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公开(公告)号:US07956068B2
公开(公告)日:2011-06-07
申请号:US12743143
申请日:2008-11-03
申请人: Rebekah J. Carson , Lee Fader , Stephen Kawai , Serge R. Landry , Youla S. Tsantrizos , Christian Brochu , Sebastien Morin , Mathieu Parisien , Bruno Simoneau
发明人: Rebekah J. Carson , Lee Fader , Stephen Kawai , Serge R. Landry , Youla S. Tsantrizos , Christian Brochu , Sebastien Morin , Mathieu Parisien , Bruno Simoneau
IPC分类号: C07D495/04 , A61K31/4365
CPC分类号: C07D495/04 , C07D519/00
摘要: The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.
摘要翻译: 本发明涉及其中c,X,Y,R 2,R 3,R 4和R 6如本文所定义的式(I)化合物,其用于治疗人类免疫缺陷病毒(HIV)感染的组合物和用途。 特别地,本发明提供HIV整合酶的新型抑制剂,含有这些化合物的药物组合物和使用这些化合物治疗HIV感染的方法。
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公开(公告)号:US20090113606A1
公开(公告)日:2009-05-07
申请号:US12318822
申请日:2009-01-09
申请人: Bastien Jourde , Martin Laberge , Sebastien Morin
发明人: Bastien Jourde , Martin Laberge , Sebastien Morin
摘要: A sports helmet having a front shell and a rear shell, and a plurality of straps interconnecting the front and rear shells. At least one of the straps is connected to the front shell along an inner surface thereof, and a portion of the at least one of the straps extending from the rear shell to the connection with the front shell is completely contained inside the helmet.
摘要翻译: 一种具有前壳和后壳的运动头盔,以及连接前壳和后壳的多个皮带。 所述带中的至少一个沿其内表面连接到所述前壳,并且从所述后壳延伸到与所述前壳的连接的所述至少一个所述带的一部分完全容纳在所述头盔内。
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公开(公告)号:US07517998B2
公开(公告)日:2009-04-14
申请号:US11137831
申请日:2005-05-24
申请人: Patrick Deroy , Anne-Marie Faucher , Alexandre Gagnon , Serge Landry , Sebastien Morin , Jeffrey O'Meara , Bruno Simoneau , Bounkham Thavonekham , Christiane Yoakim
发明人: Patrick Deroy , Anne-Marie Faucher , Alexandre Gagnon , Serge Landry , Sebastien Morin , Jeffrey O'Meara , Bruno Simoneau , Bounkham Thavonekham , Christiane Yoakim
IPC分类号: A61K31/41 , C07D257/04
CPC分类号: C07D257/04 , A61K31/41 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/495 , A61K31/5377 , A61K31/541 , C07D231/18 , C07D233/84 , C07D249/08 , C07D249/12 , C07D277/36 , C07D285/06 , C07D285/125 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要: Compounds of formula (I): wherein Ar, X, R1, R2, R3 and R4 are as defined herein. The compounds are useful as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV.
摘要翻译: 式(I)化合物:其中Ar,X,R 1,R 2,R 3和R 4如本文所定义。 该化合物可用作针对野生型和单突变或双突变株的逆转录酶抑制剂。
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公开(公告)号:US20080053583A1
公开(公告)日:2008-03-06
申请号:US11852346
申请日:2007-09-10
申请人: Gia Nguyen , Sebastien Morin , Anne-France Gabrielle Jeanne-Marie Cambron , Xavier Sebastien Benoit Fraipont
发明人: Gia Nguyen , Sebastien Morin , Anne-France Gabrielle Jeanne-Marie Cambron , Xavier Sebastien Benoit Fraipont
IPC分类号: B60C11/00
CPC分类号: B60C11/0083 , B60C9/28 , B60C11/00 , B60C11/0332
摘要: A pneumatic radial ply passenger tire (10) having a tread (20), a casing with two sidewalls (14, 16), one or more radial plies (18) extending from and wrapped about two annular beads (13) and a belt reinforcement structure (15) located radially between the tread and the plies. The tread has a first contour-defining curve extending outwards from the equatorial plane of the tire towards the sidewalls, an adjacent second contour-defining curve disposed between the first contour defining curve and the sidewalls and an adjacent third contour defining curve extending outwards from the second contour defining curve and the sidewalls. The first, second and third contour-defining curves have first (R1) and second (R2) and third (R3) radii chosen such that R2>R1>R3.
