公开(公告)号：US20210292438A1

公开(公告)日：2021-09-23

申请号：US17340102

申请日：2021-06-07

Applicant: ACADEMIA SINICA

Inventor： Steve ROFFLER ,  Tian-Lu Cheng ,  Yu-Cheng Su ,  Kuo-Hsiang Chuang

IPC: C07K16/44 ,  A61K47/60 ,  A61K47/69 ,  A61P35/00 ,  A61K31/55 ,  A61K31/704 ,  A61K51/06 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  G01N33/574

Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also disclosed is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. Further disclosed is a method for diagnosing a cell-mediated disorder by administering a PEG engager followed by a PEGylated diagnostic agent.