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    MULTIMODAL IMAGING METHOD USING NANO-EMULSION COMPRISING OPTICAL NANO-PARTICLES AND PERFLUOROCARBONS
    11.
    发明申请
    MULTIMODAL IMAGING METHOD USING NANO-EMULSION COMPRISING OPTICAL NANO-PARTICLES AND PERFLUOROCARBONS 有权
    使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法

    公开(公告)号：US20110110867A1

    公开(公告)日：2011-05-12

    申请号：US13000197

    申请日：2009-06-19

    申请人： Bong Hyun Chung ,  Yong Taik Lim

    发明人： Bong Hyun Chung ,  Yong Taik Lim

    IPC分类号： A61K49/06 ,  A61K49/00 ,  B82Y15/00

    CPC分类号： A61K49/0078 ,  A61K49/0002 ,  A61K49/0017 ,  A61K49/0067 ,  A61K49/1806

    摘要： The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varying the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.

    摘要翻译： 本发明涉及使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法，更具体地说，涉及使用由全氟化碳组成的纳米乳液用于多光谱磁共振成像（MRI）和 用于多色荧光检测的纳米颗粒。 在多模式成像方法中，通过改变全氟化碳的种类和组合以及光学纳米颗粒的种类和组合，可以获得各种多光谱MRI图像和多色荧光光谱，从而可以进行多重分析。 因此，多模式成像方法可以应用于已经进行细胞分子成像研究的生物和医学领域的各个领域。

    Multimodal imaging method using nano-emulsion comprising optical nano-particles and perfluorocarbons
    13.
    发明授权
    Multimodal imaging method using nano-emulsion comprising optical nano-particles and perfluorocarbons 有权
    使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法

    公开(公告)号：US08753606B2

    公开(公告)日：2014-06-17

    申请号：US13000197

    申请日：2009-06-19

    申请人： Bong Hyun Chung ,  Yong Taik Lim

    发明人： Bong Hyun Chung ,  Yong Taik Lim

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0078 ,  A61K49/0002 ,  A61K49/0017 ,  A61K49/0067 ,  A61K49/1806

    摘要： The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varying the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.

    摘要翻译： 本发明涉及使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法，更具体地说，涉及使用由全氟化碳组成的纳米乳液用于多光谱磁共振成像（MRI）和 用于多色荧光检测的纳米颗粒。 在多模式成像方法中，通过改变全氟化碳的种类和组合以及光学纳米颗粒的种类和组合，可以获得各种多光谱MRI图像和多色荧光光谱，从而可以进行多重分析。 因此，多模式成像方法可以应用于已经进行细胞分子成像研究的生物和医学领域的各个领域。

    COSMETIC PIGMENT COMPOSITION CONTAINING GOLD OR SILVER NANO-PARTICLES
    14.
    发明申请
    COSMETIC PIGMENT COMPOSITION CONTAINING GOLD OR SILVER NANO-PARTICLES 审中-公开
    包含金或银纳米颗粒的化妆品颜料组合物

    公开(公告)号：US20090022765A1

    公开(公告)日：2009-01-22

    申请号：US11995847

    申请日：2006-02-13

    申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Jin Kyeong Kim ,  Jin Young Jeong ,  Tai Hwan Ha

    发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Jin Kyeong Kim ,  Jin Young Jeong ,  Tai Hwan Ha

    IPC分类号： A61K8/19 ,  A61K8/00 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/10

    CPC分类号： B82Y5/00 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/8176 ,  A61K2800/413 ,  A61Q1/02 ,  A61Q1/06

    摘要： The present invention relates to a cosmetic pigment composition exhibiting colors in the visible region, which comprises an effective amount of nanoparticles or a mixture of two or more nanoparticles selected from the group consisting of (a) gold nanoparticles exhibiting red color; (b) silver nanoparticles exhibiting yellow color; (c) gold-silver alloy nanoparticles exhibiting flame color; and (d) gold nanoparticles exhibiting blue color, and a color cosmetic composition and a color lotion comprising the pigment composition. According to the present invention, it is possible to prepare pigments exhibiting various colors in the visible region using gold or silver nanoparticles, and a cosmetic pigment composition which can exhibit various colors by mixing the pigments in various compositional ratios, in which precipitation or agglomeration of particles does not occur, and whose color can be maintained for a long time. Also, since the pigment of the present invention is not harmful to the human body unlike conventional metal pigments, and contains gold or silver that is beneficial to health, the pigment can be used in various applications as functional raw materials.

