公开(公告)号：US08420836B2

公开(公告)日：2013-04-16

申请号：US13124521

申请日：2009-10-21

Applicant: Mitsuyoshi Sakasai ,  Yusuke Shibuya ,  Azumi Nagasawa

Inventor： Mitsuyoshi Sakasai ,  Yusuke Shibuya ,  Azumi Nagasawa

IPC: C07D493/00

CPC classification number: A61K31/352 ,  A61K8/498 ,  A61Q7/00 ,  C07D493/04

Abstract: An NFAT signal inhibitor and the like are provided.An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where in the formula (I), R1 and R2, which may be identical with or different from each other, each represent a hydrogen atom or a group represented by formula (II) (where in the formula (II), R3 represents a linear or branched alkyl or alkenyl group having 1 to 20 carbon atoms)] and pharmacologically acceptable salts thereof.

Abstract translation: 提供NFAT信号抑制剂等。 NFAT信号抑制剂等含有作为有效成分的至少一种选自由式[I]表示的香豆素衍生物的化合物，其中R1和R2可以相同或不同， 各自表示氢原子或式（II）表示的基团（式（II）中，R3表示碳原子数1〜20的直链或支链烷基或烯基）]和药理学上可接受的盐 其中。

公开(公告)号：US20110263695A1

公开(公告)日：2011-10-27

申请号：US13124521

申请日：2009-10-21

Applicant: Mitsuyoshi Sakasai ,  Yusuke Shibuya ,  Azumi Nagasawa

Inventor： Mitsuyoshi Sakasai ,  Yusuke Shibuya ,  Azumi Nagasawa

IPC: A61K31/37 ,  A61P17/14 ,  C07D493/04

CPC classification number: A61K31/352 ,  A61K8/498 ,  A61Q7/00 ,  C07D493/04

Abstract: An NFAT signal inhibitor and the like are provided.An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where in the formula (I), R1 and R2, which may be identical with or different from each other, each represent a hydrogen atom or a group represented by formula (II) (where in the formula (II), R3 represents a linear or branched alkyl or alkenyl group having 1 to 20 carbon atoms)] and pharmacologically acceptable salts thereof.

Abstract translation: 提供NFAT信号抑制剂等。 NFAT信号抑制剂等含有作为有效成分的至少一种选自由式[I]表示的香豆素衍生物的化合物，其中R1和R2可以相同或不同， 各自表示氢原子或式（II）表示的基团（式（II）中，R3表示碳原子数1〜20的直链或支链烷基或烯基）]和药理学上可接受的盐 其中。