公开(公告)号：US20200299392A1

公开(公告)日：2020-09-24

申请号：US16808910

申请日：2020-03-04

Applicant: Five Prime Therapeutics, Inc. ,  Bristol-Myers Squibb Company

Inventor： Brian Wong ,  Julie Hambleton ,  Robert Sikorski ,  Emma Masteller ,  Kevin Hestir ,  David Bellovin ,  Katherine E. Lewis

IPC: C07K16/28 ,  C07K16/30

Abstract: Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.

公开(公告)号：US10081681B2

公开(公告)日：2018-09-25

申请号：US15021102

申请日：2014-09-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alan J. Korman ,  Nils Lonberg ,  David J. Fontana ,  Andres A. Gutierrez ,  Mark J. Selby ,  Katherine E. Lewis

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/2818 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/54 ,  A61K2039/545 ,  A61P35/00 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/94

Abstract: Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-LAG-3 antibody in combination with an anti-PD-1 antibody.

公开(公告)号：US10221244B2

公开(公告)日：2019-03-05

申请号：US15680664

申请日：2017-08-18

Applicant: Five Prime Therapeutics, Inc. ,  Bristol-Myers Squibb Company

Inventor： Brian Wong ,  Julie Hambleton ,  Robert Sikorski ,  Emma Masteller ,  Kevin Hestir ,  David Bellovin ,  Katherine E. Lewis

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00

Abstract: Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.