    摘要翻译： 本发明涉及一种在可见光区域显示颜色的化妆品颜料组合物，其包含有效量的纳米颗粒或选自（a）显示红色的金纳米颗粒的两种或更多种纳米颗粒的混合物; （b）呈现黄色的银纳米颗粒; （c）显示火焰色的金 - 银合金纳米颗粒; 和（d）显示蓝色的金纳米颗粒，以及着色化妆品组合物和包含该颜料组合物的色乳液。 根据本发明，可以使用金或银纳米颗粒制备在可见区域中显示各种颜色的颜料，以及可以通过以各种组成比混合颜料来显示各种颜色的化妆品颜料组合物，其中沉淀或聚集 颗粒不会发生，并且其颜色可以长时间保持。 此外，由于本发明的颜料与常规金属颜料不同，对人体无害，并且含有有益于健康的金或银，所以颜料可用作各种用途的功能性原料。

    Coenzyme Q10 nanoparticles, preparation method thereof and composition containing said nanoparticles
    16.
    发明授权
    Coenzyme Q10 nanoparticles, preparation method thereof and composition containing said nanoparticles 失效
    辅酶Q10纳米颗粒，其制备方法和含有所述纳米颗粒的组合物

    公开(公告)号：US08785598B2

    公开(公告)日：2014-07-22

    申请号：US13263296

    申请日：2010-04-06

    申请人： Bong Hyun Chung ,  Jung Hyun Han

    发明人： Bong Hyun Chung ,  Jung Hyun Han

    IPC分类号： C07K14/00

    CPC分类号： A61K31/122 ,  A23L33/15 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/127 ,  A61K9/145 ,  A61K9/146 ,  A61K47/10 ,  A23V2250/314

    摘要： Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, Coenzyme Q10 may be dissolved in only a water-miscible organic solvent, and easily made into a nano-sized particle and solubilized under a low energy condition, for example, by simple stirring. The coenzyme Q10 may be dispersion-stabilized by an amino acid or protein. The coenzyme Q10 is formed in a nano-sized particle and solubilized, an absorption rate may be increased and simultaneously deliver the amino acid and protein with the nanoparticle. Thus, the coenzyme Q10 nanoparticle can be effectively used in food, cosmetics and medicine.

    摘要翻译： 提供了辅酶Q10纳米颗粒，其制备方法和具有纳米颗粒的组合物。 根据本发明，辅酶Q10可以仅溶解在水混溶性有机溶剂中，并且容易地制成纳米尺寸的颗粒并在低能量条件下溶解，例如通过简单搅拌。 辅酶Q10可以通过氨基酸或蛋白质进行分散稳定化。 辅酶Q10在纳米尺寸的颗粒中形成并溶解，可以增加吸收速率并同时与纳米颗粒递送氨基酸和蛋白质。 因此，辅酶Q10纳米颗粒可以有效地用于食品，化妆品和医药。

    Asymmetric Liposomes for the Highly Efficient Encapsulation of Nucleic Acids and Hydrophilic Anionic Compounds, and Method for Preparing Same
    18.
    发明申请
    Asymmetric Liposomes for the Highly Efficient Encapsulation of Nucleic Acids and Hydrophilic Anionic Compounds, and Method for Preparing Same 有权
    用于高效包封核酸和亲水阴离子化合物的不对称脂质体及其制备方法

    公开(公告)号：US20130149374A1

    公开(公告)日：2013-06-13

    申请号：US13697705

    申请日：2010-11-12

    申请人： Myung Kyu Lee ,  Abbas Mokhtarieh Amir ,  Bong Hyun Chung ,  Jong Min Choi

    发明人： Myung Kyu Lee ,  Abbas Mokhtarieh Amir ,  Bong Hyun Chung ,  Jong Min Choi

    IPC分类号： A61K9/127 ,  A61K31/713

    CPC分类号： A61K9/1272 ,  A61K9/1271 ,  A61K9/1277 ,  A61K31/122 ,  A61K31/70 ,  A61K31/713

    摘要： The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.

