公开(公告)号：US06617118B2

公开(公告)日：2003-09-09

申请号：US09810379

申请日：2001-03-16

Applicant: Steve Roffler ,  Tian-Lu Cheng ,  Pin-Yi Wu

Inventor： Steve Roffler ,  Tian-Lu Cheng ,  Pin-Yi Wu

IPC: G01N3353

CPC classification number: G01N33/5308 ,  A61K2039/505 ,  C07K16/44 ,  G01N2430/60

Abstract: A novel anti-polyethylene glycol monoclonal antibody and its preparation are disclosed. Such an antibody can be used for determining polyethylene glycol concentration in vitro or accelerating the clearance of a polyethylene glycol containing compound from the blood circulation in the human body thereby reducing the toxicity associated with the polyethylene glycol containing conjugate. The antibody is particularly useful in cancer therapy where the therapeutic agent is selectively delivered to the tumor by increasing the tumor/blood ratio of the polyethylene glycol containing compound.

Abstract translation: 公开了一种新的抗聚乙二醇单克隆抗体及其制备方法。 这样的抗体可以用于体外测定聚乙二醇浓度，或加速来自人体血液循环的含聚乙二醇的化合物的清除，从而降低与含聚乙二醇的缀合物相关的毒性。 抗体特别可用于癌症治疗，其中治疗剂通过增加含聚乙二醇的化合物的肿瘤/血液比选择性递送至肿瘤。