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公开(公告)号：US20220389119A1
公开(公告)日：2022-12-08
申请号：US17775063
申请日：2020-11-06
Applicant: AMGEN INC.
Inventor： Bram ESTES , Fernando GARCES , Zhulun WANG , Mark DARIS
IPC: C07K16/46
Abstract: The present invention relates to heterodimers comprising antibody CH3 domains and mutations useful for the facilitation of the formation of heterodimers. Methods of optimizing purification of the heterodimers at certain pHs in also disclosed.
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