    摘要翻译： 本发明涉及用于核酸和亲水性阴离子化合物的高包封效率的不对称脂质体及其制备方法，具体涉及由具有小头基团作为内部脂质和中性的阳离子脂质组成的不对称脂质体 或具有大头基的聚乙二醇化脂质作为外部脂质，其中核酸和/或阴离子化合物包封在内部脂质中。 根据本发明，可以制备其中核酸和亲水性阴离子化合物以高效率包封的不对称脂质体，因此可以用于各种目的，例如基因治疗和递送亲水性阴离子药物 其难以作为前药制备，并且药物递送，成像等可以通过将荧光对比剂包封在脂质体中来进行。

    Reversible Fluorescence Photoswitch based on Dye-Crosslinked Dendritic Nanoclusters for High-Contrast Imaging of Living Biological Systems
    19.
    发明申请
    Reversible Fluorescence Photoswitch based on Dye-Crosslinked Dendritic Nanoclusters for High-Contrast Imaging of Living Biological Systems 有权
    基于染料交联树枝状纳米团簇的可逆荧光光电开关，用于生物生物系统的高对比度成像

    公开(公告)号：US20120220734A1

    公开(公告)日：2012-08-30

    申请号：US13218608

    申请日：2011-08-26

    申请人： Yoonkyung Kim ,  Hye-Youn Jung ,  Bong Hyun Chung

    发明人： Yoonkyung Kim ,  Hye-Youn Jung ,  Bong Hyun Chung

    IPC分类号： C09B69/10 ,  B82Y5/00 ,  B82Y15/00

    CPC分类号： B82Y15/00 ,  C09B69/00

    摘要： The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.

    摘要翻译： 本发明涉及一种基于染料交联树枝状纳米团簇的可逆荧光光电开关，用于生物体系的高对比度成像。 根据本发明的树枝状纳米团簇由两个或更多个交联的树枝状聚合物组成，从而整体上具有球状，从而提高荧光强度并提高单体树枝状大分子的检测灵敏度。 此外，发现根据本发明的树突状纳米簇独立地通过皮肤渗透和显微注射而内在化为活的斑马鱼。 此外，根据本发明的树突状纳米簇显示低毒性，因此其可用于体内和体外成像以及离体细胞追踪应用。

    High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby
    20.
    发明申请
    High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby 审中-公开
    通过筛选caspase3和XIAP结合抑制剂之间的结合抑制剂的高通量筛选方法

    公开(公告)号：US20090318376A1

    公开(公告)日：2009-12-24

    申请号：US12304766

    申请日：2006-06-12

    申请人： Bong Hyun Chung ,  Kwang-Hee Son ,  Moonil Kim ,  Kyoungsook Park ,  Byoung-Mog Kwon ,  Hyun Jung Junn ,  Dong Cho Han ,  Sun-Hee Jeon

    发明人： Bong Hyun Chung ,  Kwang-Hee Son ,  Moonil Kim ,  Kyoungsook Park ,  Byoung-Mog Kwon ,  Hyun Jung Junn ,  Dong Cho Han ,  Sun-Hee Jeon

    IPC分类号： A61K31/702 ,  G01N33/573 ,  C07H15/24

    CPC分类号： A61K31/702 ,  G01N33/574 ,  G01N2333/96469 ,  G01N2500/02

    摘要： The present invention relates to a high throughput screening method of a binding inhibitor between caspase3 and xIAP and chromomycin screened using the same, and more specifically, the present invention provides a method for screening anticancer substance, the method comprising the steps of reacting caspase3 or xIAP and candidate inhibitors of the binding between caspase3 and xIAP on a biochip for detecting caspase3:xIAP interaction, and selecting a candidate substance inhibiting the binding of caspase3 to xIAP as an anticancer substance, and an anticancer agent inhibiting caspase3:xIAP binding, which is screened by the above method. According to present invention, it is possible to develop a target-oriented anticancer agent focused on xIAP and caspase3, apoptosis-related proteins and thus it can be applied to tailored medication and combination therapy. Moreover, glycoside antibiotic chromomycin, screened by the present invention has inhibitory activity of the binding between xIAP and caspase3 involved in apoptosis, so that it can be used as a therapeutic agent for myelogenous leukemia and solid tumors.

    摘要翻译： 本发明涉及使用其筛选的胱天蛋白酶3和xIAP之间的结合抑制剂的高通量筛选方法，更具体地说，本发明提供了筛选抗癌物质的方法，所述方法包括以下步骤：使半胱天冬酶3或xIAP 以及用于检测胱天蛋白酶3：xIAP相互作用的生物芯片上的半胱天冬酶3和xIAP之间的结合的候选抑制剂，并且选择抑制半胱天冬酶3与作为抗癌物质的xIAP的结合的候选物质，以及抑制胱天蛋白酶3的抗癌剂：xIAP结合 通过上述方法。 根据本发明，可以开发聚焦于xIAP和caspase3的靶向抗癌剂，凋亡相关蛋白，因此可以应用于定制药物和联合治疗。 此外，通过本发明筛选的糖苷抗生素chromomycin具有抑制参与凋亡的xIAP和半胱天冬酶3之间的结合的活性，因此可以用作骨髓性白血病和实体瘤的治疗剂。