公开(公告)号：US09714231B2

公开(公告)日：2017-07-25

申请号：US14442642

申请日：2013-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bruce A. Ellsworth ,  Elizabeth A. Jurica ,  Jun Shi ,  William R. Ewing ,  Xiang-Yang Ye ,  Ximao Wu ,  Zhu Yeheng ,  Sun Chongqing

IPC: A61K31/4025 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/506 ,  C07D401/12 ,  C07D401/14 ,  C07D487/04 ,  A61K45/06 ,  C07D207/08 ,  C07D207/12 ,  C07D401/10

CPC classification number: C07D401/12 ,  A61K31/4025 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/506 ,  A61K45/06 ,  C07D207/08 ,  C07D207/12 ,  C07D401/10 ,  C07D401/14 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US20170081282A1

公开(公告)日：2017-03-23

申请号：US15308459

申请日：2015-05-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiang-Yang Ye ,  Bruce A. Ellsworth ,  Elizabeth A. Jurica

IPC: C07D207/08 ,  A61K31/40 ,  C07D207/16 ,  A61K31/422 ,  C07D401/04 ,  A61K31/4439 ,  C07D413/04 ,  A61K45/06 ,  C07D207/12

CPC classification number: C07D207/08 ,  A61K31/40 ,  A61K31/422 ,  A61K31/4439 ,  A61K45/06 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D401/04 ,  C07D413/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.