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公开(公告)号:US07579363B2
公开(公告)日:2009-08-25
申请号:US11769679
申请日:2007-06-27
申请人: Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
发明人: Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
IPC分类号: C07D417/12 , C07D279/16 , A61K31/5415
CPC分类号: C07D279/16 , C07D215/227 , C07D417/06 , C07D417/12
摘要: This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.
摘要翻译: 本发明涉及新颖的双环化合物,涉及这些化合物在各种医学应用中的用途,包括治疗适合于通过肽基变性酶抑制剂治疗的疾病,例如治疗细菌感染,以及包含这些化合物的药物组合物。
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12.
公开(公告)号:US07563894B2
公开(公告)日:2009-07-21
申请号:US11932945
申请日:2007-10-31
申请人: Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
发明人: Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
IPC分类号: C07D403/10 , C07D403/14 , C07D239/42 , A61K31/505
CPC分类号: C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
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13.
公开(公告)号:US20080167308A1
公开(公告)日:2008-07-10
申请号:US11932945
申请日:2007-10-31
申请人: Valentina Molteni , Xiaolin Li , Donatella Chianelli , Juliet Nabakka , Jon Loren , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
发明人: Valentina Molteni , Xiaolin Li , Donatella Chianelli , Juliet Nabakka , Jon Loren , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
IPC分类号: A61K31/5377 , C07D239/42 , A61K31/505 , A61K31/506 , C12N9/12 , C07D403/12 , C07D413/12
CPC分类号: C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
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公开(公告)号:US20070293547A1
公开(公告)日:2007-12-20
申请号:US10589410
申请日:2005-02-11
申请人: Valentina Molteni , Xiaolin Li , Fang Liang , Juliet Nabakka , Enrique Saez , John Wityak
发明人: Valentina Molteni , Xiaolin Li , Fang Liang , Juliet Nabakka , Enrique Saez , John Wityak
IPC分类号: A61K31/44 , A61K31/16 , A61K31/335 , C07D215/00 , C07D307/02 , C07D231/00 , C07D211/72 , A61K31/34
CPC分类号: C07C233/83 , C07C237/38 , C07C237/42 , C07C239/20 , C07C255/29 , C07C255/54 , C07C255/60 , C07C271/28 , C07C311/08 , C07C317/22 , C07C323/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D239/26
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与肝脏X受体(LXR)活性相关的疾病或病症的方法。
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公开(公告)号:US20150175613A1
公开(公告)日:2015-06-25
申请号:US14574775
申请日:2014-12-18
申请人: Agnes BIGGART , Fang LIANG , Casey Jacob Nelson MATHISON , Valentina MOLTENI , Advait Suresh NAGLE , Frantisek SUPEK , Vince YEH
发明人: Agnes BIGGART , Fang LIANG , Casey Jacob Nelson MATHISON , Valentina MOLTENI , Advait Suresh NAGLE , Frantisek SUPEK , Vince YEH
IPC分类号: C07D487/04 , C07F5/02 , C07D519/00 , C07F7/08
CPC分类号: A61K31/519 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D487/04 , C07D519/00 , C07F5/027 , C07F7/0814
摘要: The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.
摘要翻译: 本发明提供式A化合物或其药学上可接受的盐,互变异构体或立体异构体,其中变量如本文所定义。 本发明还提供了包含这些化合物的药物组合物和使用这些化合物治疗,预防,抑制,改善或消除由寄生虫引起的疾病的病理和/或症状的方法,例如利什曼病,人非洲锥虫病和查加斯 疾病。
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公开(公告)号:US09023839B2
公开(公告)日:2015-05-05
申请号:US14258963
申请日:2014-04-22
申请人: Valentina Molteni , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
发明人: Valentina Molteni , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
IPC分类号: C07D498/04 , C07D471/04 , C07D491/044 , C07D491/107 , C07D491/048
CPC分类号: C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
摘要: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译: 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物,以及使用这些化合物治疗,改善或预防与异常或失调激酶活性相关的病症的方法。 在一些实施方案中,本发明提供了使用这些化合物治疗,改善或预防涉及c-kit或c-kit和PDGFR(PDGFRα,PDGFR&bgr))激酶的异常活化的疾病或病症的方法。
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公开(公告)号:US20140275013A1
公开(公告)日:2014-09-18
申请号:US14209536
申请日:2014-03-13
申请人: Arnab Kumar CHATTERJEE , Fang LIANG , Casey Jacob Nelson MATHISON , Pranab Kumar MISHRA , Valentina MOLTENI , Advait Suresh Nagle , Frantisek SUPEK , Liying Jocelyn TAN , Agnes VIDAL , Michael Herman GELB , Frederick Simmons BUCKNER , Hari Babu TATIPAKA , Neil Richard NORCROSS , John Robert GILLESPIE
发明人: Arnab Kumar CHATTERJEE , Fang LIANG , Casey Jacob Nelson MATHISON , Pranab Kumar MISHRA , Valentina MOLTENI , Advait Suresh Nagle , Frantisek SUPEK , Liying Jocelyn TAN , Agnes VIDAL , Michael Herman GELB , Frederick Simmons BUCKNER , Hari Babu TATIPAKA , Neil Richard NORCROSS , John Robert GILLESPIE
IPC分类号: C07D473/00 , C07D471/04
CPC分类号: C07D473/00 , C07D471/04 , C07D487/04 , C07D498/04
摘要: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.
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公开(公告)号:US08569345B2
公开(公告)日:2013-10-29
申请号:US13414385
申请日:2012-03-07
申请人: Valentina Molteni , Xiaolin Li , Juliet Nabakka , David Archer Ellis , Beth Anaclerio , Enrique Saez , John Wityak
发明人: Valentina Molteni , Xiaolin Li , Juliet Nabakka , David Archer Ellis , Beth Anaclerio , Enrique Saez , John Wityak
IPC分类号: A61K31/4439 , A61K31/433 , C07D417/04 , C07D417/14
CPC分类号: C07D285/12 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与肝脏X受体(LXR)活性相关的疾病或病症的方法。
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公开(公告)号:US08569283B2
公开(公告)日:2013-10-29
申请号:US13598213
申请日:2012-08-29
申请人: Valentina Molteni , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
发明人: Valentina Molteni , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
IPC分类号: A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61P1/00 , A61P1/16 , A61P3/00 , A61P3/10 , A61P7/00 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P29/00 , A61P37/00 , A61P37/08 , C07D471/04 , C07D491/048 , C07D491/107
CPC分类号: C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
摘要: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译: 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物,以及使用这些化合物治疗,改善或预防与异常或失调激酶活性相关的病症的方法。 在一些实施方案中,本发明提供了使用这些化合物治疗,改善或预防涉及c-kit或c-kit和PDGFR(PDGFRα,PDGFRβ)激酶异常活化的疾病或病症的方法。
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公开(公告)号:US20130237519A1
公开(公告)日:2013-09-12
申请号:US13599267
申请日:2012-08-30
申请人: Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
发明人: Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
IPC分类号: C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/5377 , A61K31/496
CPC分类号: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要: Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.
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