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公开(公告)号：US20060019357A1
公开(公告)日：2006-01-26
申请号：US11197380
申请日：2005-08-05
申请人： Bettina Moeckel , Brigitte Bathe , Stefan Hans , Caroline Kreutzer , Thomas Hermann , Walter Pfefferle , Michael Binder
发明人： Bettina Moeckel , Brigitte Bathe , Stefan Hans , Caroline Kreutzer , Thomas Hermann , Walter Pfefferle , Michael Binder
CPC分类号： C07K14/34
摘要： An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
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公开(公告)号：US06939695B2
公开(公告)日：2005-09-06
申请号：US10075460
申请日：2002-02-15
申请人： Bettina Moeckel , Brigitte Bathe , Stefan Hans , Caroline Kreutzer , Thomas Hermann , Walter Pfefferle , Michael Binder
发明人： Bettina Moeckel , Brigitte Bathe , Stefan Hans , Caroline Kreutzer , Thomas Hermann , Walter Pfefferle , Michael Binder
CPC分类号： C07K14/34
摘要： An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸，b） 编码多肽的多核苷酸，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸， 和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少存在rpsL基因 增强形式，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。
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13.发明授权Polynucleotides encoding the nadA gene and methods of producing nicotinic acid or nicotinic acid derivatives 失效编码nadA基因的多核苷酸和产生烟酸或烟酸衍生物的方法公开(公告)号：US06692946B2
公开(公告)日：2004-02-17
申请号：US09789599
申请日：2001-02-22
IPC分类号： C12N904
摘要： The present invention relates to polynucleotides corresponding to the nadA gene and which encode the quinolinate synthetase A protein, methods of producing nicotinic acid or nicotinic acid derivatives, and methods of screening for polynucleotides which encode proteins having quinolinate synthetase A activity.
摘要翻译： 本发明涉及对应于nadA基因并编码喹啉酸合成酶A蛋白质的多核苷酸，产生烟酸或烟酸衍生物的方法，以及筛选编码具有喹啉酸合成酶A活性的蛋白质的多核苷酸的方法。
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14.发明授权Polynucleotides encoding the nadC gene and methods of producing nicotinic acid or nicotinic acid derivatives 失效编码nadC基因的多核苷酸和产生烟酸或烟酸衍生物的方法公开(公告)号：US06689587B2
公开(公告)日：2004-02-10
申请号：US09789582
申请日：2001-02-22
IPC分类号： C12P1712
CPC分类号： C12P17/12 , C12N9/1077
摘要： The present invention relates to polynucleotides corresponding to the nadC gene and which encode the nicotinate nucleotide pyrophosphorylase protein, methods of producing nicotinic acid or nicotinic acid derivatives, and methods of screening for polynucleotides which encode proteins having nicotinate nucleotide pyrophosphorylase activity.
摘要翻译： 本发明涉及对应于nadC基因并编码烟酸核苷酸焦磷酸化酶蛋白质的多核苷酸，产生烟酸或烟酸衍生物的方法，以及筛选编码具有烟酸核苷酸焦磷酸化酶活性的蛋白质的多核苷酸的方法。
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公开(公告)号：US06777206B2
公开(公告)日：2004-08-17
申请号：US09950071
申请日：2001-09-12
IPC分类号： C12P2106
摘要： The invention provides nucleotide sequences from Coryneform bacteria which code for the RodA protein and a process for the fermentative preparation of amino acids using bacteria in which the rodA gene is enhanced.
摘要翻译： 本发明提供了编码RodA蛋白质的棒状细菌的核苷酸序列和使用其中rodA基因增强的细菌发酵制备氨基酸的方法。
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公开(公告)号：US07129066B2
公开(公告)日：2006-10-31
申请号：US10375355
申请日：2003-02-28
申请人： Mike Farwick , Klaus Huthmacher , Achim Marx , Brigitte Bathe , Walter Pfefferle
发明人： Mike Farwick , Klaus Huthmacher , Achim Marx , Brigitte Bathe , Walter Pfefferle
CPC分类号： C12Y401/03006 , C12N9/88
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing the amino acid sequence of SEQ ID No. 2, b) polynucleotide that codes for a polypeptide containing an amino acid sequence that is at least 70% identical with the amino acid sequence of SEQ ID No. 2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b) or c), and to a process for the production of L-amino acids by fermentation using coryneform bacteria in which at least the citE gene is present in attenuated form, and to the use of polynucleotides containing the sequences of the invention as hybridization probes.
摘要翻译： 本发明涉及含有多核苷酸序列的多核苷酸序列，该多核苷酸序列选自a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 对于含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少含有 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及通过发酵使用其中至少有citE基因以减毒形式存在的棒状细菌产生L-氨基酸的方法， 使用含有本发明序列的多核苷酸作为杂交探针。
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公开(公告)号：US20060177912A1
公开(公告)日：2006-08-10
申请号：US11274317
申请日：2005-11-16
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the dep34 gene, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
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公开(公告)号：US07029904B2
公开(公告)日：2006-04-18
申请号：US09946763
申请日：2001-09-06
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which codes for the dep34 efflux protein, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID NO: 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译： 本发明涉及具有编码dep34流出蛋白的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中dep34基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带至少 根据SEQ ID NO：1的dep34基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。
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公开(公告)号：US07038034B2
公开(公告)日：2006-05-02
申请号：US09948777
申请日：2001-09-10
摘要： The invention provides nucleotide sequences from Coryneform bacteria coding for the dep33 efflux protein and a process for the fermentative preparation of amino acids using bacteria in which the dep33 efflux protein is attenuated.
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公开(公告)号：US20060134761A1
公开(公告)日：2006-06-22
申请号：US11020188
申请日：2004-12-27
摘要： The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity.
摘要翻译： 本发明涉及对应于luxR基因并编码LuxR转录激活剂的多核苷酸，产生L-氨基酸的方法，以及筛选编码具有LuxR转录激活活性的蛋白质的多核苷酸的方法。
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