PEGYLATED CYCLOPAMINE ANALOGUE, PREPARATION METHOD AND USES THEREOF
    11.
    发明申请
    PEGYLATED CYCLOPAMINE ANALOGUE, PREPARATION METHOD AND USES THEREOF 有权
    聚乙二醇化合物类似物,其制备方法及其用途

    公开(公告)号:US20130324569A1

    公开(公告)日:2013-12-05

    申请号:US13882797

    申请日:2011-02-25

    IPC分类号: A61K47/48

    摘要: A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.

    摘要翻译: 公开了聚乙二醇化的环巴胺类似物,其制备方法,其用途和使用其的治疗增殖性疾病的方法。 聚乙二醇化环胺类似物是由下式I表示的化合物,包含至少一个由下式I表示的基团的化合物(在式I中,R是分子量为200至200,000道尔顿的直链或支链聚乙二醇,L 和X是连接基团)或其单一对映异构体,对映异构体的混合物,非对映异构体的混合物,药学上可接受的盐,溶剂合物或水合物。