immune responses. Such methods involve the administration of vaccine compositions to different tissues to elicit an enhanced immune response. The enhanced response arises from the vaccination and boosting route of administration in two separate patient tissues, for example, by first administering a priming vaccination into skin and later administering a boost vaccination in muscle. In each case, priming and boosting, the administration of the vaccine composition is preferably carried out using contemporaneous electroporation-assisted delivery of the antigenic agent.

Abstract translation: 公开了增强免疫应答的方法。 这样的方法涉及向不同组织施用疫苗组合物以引发增强的免疫应答。 增强的反应来自于在两个单独的患者组织中的接种和加强给药途径，例如，首先将皮下注射疫苗接种，然后在肌肉中施用加强免疫接种。 在每种情况下，引发和加强疫苗组合物的施用优选使用同时进行的抗原性电穿孔辅助递送来进行。

公开(公告)号：US20080045880A1

公开(公告)日：2008-02-21

申请号：US11804703

申请日：2007-05-18

Applicant: Rune Kjeken ,  Iacob Mathiesen ,  Elisabeth Tjelle ,  George McHugh

Inventor： Rune Kjeken ,  Iacob Mathiesen ,  Elisabeth Tjelle ,  George McHugh

IPC: A61N1/30

CPC classification number: A61N1/327 ,  A61N1/0502

Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue

Abstract translation: 描述了用于在各种医疗应用中向体内给组织施用分子的装置和方法，所述装置包括单针电极，其提供当将针插入诸如皮肤或肌肉的组织到脉冲组织时的能力 具有足够的非均匀电场，使得当细针插入所述组织时沿着或靠近由针制成的轨道的细胞位置可逆地定位