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公开(公告)号：US10752694B2
公开(公告)日：2020-08-25
申请号：US14776649
申请日：2014-03-14
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , C07K14/705 , C07K14/715 , C07K14/725 , A61K39/00
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of the binding molecule and a kit comprising the binding molecule.
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公开(公告)号：US20160176973A1
公开(公告)日：2016-06-23
申请号：US14776649
申请日：2014-03-14
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/28
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：US09340621B2
公开(公告)日：2016-05-17
申请号：US13678247
申请日：2012-11-15
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , C07K14/705 , A61K39/00
CPC分类号： C07K16/468 , A61K39/0005 , A61K2039/505 , A61K2039/575 , C07K14/70578 , C07K16/2809 , C07K16/2875 , C07K16/2878 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/43
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
摘要翻译： 本发明涉及至少双特异性的包含第一和第二结合结构域的结合分子，其中第一结合结构域能够与BCMA的表位簇3结合，并且第二结合结构域能够结合T 细胞CD3受体复合物。 此外，本发明提供编码结合分子的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的结合分子的方法，所述结合分子的医学用途和包含所述结合分子的试剂盒。
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公开(公告)号：US09150664B2
公开(公告)日：2015-10-06
申请号：US13678264
申请日：2012-11-15
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/28 , C07K16/46 , C07K14/575 , A61K39/395 , C07K14/705 , A61K39/00
CPC分类号： C07K16/468 , A61K39/0005 , A61K2039/505 , A61K2039/575 , C07K14/70578 , C07K16/2809 , C07K16/2875 , C07K16/2878 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/43
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
摘要翻译： 本发明涉及包含第一和第二结合结构域的结合分子，其中第一结合结构域能够结合BCMA的表位簇，并且第二结合结构域能够结合T细胞CD3受体复合物。 此外，本发明提供编码结合分子的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的结合分子的方法，所述结合分子的医学用途和包含所述结合分子的试剂盒。
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公开(公告)号：US20150037334A1
公开(公告)日：2015-02-05
申请号：US14381902
申请日：2013-03-01
发明人： Peter Kufer , Tobias Raum , Ralf Lutterbuese , Patrick Hoffmann , Markus Muenz , Johannes Brozy , Majk Kvesic
CPC分类号： C07K16/2809 , C07K16/26 , C07K16/30 , C07K16/3069 , C07K2317/31 , C07K2317/34 , C07K2317/569 , C07K2317/622 , C07K2317/732 , C07K2317/92 , C07K2319/30 , C07K2319/31 , C07K2319/32
摘要： The present invention relates to a binding molecule comprising at least three domains comprised in at least one polypeptide chain, wherein the first binding domain is a binding domain which is capable of binding to a cell surface molecule on a target cell, the second binding domain is a binding domain which is capable of binding to the T cell CD3 receptor complex, and the third domain is a binding domain which is capable of binding to serum albumin, wherein said third domain is positioned at the C-terminus of said second domain. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
摘要翻译： 本发明涉及包含至少三个结构域的结合分子，所述至少三个结构域包含在至少一个多肽链中，其中第一结合结构域是能够结合靶细胞上的细胞表面分子的结合结构域，第二结合结构域是 能够结合T细胞CD3受体复合物的结合结构域，第三结构域是能够结合血清白蛋白的结合结构域，其中所述第三结构域位于所述第二结构域的C末端。 此外，本发明提供编码结合分子的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的结合分子的方法，所述结合分子的医学用途和包含所述结合分子的试剂盒。
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公开(公告)号：US20220064336A1
公开(公告)日：2022-03-03
申请号：US17011849
申请日：2020-09-03
申请人： Amgen Inc.
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/46 , C07K14/705 , C07K16/28 , A61K39/00
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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