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公开(公告)号：US10435468B2
公开(公告)日：2019-10-08
申请号：US15622411
申请日：2017-06-14
发明人： Timothy S. Lewis , Che-Leung Law
摘要： Disclosed are antibodies, including antibody drug conjugates, that specifically bind to NTB-A. Also disclosed are methods for using the anti-NTB-A antibodies to detect or modulate activity of (e.g., inhibit proliferation of) an NTB-A-expressing cell, as well as for diagnoses or treatment of diseases or disorders (e.g., cancer) associated with NTB-A-expressing cells. Further disclosed is a method of treating multiple myeloma using an anti-NTB-A antibody drug conjugate, which optionally includes an anti-NTB-A antibody as disclosed herein.
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公开(公告)号：US10391181B2
公开(公告)日：2019-08-27
申请号：US15967276
申请日：2018-04-30
发明人： Hui Li , Shan Jiang , Mary Wallace , Damon Meyer
IPC分类号： C07K19/00 , A61K9/08 , A61K47/18 , A61K47/26 , A61K47/40 , A61K31/5517 , A61K47/68 , C07D519/00 , B01D61/14 , A61K47/69 , A61K9/19
摘要： Disclosed are formulations, including both liquid and lyophilized formulations, comprising a benzodiazepine antibody-drug conjugate (ADC) and a cyclodextrin. Also disclosed are methods of purifying mixtures comprising benzodiazepine antibody-drug conjugates and process drug-related impurities.
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13.发明申请公开(公告)号：US20190167806A1
公开(公告)日：2019-06-06
申请号：US16324198
申请日：2017-08-09
发明人： Philip Moquist
IPC分类号： A61K47/68 , C07D403/04 , A61K47/65 , A61K31/40 , A61K47/54 , A61K47/60 , C07K16/28 , A61P35/00
摘要： Compounds and compositions are disclosed in which a Drug Unit is linked to a targeting Ligand Unit through a self-stabilizing Linker Unit from which a drug compound or active drug moiety is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
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公开(公告)号：US20190015517A1
公开(公告)日：2019-01-17
申请号：US15781244
申请日：2016-12-02
发明人： Patrick J. Burke , Joel Courter
IPC分类号： A61K47/55 , A61K47/64 , A61K47/65 , A61K47/68 , A61K31/454 , A61K38/05 , A61K38/06 , A61K9/08 , A61K9/00 , A61P35/02
摘要： Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
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公开(公告)号：US20180296693A1
公开(公告)日：2018-10-18
申请号：US15943527
申请日：2018-04-02
发明人： Daulet SATPAYEV , Robert Kendall MORRISON , Karen Jane Meyrick MORRISON , Jean GUDAS , Aya JAKOBOVITS , Michael TORGOV , Zili AN
IPC分类号： A61K47/68
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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16.发明申请公开(公告)号：US20180155677A1
公开(公告)日：2018-06-07
申请号：US15729258
申请日：2017-10-10
发明人： Stephen C. ALLEY , Scott C. Jeffrey , Django SUSSMAN , Dennis R. BENJAMIN , Brian TOKI , Patrick J. BURKE
CPC分类号： C12N5/0037 , C07H13/04 , C07K16/00 , C07K2317/72 , C07K2317/732
摘要： The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
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公开(公告)号：US20170333556A1
公开(公告)日：2017-11-23
申请号：US15522614
申请日：2015-10-29
发明人： Shyra Gardai , Che-Leung Law , Stanford Peng , Jing Yang , Haley Neff-LaFord
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： A61K39/3955 , A61K39/395 , A61K39/39558 , A61K2039/505 , A61K2039/507 , A61K2039/545 , A61M25/0012 , A61M25/0017 , A61M25/002 , A61M25/0068 , C07K16/2878 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/92
摘要： This invention relates methods of using a non-fucosylated anti-CD40 antibody for treatment of cancer and chronic infectious diseases.
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公开(公告)号：US09732084B2
公开(公告)日：2017-08-15
申请号：US14072904
申请日：2013-11-06
发明人： Philip Wilson Howard , Luke Masterson , Arnaud Tiberghien , Scott Jeffrey , Patrick Burke , Peter Senter
IPC分类号： C07D487/04 , C07D519/00 , A61K47/48
CPC分类号： C07D487/04 , A61K47/6803 , A61K47/6849 , A61K47/6851 , C07D519/00
摘要： Pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds.
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公开(公告)号：US09713647B2
公开(公告)日：2017-07-25
申请号：US15181900
申请日：2016-06-14
IPC分类号： C07D487/04 , A61K47/48 , C07D471/04 , A61K31/5517
CPC分类号： A61K31/5517 , A61K47/55 , A61K47/6803 , A61K47/6849 , A61K47/6889 , A61P35/00 , C07D487/04
摘要： A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of: wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is SOzM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
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公开(公告)号：US20170204180A1
公开(公告)日：2017-07-20
申请号：US15411947
申请日：2017-01-20
IPC分类号： C07K16/28
摘要： The invention provides murine, chimeric, and humanized antibodies that specifically hind to CD33. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting CD33.
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