公开(公告)号：US20150018347A1

公开(公告)日：2015-01-15

申请号：US14503456

申请日：2014-10-01

Applicant: Bristol-Myers Squibb Company

Inventor： T. G. Murali Dhar ,  John V. Duncia ,  Daniel S. Gardner ,  Weiwei Guo ,  John Hynes

IPC: C07D471/10 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

CPC classification number: C07D471/10 ,  A61K31/4427 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04

Abstract: The present application describes modulators of chemokine receptor activity of formula I or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.

Abstract translation: 本申请描述了式I的趋化因子受体活性的调节剂或其立体异构体或其药学上可接受的盐。 此外，公开了使用式（I）的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和移植排斥反应的自身免疫病态的方法。