摘要翻译: 一种具有胎面(20)的气动径向帘布层乘客轮胎(10),具有两个侧壁(14,16)的壳体,从两个环形胎圈(13)延伸并缠绕在两个环形胎圈(13)上的一个或多个径向帘布层(18) 结构(15)径向位于胎面和帘布层之间。 胎面具有从轮胎的赤道平面向侧壁向外延伸的第一轮廓限定曲线,设置在第一轮廓限定曲线和侧壁之间的相邻的第二轮廓限定曲线和从该轮胎向外延伸的相邻的第三轮廓限定曲线 第二轮廓定义曲线和侧壁。 第一,第二和第三轮廓定义曲线具有第一(R 1)和第二(R 2)和第三(R 3)半径,使得R 2> R 1> R 3。
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公开(公告)号:USD556670S1
公开(公告)日:2007-12-04
申请号:US29270076
申请日:2006-12-14
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公开(公告)号:USD492642S1
公开(公告)日:2004-07-06
申请号:US29190952
申请日:2003-09-29
申请人: Richard Heinen , Sebastien Morin
设计人: Richard Heinen , Sebastien Morin
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公开(公告)号:US08349839B2
公开(公告)日:2013-01-08
申请号:US12756276
申请日:2010-04-08
申请人: Claudio Sturino , Patrick Deroy , Martin Duplessis , Paul J. Edwards , Anne-Marie Faucher , Teddy Halmos , Clint James , Jean-Eric Lacoste , Eric Malenfant , Joannie Minville , Louis Morency , Sebastien Morin , Martin Tremblay , Christiane Yoakim
发明人: Claudio Sturino , Patrick Deroy , Martin Duplessis , Paul J. Edwards , Anne-Marie Faucher , Teddy Halmos , Clint James , Jean-Eric Lacoste , Eric Malenfant , Joannie Minville , Louis Morency , Sebastien Morin , Martin Tremblay , Christiane Yoakim
IPC分类号: A61K31/501 , A61K31/34 , C07D237/36 , C07D307/92
CPC分类号: C07D491/048 , C07D487/04 , C07D491/147 , C07D513/04 , C07D519/00
摘要: Compounds of formula (I): wherein R1, R2, A1, A2, A3, A4, X and Y are as defined herein, are useful as inhibitors of HIV replication.
摘要翻译: 式(I)化合物:其中R1,R2,A1,A2,A3,A4,X和Y如本文所定义,可用作HIV复制的抑制剂。
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公开(公告)号:USD637766S1
公开(公告)日:2011-05-10
申请号:US29352367
申请日:2009-12-18
申请人: Sebastien Morin
设计人: Sebastien Morin
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公开(公告)号:US20100305115A1
公开(公告)日:2010-12-02
申请号:US12743143
申请日:2008-11-03
申请人: Rebekah J. Carson , Lee Fader , Stephen Kawai , Serge R. Landry , Youla S. Tsantrizos , Christian Brochu , Sebastien Morin , Mathieu Parisien , Bruno Simoneau
发明人: Rebekah J. Carson , Lee Fader , Stephen Kawai , Serge R. Landry , Youla S. Tsantrizos , Christian Brochu , Sebastien Morin , Mathieu Parisien , Bruno Simoneau
IPC分类号: A61K31/538 , C07D495/04 , A61K31/4365 , C07D491/06 , A61K31/436 , A61P31/18
CPC分类号: C07D495/04 , C07D519/00
摘要: The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection
摘要翻译: 本发明涉及其中c,X,Y,R 2,R 3,R 4和R 6如本文所定义的式(I)化合物,其用于治疗人类免疫缺陷病毒(HIV)感染的组合物和用途。 特别地,本发明提供HIV整合酶的新型抑制剂,含有这些化合物的药物组合物和使用这些化合物治疗HIV感染的方法
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公开(公告)号:USD549158S1
公开(公告)日:2007-08-21
申请号:US29258273
申请日:2006-04-19
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