公开(公告)号：US20150344553A1

公开(公告)日：2015-12-03

申请号：US14654176

申请日：2013-12-20

Applicant: BIOGEN MA INC. ,  BIOGEN IDEC INTERNATIOANL NEUROSCIENCE GMBH

Inventor： Paul H. Weinreb ,  Feng Chen ,  Ellen A. Garber ,  Jan Grimm ,  Fable Montrasio

IPC: C07K16/18 ,  G01N33/68 ,  A61K49/00 ,  A61K49/16 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K49/00 ,  A61K49/16 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2800/2814

Abstract: Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.